Depressive-like behavioral alterations and c-fos expression in the dopaminergic brain regions in WAG/Rij rats with genetic absence epilepsy

Sarkisova, K. Yu.; Midzianovskaia, I.S; Куликов, М. А.

doi:10.1016/s0166-4328(03)00090-1

Cited by 95 publications

(79 citation statements)

References 44 publications

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“…Forced swim test (FST) is one of the most widely used protocols for studying both pharmacological and pathophysiological aspects of depression [21][22][23][24][25]. FST creates a situation of despair, and allows evaluation of the ability of the animal to adopt active strategies in inescapable stressful situation; failure to do so is indicative of a depression-like state [21,25] .…”

Section: Behavioral Testsmentioning

confidence: 99%

“…In rats, anhedonia can be assessed by the loss of taste preference; while normal animals prefer sweetened water over regular water, animals with depression do not exhibit such a preference [23,24,[28][29][30].…”

Section: Behavioral Testsmentioning

confidence: 99%

“…Taste preference was examined using both saccharin (calorie-free) and sucrose (caloriecontaining) consumption tests [23,29,31,32]. The animals had free access to a standard rodent diet.…”

Section: Behavioral Testsmentioning

confidence: 99%

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Kindling epileptogenesis in immature rats leads to persistent depressive behavior

Mazarati¹,

Shin²,

Auvin³

et al. 2007

Epilepsy & Behavior

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Depression is a frequent comorbidity in epilepsy patients. A variety of biological factors may underlie epilepsy-associated depression. We examined whether kindling-induced chronic increase in seizure susceptibility is accompanied by behavioral symptoms of depression. Three week-old Wistar rats underwent rapid kindling -84 initially subconvulsant electrical stimulations of ventral hippocampus delivered every five minutes -followed by depression-specific behavioral tests performed two and four weeks later. Kindled animals exhibited sustained increase in the immobility time in the forced swim test and the loss of taste preference towards calorie-free saccharin, as compared to controls. Initial loss of preference towards the intake of calorie-containing sucrose was followed by the increased consumption at four weeks. At both time points, animals exhibited enhanced seizure susceptibility upon test stimulations of the hippocampus. We conclude that neuronal plastic changes associated with kindling state are accompanied by the development of depressive behavior.

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Section: Behavioral Testsmentioning

confidence: 99%

Section: Behavioral Testsmentioning

confidence: 99%

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Kindling epileptogenesis in immature rats leads to persistent depressive behavior

Mazarati¹,

Shin²,

Auvin³

et al. 2007

Epilepsy & Behavior

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“…Genetic epilepsy-prone rats showed reduced hippocampal 5-HT 1A receptor density. These rats showed depressive-like behaviors (as measured on the forced swimming test) that responded to antidepressants, and abnormal stress responses (8,9,46). Serotonininduced anticonvulsive effects were mediated specifically by hippocampal 5-HT 1A receptors (32).…”

Section: Introductionmentioning

confidence: 99%

5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

Hasler

Bonwetsch

Giovacchini

et al. 2007

Biological Psychiatry

128

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Background-Major depressive disorder (MDD) is the most common comorbid psychiatric condition associated with temporal lobe epilepsy (TLE). Preclinical and clinical studies suggest that 5-HT 1A receptors play a role in the pathophysiology of both TLE and MDD. There is preliminary evidence for an association between decreased 5-HT 1A receptor binding in limbic brain areas and affective symptoms in TLE patients. The objective of this study was to compare 5-HT 1A receptor binding between TLE patients with and without MDD. For the first time, 5-HT 1A receptor binding was measured in a sample large enough to permit sensitive comparisons between TLE patients with and without comorbid MDD diagnosed by clinical and structured psychiatric interviews.

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“…During active and passive avoidance a deficit of reinforcement in WAG/Rij rats has been revealed (Getsova et al, 2003;Getsova et al, 2004) which was eliminated by administration of the DA precursor, or a low doze of disulfiram, inhibitor of dopamine-β-hydroxylase, by increase of DA concentration in brain. Besides, there was shown that WAG/Rij rats have a higher level of depression than control Wistar rats without of absence epilepsy (Sarkisova et al, 2003;Sarkisova & Kulikov 2006). Depression of WAG/Rij rats has a DA-ergic nature (Sarkisova et al, 2008).…”

Section: Da Activity In Wag/rij Ratsmentioning

confidence: 97%

Two Types of Epilepsy Models and Processes of Cognition: Pentylenetetrazole Kindling and Absence Epilepsy of WAG/Rij Rats Strain

Bazyan¹

2011

Underlying Mechanisms of Epilepsy

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Depressive-like behavioral alterations and c-fos expression in the dopaminergic brain regions in WAG/Rij rats with genetic absence epilepsy

Cited by 95 publications

References 44 publications

Kindling epileptogenesis in immature rats leads to persistent depressive behavior

Kindling epileptogenesis in immature rats leads to persistent depressive behavior

5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

Two Types of Epilepsy Models and Processes of Cognition: Pentylenetetrazole Kindling and Absence Epilepsy of WAG/Rij Rats Strain

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