Depressive Symptoms, Antidepressant Medication Use, and Inflammatory Markers in the Diabetes Prevention Program

Groot, Mary de; Marrero, David G.; Mele, Lisa; Doyle, Todd; Schwartz, Frank; Mather, Kieren J.; Goldberg, Ronald; Price, David; Ma, Yong; Knowler, William C.

doi:10.1097/psy.0000000000000535

Cited by 9 publications

(3 citation statements)

References 40 publications

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“…Furthermore, we recruited drug-naïve MDD patients as serum levels of IL-6 and CRP can be influenced by antidepressant medications. Also, baseline CRP levels are affected by antidepressant therapy in MDD patients [ 26 ]. Another study found that serum IL-6 level decreased via the effects of paroxetine in patients with psychological symptoms [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Interleukin-6 and C-reactive Protein Levels in Drug-naïve Major Depressive Disorder Patients

Nishuty

Khandoker

Karmoker

et al. 2019

Cureus

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BackgroundMajor depressive disorder (MDD) is a disabling health problem with a very high global prevalence and burden. Alteration of inflammatory markers in depression is of growing interest to many psychiatry researchers. This study aimed to examine the serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) in MDD patients to find out their association with depression.Materials and methodsThe present study recruited 88 MDD patients and 86 control subjects matched by age, gender, and body mass index (BMI). The Hamilton depression rating scale (Ham-D) was used on all patients to measure their severity of depression. Serum levels of IL-6 and CRP were analyzed by commercially available enzyme-linked immunosorbent assay (ELISA) kits (Abcam, Cambridge, MA, USA).ResultsThe mean values of serum levels of IL-6 and CRP were 2.94 ± 0.12 pg/mL and 0.99 ± 0.02 mg/L for the patient group and 2.42 ± 0.21 pg/mL and 1.09 ± 0.06 mg/L for the control group, respectively. We found significantly elevated concentrations of serum IL-6 in MDD patients compared with control subjects (p < 0.001). However, the alteration of serum CRP levels was not significant between the groups (p = 0.126). Ham-D scores of patients were positively correlated with serum IL-6 (r = 0.552; p = 0.004) and CRP (r = 0.621; p < 0.001) levels. Moreover, serum IL-6 and CRP levels were observed to be positively correlated (r = 0.452; p = 0.043) with each other in depression.ConclusionsThe present study suggests that increased serum IL-6 level might be a contributing factor to the pathogenesis of depression.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Serum Interleukin-6 and C-reactive Protein Levels in Drug-naïve Major Depressive Disorder Patients

Nishuty

Khandoker

Karmoker

et al. 2019

Cureus

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“…The study [7] addresses the symptoms of diabetes. It also analyzes the use of antidepressants in the prevention of diabetes.…”

Section: Brief Review Of Recent Researchmentioning

confidence: 99%

A Study of Correlation Ratios for Low- and High-Density Lipoprotein in Comparison with Antioxidant Vitamins A, E, C at Different Levels of Glycosylated Hemoglobin among Type 2 Diabetes Patients

Altoum¹

2020

IJETER

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Diabetes is one of the chronic diseases in which the number of patients increases every year. Moreover, diabetes mellitus is a risk factor for the risk for the development of other diseases. Therefore, the number of studies that address various aspects of the diagnosis and control of the processes of diabetes is increasing. Among such studies, an important place is taken by the analysis of the relationship between low and high density lipoprotein and antioxidant vitamins A, E, C. Such an analysis can be done using various analytical methods. This expands medical diagnostics and treatment options for diseases. The study was based on a sample of 300 patients with type 2 diabetes. For analysis, we used: correlation analysis and the wavelet coherence method. The values of wavelet coherence between low and high density lipoprotein and antioxidant vitamins A, E, C for different levels of glycosylated hemoglobin were obtained. This provides an explanation of the differences in the relationship between low and high density lipoprotein and antioxidant vitamins. Also a more consistent dynamics is observed between antioxidant vitamins A, E, C and HDL, taking into account changes in glycosylated hemoglobin levels. This is a key factor in understanding the greater correlations between antioxidant vitamins A, E, C, and HDL.

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“…Because antidepressants are used for treatment of a variety of illnesses other than depression, including COVID-19 (6), the safety of antidepressant use is of considerable public interest. Antidepressant medication has been linked to several mild and more severe adverse effects, including increased mortality (7,8), type 2 diabetes and serum inflammatory markers (9), and CVD outcomes like major adverse cardiac events (10), heart rhythm disorders (11) changes in the right ventricular volume (12), risk of abnormal bleeding (13,14), and hemorrhagic stroke (15). There are also beneficial adverse effects of antidepressants, like the inhibition of platelet aggregation (14) and anti-inflammatory effects (16).…”

Section: Introductionmentioning

confidence: 99%

Antidepressant Use and Risk of Myocardial Infarction: A Longitudinal Investigation of Sex-Specific Associations in the HUNT Study

2022

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Objective: Antidepressants are thought to affect the risk of cardiovascular disease, although the nature of the association is unclear. Men and women have unique cardiovascular risk factors, and sex differences in depression as well as the efficacy of antidepressants are important to consider. We examined whether antidepressant use was associated with risk of having a myocardial infarction (MI) and whether this association was sex-specific. Methods: Data from The Trøndelag Health Study were used, gathered from a population in Norway (N = 31,765), collected from 1995 to 2008. These data were combined with the Norwegian Cause of Death Registry and the Norwegian Prescription Database. We performed logistic regression models to examine the association of antidepressant use on risk of having a fatal or nonfatal MI, adjusting for depression, anxiety, diabetes, systolic blood pressure, cholesterol, waist-hip ratio, smoking, age, and sex. Results are presented as odds ratios (ORs) and 95% confidence intervals in parentheses. Results: The results indicated that antidepressant use was associated with a reduced risk of having MI at a later date (OR = 0.49 [0.38-0.64]). Although this association was somewhat stronger for women (OR = 0.46 [0.31-0.68]) compared with men (OR = 0.53 [0.37-0.75]), analysis did not identify a sex-specific association of antidepressant use on MI. Follow-up analyses on different subtypes of antidepressants showed that both selective serotonin reuptake inhibitor and tricyclic antidepressant were associated with a reduced risk of MI. Conclusions: In this population study, the use of antidepressants was associated with a reduced risk of MI. This association was stronger for women, although we detected no interaction between sex and antidepressant use in terms of reduced risk of MI. Although limitations apply regarding causality, especially concerning a dose-response relationship, the results suggest that antidepressant use might reduce the risk of MI among both men and women.

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Depressive Symptoms, Antidepressant Medication Use, and Inflammatory Markers in the Diabetes Prevention Program

Abstract: ADM was significantly associated with elevated CRP and incident T2DM. In the PLB group, ADM and CRP independently predicted onset of T2DM; however, CRP did not significantly mediate the effect of ADM.

Cited by 9 publications

References 40 publications

Evaluation of Serum Interleukin-6 and C-reactive Protein Levels in Drug-naïve Major Depressive Disorder Patients

Evaluation of Serum Interleukin-6 and C-reactive Protein Levels in Drug-naïve Major Depressive Disorder Patients

A Study of Correlation Ratios for Low- and High-Density Lipoprotein in Comparison with Antioxidant Vitamins A, E, C at Different Levels of Glycosylated Hemoglobin among Type 2 Diabetes Patients

Antidepressant Use and Risk of Myocardial Infarction: A Longitudinal Investigation of Sex-Specific Associations in the HUNT Study

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