5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

Hasler, Gregor; Bonwetsch, Robert; Giovacchini, Giampiero; Toczek, Maria T.; Bagić, Anto; Luckenbaugh, David A.; Drevets, Wayne C.; Theodore, William H.

doi:10.1016/j.biopsych.2007.02.015

Cited by 128 publications

(64 citation statements)

References 50 publications

(62 reference statements)

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“…In particular, Gilliam et al (54) reported greater resting temporal lobe hypometabolism in patients who reported higher levels of depression, and Victoroff et al (60) found an association between the severity of left temporal lobe hypometabolism and the frequency of major depressive episodes in patients with epilepsy. There is also recent evidence demonstrating an association between reduced 5-HT(1A) receptor binding in the hippocampus and higher levels of self-reported depression in patients with TLE (61,62). In another study, a trend was noted for increased left amygdalar, but not hippocampal, metabolism to correlate with increased depression in TLE (21).…”

Section: Petmentioning

confidence: 94%

The use of neuroimaging to study behavior in patients with epilepsy

McDonald¹

2008

Epilepsy & Behavior

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Structural and functional neuroimaging continue to play an increasing role in the presurgical evaluation of patients with epilepsy. In addition to their value for localizing the epileptogenic zone and eloquent cortex, neuroimaging is contributing to our understanding of mood comorbidity in epilepsy. Although the vast majority of research has focused on patients with temporal lobe epilepsy (TLE), neuroimaging studies of patients with frontal lobe epilepsy (FLE) and primary generalized epilepsy are increasing in number. In this review, structural and functional imaging modalities that have received considerable research attention in recent years are reviewed, along with an assessment of their strengths and limitations for understanding behavior in epilepsy. In addition, advances in multimodal imaging are discussed along with their potential application to the presurgical evaluation of patients with seizure disorders.

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Section: Petmentioning

confidence: 94%

The use of neuroimaging to study behavior in patients with epilepsy

McDonald¹

2008

Epilepsy & Behavior

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“…32,33 The ROI was an ellipsoid that fit well within the anterior hippocampus and spanned five 2-mm axial slices. For each subject, the ROI in each slice was repositioned such that only hippocampus was included within the ROI.…”

Section: Mri Acquisition and Preprocessingmentioning

confidence: 99%

The Relationship between Glucose Metabolism, Resting-State fMRI BOLD Signal, and GABA_A-Binding Potential: A Preliminary Study in Healthy Subjects and Those with Temporal Lobe Epilepsy

Nugent

Martinez

D'Alfonso

et al. 2015

J Cereb Blood Flow Metab

113

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Glucose metabolism has been associated with magnitude of blood oxygen level-dependent (BOLD) signal and connectivity across subjects within the default mode and dorsal attention networks. Similar correlations within subjects across the entire brain remain unexplored. [18 F]-fluorodeoxyglucose positron emission tomography ([ 18 F]-FDG PET), [ 11 C]-flumazenil PET, and resting-state functional magnetic resonance imaging (fMRI) scans were acquired in eight healthy individuals and nine with temporal lobe epilepsy (TLE). Regional metabolic rate of glucose (rMRGlu) was correlated with amplitude of low frequency fluctuations (ALFFs) in the fMRI signal, global fMRI connectivity (GC), regional homogeneity (ReHo), and gamma-aminobutyric acid A-binding potential (GABA A BP ND ) across the brain. Partial correlations for ALFFs, GC, and ReHo with GABA A BP ND were calculated, controlling for rMRGlu. In healthy subjects, significant positive correlations were observed across the brain between rMRGlu and ALFF, ReHo and GABA A BP ND , and between ALFFs and GABA A BP ND , controlling for rMRGlu. Brain-wide correlations between rMRGlu and ALFFs were significantly lower in TLE patients, and correlations between rMRGlu and GC were significantly greater in TLE than healthy subjects. These results indicate that the glutamatergic and GABAergic systems are coupled across the healthy human brain, and that ALFF is related to glutamate use throughout the healthy human brain. TLE may be a disorder of altered long-range connectivity in association with glutamate function.

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“…These studies revealed similar functional abnormalities in primary MDD and temporal lobe epilepsy (TLE) (without depression), which consisted of decreased 5-HT1A receptor binding in the hippocampus, amygdala, cingulate gyrus, insula, and raphe nucleus [13][14][15][16]. In one study of patients with TLE and normal hippocampus volume, the decrease in 5-HT 1A binding was restricted to the temporal pole [17], and was more pronounced in the seizure-onset zone and in regions where the discharge propagated than in regions where only interictal paroxysms or no epileptic activity was recorded [18].…”

Section: Serotoninmentioning

confidence: 82%

Biomarkers of Epileptogenesis: Psychiatric Comorbidities (?)

Kanner

Mazarati

Koepp³

2014

Neurotherapeutics

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The last decade has witnessed a significant shift on our understanding of the relationship between psychiatric disorders and epilepsy. While traditionally psychiatric disorders were considered as a complication of the underlying seizure disorder, new epidemiologic data, supported by clinical and experimental research, have suggested the existence of a bidirectional relation between the two types of conditions: not only are patients with epilepsy at greater risk of experiencing a psychiatric disorder, but patients with primary psychiatric disorders are at greater risk of developing epilepsy. Do these data suggest that some of the pathogenic mechanisms operant in psychiatric comorbidities play a role in epileptogenesis? The aim of this article is to review the epidemiologic data that demonstrate that primary psychiatric disorders are more frequent in people who develop epilepsy, before the onset of the seizure disorder than among controls. The next question looks at the available data of pathogenic mechanisms of primary mood disorders and their potential for facilitating the development and/or exacerbation in the severity of epileptic seizures. Finally, we review data derived from experimental studies in animal models of depression and epilepsy that support a potential role of pathogenic mechanisms of mood disorders in the development of epileptic seizures and epileptogenesis. The data presented in this article do not yet establish conclusive evidence of a pathogenic role of psychiatric comorbidities in epileptogenesis, but raise important research questions that need to be investigated in experimental, clinical, and population-based epidemiologic research studies.

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5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

Cited by 128 publications

References 50 publications

The use of neuroimaging to study behavior in patients with epilepsy

The use of neuroimaging to study behavior in patients with epilepsy

The Relationship between Glucose Metabolism, Resting-State fMRI BOLD Signal, and GABA_A-Binding Potential: A Preliminary Study in Healthy Subjects and Those with Temporal Lobe Epilepsy

Biomarkers of Epileptogenesis: Psychiatric Comorbidities (?)

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5-HT1A Receptor Binding in Temporal Lobe Epilepsy Patients With and Without Major Depression

Cited by 128 publications

References 50 publications

The use of neuroimaging to study behavior in patients with epilepsy

The use of neuroimaging to study behavior in patients with epilepsy

The Relationship between Glucose Metabolism, Resting-State fMRI BOLD Signal, and GABAA-Binding Potential: A Preliminary Study in Healthy Subjects and Those with Temporal Lobe Epilepsy

Biomarkers of Epileptogenesis: Psychiatric Comorbidities (?)

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The Relationship between Glucose Metabolism, Resting-State fMRI BOLD Signal, and GABA_A-Binding Potential: A Preliminary Study in Healthy Subjects and Those with Temporal Lobe Epilepsy