Depressive symptoms in patients with epilepsy: Analysis of self-rating and physician′s assessment

Ogunrin, Olubunmi; Obiabo, Yahaya

doi:10.4103/0028-3886.68679

Cited by 29 publications

(42 citation statements)

References 33 publications

(60 reference statements)

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“…Among these subjects with depression the severity of depression was: Mild in 39.9%, moderate in 38.5%, and severe 21.6%. The observed prevalence of depression in this study is comparable to the findings from other studies in developed and developing countries, [12,14,15,23] and four times higher as compared to a study in Canada. [13] This wide variation could be related to: Socio-demographic difference in the study setting, hospital-based vs. community-based.…”

Section: Discussionsupporting

confidence: 93%

“…[15] Other assumptions made during the sample size calculation were 5% margin of error (d) and level of 95% confidence interval (CI). Based on these assumptions, the sample size was calculated with a correction formula and 5% non-response rate providing the desired sample size of 300 PWE.…”

Section: Methodsmentioning

confidence: 99%

“…[24] Study done in Greece also showed seizure frequency and type of epileptic syndrome were associated with depression among PWE. [25] In a Nigerian study, seizure control appeared to be the most predictive factor of depression, [15] and in the study in Benin and Togo, depression was significantly associated with seizure frequency. [26] A study conducted in the US showed that higher levels of stigma correlated with higher level of depressive symptoms; furthermore, low social support and low level of patient satisfaction were significantly associated with depression among PWE.…”

Section: Introductionmentioning

confidence: 96%

“…[14] In Nigeria, study showed that the prevalence of depression among PWE was 42% and 45% using the Hamilton Rating Scale for Depression (HRSD) and the Beck Depression Inventory (BDI) measuring scales, respectively. [15] There is a general agreement that patients with epilepsy have a four-to five-fold higher risk of depression and up to a five-fold higher incidence of suicide than the general population. [16,17] Depression among PWE is associated with female gender, younger age, unemployment, lower income, unmarried status, lower levels of education, and antiepileptic medications (AEDs).…”

Section: Introductionmentioning

confidence: 99%

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Co-morbidity of depression and epilepsy in Jimma University specialized hospital, Southwest Ethiopia

et al. 2014

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Co-morbidity of depression and epilepsy in Jimma University specialized hospital, Southwest Ethiopia

et al. 2014

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“…[6][7][8] Some of the antiepileptic drugs (AEDs) may cause depression. 9 Other factors, such as seizure frequency, degree of seizure freedom and duration of epilepsy, have been shown to considerably contribute to the prevalence of depression among PWE [10]. Depression significantly affects the quality of life of PWE.…”

Section: Introductionmentioning

confidence: 99%

Screening symptoms of depression and suicidal ideation in people with epilepsy using the Beck depression inventory

Salgado

Nogueira

Yasuda

et al. 2012

J. epilepsy clin. neurophysiol.

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Objective: To measure the severity of symptoms of depression and suicidal ideation in people with epilepsy (PWE) before and after epilepsy surgery using the Beck Depression Inventory (BDI). We aimed to determine the factors associated to depression in PWE. Methods: PWE, regardless of epilepsy type, seizure type, duration or frequency of seizures, and AEDs were investigated. The sample (n=468) was divided into two groups: preoperatory (n=346) and pos-operatory (n=122). Results: Before epilepsy surgery female gender, unemployment and high seizure frequency were associated factors for the occurrence of symptoms of depression. After epilepsy surgery, the only factor associated to high level of depression symptoms was the lack of seizure remission. Suicidal ideation was associated to seizure frequency before and after epilepsy surgery. Conclusion: Our results confirm the generally held view that depression is common in PWE and provide further insight to the association of depression with certain socio-demographic and seizure-related factors before and after epilepsy surgery.Keywords: epilepsy, seizures, depression, suicidal ideation. RESUMO Rastreamento de sintomas de depressão e ideação suicida em pessoas com epilepsia usando o inventário de depressão de BeckObjetivo: Avaliar a gravidade dos sintomas de depressão e ideação suicida em pessoas com epilepsia (PCE), antes e após o tratamento cirúrgico utilizando o Inventário de Depressão de Beck (BDI). Nosso objetivo foi determinar os fatores associados à depressão em PCE. Métodos: PCE, independentemente do tipo de epilepsia, tipo de crises, duração ou frequência das crises, e DAEs, foram investigados. Os pacientes (n=468) foram divididos em dois grupos: pré-operatório (n=346) e de pós-operatório (n=122). Resultados: Antes do tratamento cirúrgico, o sexo feminino, o desemprego e a alta frequência de crises foram fatores associados à ocorrência de sintomas de depressão. Após a cirurgia de epilepsia, o único fator associado ao alto nível de sintomas de depressão foi a falta de remissão de crises. Ideação suicida foi associada à frequência de crises antes e após a cirurgia de epilepsia. Conclusão: Nossos resultados confirmam a opinião generalizada de que a depressão é comum nas PCE e proporcionam mais evidência para a associação de depressão com alguns fatores sócio demográficos e relacionados às crises antes e após o tratamento cirúrgico das epilepsias.Unitermos: epilepsia, crises epilépticas, depressão, ideação suicida.

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Prevalence and associated factors of psychiatric comorbidities in epilepsy in the Casablanca–Settat region of Morocco: A cross‐sectional study

Hajji,

Traore,

Hassoune

et al. 2024

Epilepsia Open

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ObjectiveTo determine the estimated prevalence of anxiety, depression, and anxiety–depression syndrome (ADS) and to identify the associated factors in Moroccan people with epilepsy (PWE).MethodA cross‐sectional study was conducted among adult PWE (June 2021–December 2022) in the Casablanca–Settat region. PWE were interviewed by completing a questionnaire collecting sociodemographic and clinical data. Anxiety and depression were assessed by the Hospital Anxiety and Depression Scale (HADS). Out of 21 points, a score ≥8 is in favor of considerable anxiety/depression symptoms and a sum of the two scores ≥15 indicates the presence of ADS. Data were analyzed using Statistical Package for Social Sciences (SPSS) 21.0. p‐values ≤0.05 were considered statistically significant and logistic regression was performed to determine the associated factors.ResultsAmong 294 PWE, the median age was 39 years (interquartile range [IQR]: 25.75–54.00). The median anxiety, depression, and ADS scores were 8 (IQR: 5.00–10.00), 7 (IQR: 4.00–10.00), and 15 (IQR: 10.00–20.00), respectively. Anxiety, depression, and ADS were revealed in 51.4%, 44.9%, and 51.0% of PWE, respectively. Depression was the only predictor for anxiety (aOR = 24.20; 95%CI: 12.45–47.01). Antiseizure polytherapy (aOR = 3.35; 95%CI: 1.72–6.54) and anxiety (aOR = 24.04; 95%CI: 12.12–47.67) were the factors associated with depression. The risk of ADS was increased by female gender (aOR = 2.83; 95%CI: 1.68–4.78), antiseizure polytherapy (aOR = 2.75; 95%CI: 1.62–4.65), structural epilepsy (aOR = 1.73; 95%CI: 1.01–2.94), and the presence of concomitant conditions with epilepsy (aOR = 1.96; 95%CI: 1.16–3.31).SignificanceOur study reports high psychiatric comorbidity prevalence in epilepsy, which supports the bidirectional link hypothesis. Associated factors found are important in the prognosis and prevention.Plain Language SummaryThe neural mechanisms underlying epilepsy tend to expose PWE to psychiatric disorders. Our study aims to quantify the rate of psychiatric comorbidities and their predictive factors in Moroccan PWE. The estimated prevalences of significant symptoms of anxiety, depression, and ADS were 51.4%, 44.9%, and 51.0%, respectively. Depression was the predictor of anxiety. Antiseizure polymedication and anxiety were the associated factors with depression. The risk of SAD was increased by female gender, antiseizure polymedication, structural epilepsy, and concomitant diseases with epilepsy. Our results are important for considering the psychiatric aspect of PWE and improving their care and quality of life.

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Depressive symptoms in patients with epilepsy: Analysis of self-rating and physician′s assessment

Abstract: Depressive symptoms are common in epilepsy. Early detection and prompt management are recommended. Good seizure control with an appropriate antiepileptic drug, among other interventional measures, may contribute to the prevention of depression in epilepsy.

Cited by 29 publications

References 33 publications

Co-morbidity of depression and epilepsy in Jimma University specialized hospital, Southwest Ethiopia

Co-morbidity of depression and epilepsy in Jimma University specialized hospital, Southwest Ethiopia

Screening symptoms of depression and suicidal ideation in people with epilepsy using the Beck depression inventory

Prevalence and associated factors of psychiatric comorbidities in epilepsy in the Casablanca–Settat region of Morocco: A cross‐sectional study

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