Depressive symptoms are associated with oxidative stress in middle-aged women: a cross-sectional study

Hirose, Asuka; Terauchi, Masakazu; Akiyoshi, Mihoko; Owa, Yoko; Kato, Kiyoko; Kubota, Toshiro

doi:10.1186/s13030-016-0066-4

Cited by 34 publications

(21 citation statements)

References 43 publications

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“… 45 While some studies have reported increased 8-OHdG levels in depression, 1 study reported lower levels. 25 , 26 This discrepancy may have resulted from differences in the biological specimens, laboratory techniques, or the time of assessment used in the studies. 27 …”

Section: Discussionmentioning

confidence: 99%

High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors

Liu¹,

Cai²,

He³

2018

NDT

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PurposeAlthough previous studies have investigated oxidative stress biomarkers in association with depression in non-stroke subjects, the association between oxidative deoxyribonucleic acid damage and post-stroke depression (PSD) remains unelucidated.Patients and methodsTwo hundred forty-one first-ever ischemic stroke patients were consecutively recruited within the first 24 h of stroke onset and were followed up at 1 month. Serum 8-hydroxy-2′-deoxyguanosine (8-OHdG) and catalase (CAT) levels were measured within 24 h of admission using a commercially available enzyme-linked immunosorbent assay. The 17-item Hamilton Depression Scale was used to evaluate depressive symptoms. Diagnosis of PSD was made in line with the Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria for depression.ResultsSerum levels of 8-OHdG (P<0.001) and CAT (P=0.025) increased in depressed patients at admission. A positive correlation was found between the 8-OHdG and CAT levels in both the total stroke patients (r=0.320, P<0.001) and the depressed patients (r=0.300, P=0.012). The 8-OHdG levels were positively correlated with the 17-item Hamilton Depression Scale scores (r=0.129, P=0.046) in depressed patients. Multivariate analyses found that 8-OHdG levels ≥200.0 ng/L were independently associated with PSD (odds ratio, 7.477; 95% CI, 3.342–16.289, P<0.001) after adjusting for possible relevant confounders.ConclusionHigher serum 8-OHdG levels at admission were found to be correlated with PSD 1 month after stroke.

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Section: Discussionmentioning

confidence: 99%

High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors

Liu¹,

Cai²,

He³

2018

NDT

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“…Increased oxidative stress has been associated with behavioral depression in humans (31–37) and animals (38–42). Further, oxidative stress mitigation reduces depression severity in humans (33,43–45) and in animal models (38–42,46,47).…”

Section: Introductionmentioning

confidence: 99%

Conditional Human Immunodeficiency Virus Transactivator of Transcription Protein Expression Induces Depression-like Effects and Oxidative Stress

McLaughlin

Paris

Mintzopoulos

et al. 2017

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Background The prevalence of major depression in those with HIV/AIDS is substantially higher than in the general population. Mechanisms underlying this comorbidity are poorly understood. HIV-transactivator of transcription (Tat) protein, produced and excreted by HIV, could be involved. We determined whether conditional Tat protein expression in mice is sufficient to induce depression-like behaviors and oxidative stress. Further, as oxidative stress is associated with depression, we determined whether decreasing or increasing oxidative stress by administering methylsulfonylmethane (MSM) or diethylmaleate (DEM), respectively, altered depression-like behavior. Methods GT-tg bigenic mice received intraperitoneal saline or doxycycline (Dox, 25–100 mg/kg/day) to induce Tat expression. G-tg mice, which do not express Tat protein, also received Dox. Depression-like behavior was assessed with the tail suspension test (TST) and the two-bottle saccharin/water consumption task. Reactive oxygen/nitrogen species (ROS/RNS) were assessed ex vivo. Medial frontal cortex (MFC) oxidative stress and temperature were measured in vivo with 9.4-Tesla proton magnetic resonance spectroscopy (MRS). Results Tat expression increased TST immobility time in an exposure-dependent manner and reduced saccharin consumption. MSM decreased immobility time while DEM increased it in saline-treated GT-tg mice. Tat and MSM behavioral effects persisted for 28 days. Tat and DEM increased while MSM decreased ROS/RNS levels. Tat expression increased MFC glutathione levels and temperature. Conclusions Tat expression induced rapid and enduring depression-like behaviors and oxidative stress. Increasing/decreasing oxidative stress increased/decreased, respectively, depression-like behavior. Thus, Tat produced by HIV may contribute to the high depression prevalence among those with HIV. Further, mitigation of oxidative stress could reduce depression severity.

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“…Hypomagnesia associated with estrogen deficiency and periodontal inflammation could cause reactive oxidative stress (ROS) accumulation that manifests itself in depressive syndrome. 22 Hirose et al 9 argue that the depressive symptoms of middle-aged women is related to mood disorders and oxidative stress. In conclusion, the DPD and mineral level in GCF could be used as disorder indicators in menopausal women with periodontal diseases.…”

Section: Discussionmentioning

confidence: 99%

“…1 Thereafter, the main groups were divided into three sub-groups based on their menopausal phase: premenopausal (regular menstrual cycles in the past 3 months) or <50 years old (n=26), perimenopausal (experienced a menstrual period within the past 12 months but a missed period or irregular cycles during the past 3 months) or 50-55 years old (n=40), postmenopausal (no menstrual period during the previous 12 months) or >55 years old (n=18). 9,10 GCF was collected between 08.00 and 13.00 because levels of DPD peak during the morning hours. GCF was taken from the buccal site of the posterior tooth infected with gingivitis or periodontitis.…”

Section: Methodsmentioning

confidence: 99%

Deoxypyridinoline and mineral levels in gingival crevicular fluid as disorder indicators of menopausal women with periodontal disease

Dharmayanti

Kusumawardani

2018

Dent. J. (Maj. Ked. Gigi)

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Background: Menopause is a phase of a woman’s life marked by menstruation cycle cessation and an increased risk of periodontal disease. It can be caused by estrogen deficiency which alters the microenvironment in the sulcular gingival area and influences the composition and flow of gingival crevicular fluid (GCF). GCF has been widely studied as a non-invasive diagnostic and predictive tool for periodontal diseases. However, insufficient reports exist that explore its role as a predictive or diagnostic tool for bone loss detection in menopausal women. Purpose: This study aimed was to investigate deoxypyridinoline (DPD) and mineral levels that could be utilized as disorder indicators in menopausal women with periodontal disease. Methods: This study represents a form of analytical observation. Eighty-four patients of the Dental Hospital, University of Jember who fulfilled certain criteria were recruited. The subjects were divided into two main groups based on the presence of periodontal disease, (gingivitis=26; periodontitis=58) which were subsequently divided into three sub-groups based on their menopausal phase (pre-menopausal=26; perimenopausal=40; post-menopausal=18). GCF was collected using paper points from the buccal site of a posterior maxillary tooth with each subject having their GCF taken on only one occasion. DPD analysis was conducted by means of an ELISA test. The analysis of calcium, magnesium and sodium incorporated the use of an Atomic Absorption Spectroscope (AAS), while that of phosphor was by means of a spectrophotometer. Statistical analyses were performed using a comparison and correlation test (p<0.05). Results: There were significant differences in DPD and the mineral level of GCF in menopausal women with periodontal diseases (p<0.05). DPD and mineral levels showed significant correlation to those of menopausal women with periodontal diseases and a pH of GCF. Conclusion: DPD and mineral level in GCF could be used as disorder indicators in menopausal women with periodontal diseases.

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Depressive symptoms are associated with oxidative stress in middle-aged women: a cross-sectional study

Cited by 34 publications

References 43 publications

High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors

High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors

Conditional Human Immunodeficiency Virus Transactivator of Transcription Protein Expression Induces Depression-like Effects and Oxidative Stress

Deoxypyridinoline and mineral levels in gingival crevicular fluid as disorder indicators of menopausal women with periodontal disease

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