Depressive Symptoms Are Associated with Cognitive Function in the Elderly with Type 2 Diabetes

Guerrero‐Berroa, Elizabeth; Ravona‐Springer, Ramit; Schmeidler, James; Heymann, Anthony; Soleimani, Laili; Sano, Mary; LeRoith, Derek; Preiss, Rachel; Zukran, Ruth; Silverman, Jeremy M.; Beeri, Michal Schnaider

doi:10.3233/jad-170778

Cited by 14 publications

(19 citation statements)

References 56 publications

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“…In addition, scholars suggest that diabetes‐specific emotional distress will affect patients’ moods, because the greater the emotional distress, the more the depressive symptoms that will arise (Koekkoek et al., 2015), and depressive symptoms have complex connections with cognitive fields, such as executive function, language and overall cognition (Birch et al., 2016; Guerrero‐Berroa et al., 2018; Vance et al., 2016).…”

Section: Discussionmentioning

confidence: 99%

Life satisfaction and emotional distress in people living with type 2 diabetes mellitus: The mediating effect of cognitive function

Lee

Hsieh

Lin

2021

Journal of Clinical Nursing

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Aims and objectives To explore the relationships among emotional distress, cognitive function and life satisfaction in people living with type 2 diabetes mellitus (T2DM), and to verify the mediating role of cognitive function. Background People with T2DM face cognitive decline caused by age and disease complications. Emotional distress will reduce their life satisfaction, and cognitive function will also affect the life satisfaction, but whether cognitive function mediates the effect of emotional distress on life satisfaction has not been verified. Design A cross‐sectional study. Methods A total of 200 people living with T2DM in the community by convenience sampling were enrolled from November–December 2018. Data collection involved a demographic and disease characteristic questionnaire, Problem Areas in Diabetes Scale, Subjective and Objective Cognitive Function Evaluation and Life Satisfaction Questionnaire. Data analysis included descriptive statistics and structural equation modelling. This report followed the STROBE guideline. Results The emotional distress and subjective memory complaints of cognitive function had a significant positive correlation, while both emotional distress and cognitive function showed significant negative correlations with life satisfaction. In addition, cognitive function completely mediated the relationship between emotional distress and life satisfaction. Conclusion The cognitive function played a mediating role in life satisfaction and explains how emotional distress affects life satisfaction of people with T2DM. Therefore, it is suggested that diabetes nurses should early identify the decline of cognitive function, and to intervene at an early stage. Relevance to clinical practice This study provides opinions on the mediating factors of cognitive function. Coping strategies and supporting resources to help the T2DM people to improve their life satisfaction are suggested.

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Section: Discussionmentioning

confidence: 99%

Life satisfaction and emotional distress in people living with type 2 diabetes mellitus: The mediating effect of cognitive function

Lee

Hsieh

Lin

2021

Journal of Clinical Nursing

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“…In this case, the study which provided the longest follow-up was selected. In total, 19 articles were included in this systematic review [12][13][14][15][16][17][18][32][33][34][35][36][37][38][39][40][41], of which 10 were eligible for meta-analyses [15][16][17][18]32,34,36,37]. Other results were reported qualitatively.…”

Section: Study Selectionmentioning

confidence: 99%

“…Regarding cognition, eight cross-sectional studies [32][33][34][35][36][37][38]42], two prospective cohort studies [12,14] and one retrospective cohort study [13] were included (Table 1). The research area was distributed among the United States [13,14,33,34,37], United Kingdom [12], Israel [32], Singapore [35], China [38,42] and Canada [14]. Four studies assessed both types of DM [13,35,37,38], the remaining six studies only assessed type 2 DM [12,14,[32][33][34]36,42].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The research area was distributed among the United States [13,14,33,34,37], United Kingdom [12], Israel [32], Singapore [35], China [38,42] and Canada [14]. Four studies assessed both types of DM [13,35,37,38], the remaining six studies only assessed type 2 DM [12,14,[32][33][34]36,42]. Studies provided data on executive function [12,14,[32][33][34]36,37], complex attention [14,32,34,36,42], language [32,34,37], memory [12,14,32,34,36,37,42] and overall cognition [13,32,[34][35][36]…”

Section: Study Characteristicsmentioning

confidence: 99%

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Associations between depression and cognition, mild cognitive impairment and dementia in persons with diabetes mellitus: A systematic review and meta-analysis

Chow¹,

Verdonschot²,

McEvoy

et al. 2022

Diabetes Research and Clinical Practice

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This systematic review aimed to examine whether persons with diabetes and depression had poorer cognition and higher dementia risk than persons with diabetes only. Moreover, the impact of timing, frequency of depressive episodes throughout life, and antidepressant treatment were examined. Methods: PubMed, Embase and PsycINFO were searched to obtain observational studies between August 2015 and June 2021 that examined the association between depression and cognition, mild cognitive impairment or dementia in people with diabetes. Studies published before August 2015 were retrieved from a previous systematic review. Findings were pooled using meta-analyses. Results: 10 out of 19 included articles were appropriate for the meta-analyses. Persons with diabetes and depression experienced greater declines in executive function (SMD = − 0.39 (− 0.69, − 0.08)), language (SMD = − 0.80 (− 1.52, − 0.09)), memory (SMD = − 0.63 (− 1.12, − 0.14)) and overall cognition (SMD = − 0.77 (− 1.33, − 0.20)), and greater dementia risk (HR = 1.82 (1.79, 1.85)) than persons with diabetes only. No significant differences were observed for complex attention. No studies examined the role of timing and frequency of depressive episodes and antidepressant treatment. Conclusion:In persons with diabetes, depression is associated with worse cognition and higher dementia risk. The potential mitigating effect of antidepressant treatment remains unclear.

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“…Depressed people with diabetes perform significantly worse on EF tasks. However, this correlation was not significant in a subsample of 715 participants taking antidepressants ( Guerrero-Berroa et al, 2018 ), suggesting that depression-mediated impairment in EF among patients with diabetes can be alleviated with antidepressant treatment.…”

Section: Factors Involved In Diabetes-related Ef Deficitsmentioning

confidence: 94%

Executive Function and Diabetes: A Clinical Neuropsychology Perspective

et al. 2020

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Objective: Diabetes is a global public health concern. Management of diabetes depends on successful implementation of strategies to alleviate decline in executive functions (EFs), a characteristic of diabetes progression. In this review, we describe recent research on the relationship between diabetes and EF, summarize the existing evidence, and put forward future research directions and applications. Methods: Herein, we provide an overview of recent studies, to elucidate the relationship between DM and EF. We identified new screening objectives, management tools, and intervention targets for diabetes management. We also discuss the implications for clinical practice. Results: In both types 1 and 2 diabetes mellitus (DM), hyperglycemia substantially impairs EF in people of all age groups and ethnicities. Hypoglycemia can similarly impair EF. Interestingly, a decline in EF contributes to DM progression. Glucose dysregulation and EF decline exacerbate each other in a vicious cycle: poor blood glucose control, impaired EF, diabetes management task failure, then back to poor blood glucose control. Many pathophysiological indexes (e.g., obesity, metabolic index, inflammatory and immune factors), neuropsychological indexes (e.g., compliance, eating habits, physical exercise, sleep, and depression), and genetic factors are changed by this pathological interaction between DM and EF. These changes can provide insight into the pathophysiological mechanisms of diabetes-related EF decline. Conclusion: Further studies, including large-scale prospective and randomized controlled trials, are needed to elucidate the mechanism of the interaction between diabetes and EF and to develop novel strategies for breaking this cycle.

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Depressive Symptoms Are Associated with Cognitive Function in the Elderly with Type 2 Diabetes

Cited by 14 publications

References 56 publications

Life satisfaction and emotional distress in people living with type 2 diabetes mellitus: The mediating effect of cognitive function

Life satisfaction and emotional distress in people living with type 2 diabetes mellitus: The mediating effect of cognitive function

Associations between depression and cognition, mild cognitive impairment and dementia in persons with diabetes mellitus: A systematic review and meta-analysis

Executive Function and Diabetes: A Clinical Neuropsychology Perspective

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