Depressive disorders in Chinese patients with Alzheimer's disease

Liu, C. Y.; Fuh, Jong Ling; Teng, Evelyn L.; Wang, P. N.; Yang, Yuchen; Liu, H. C.

doi:10.1111/j.1600-0447.1999.tb10896.x

Cited by 16 publications

(18 citation statements)

References 30 publications

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“…Another community study in Asia [24] found that there was a low risk of depression in women and that it was not severe when present. No other epidemiological studies have analysed the relationship between demographic variables and the prevalence of neuropsychiatric symptoms.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Neuropsychiatric Symptoms in Elderly Patients with Dementia in Mungialde County (Basque Country, Spain)

Martínez

Flores

Heras³

et al. 2007

Dement Geriatr Cogn Disord

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Background: Determination of the prevalence of neuropsychiatric symptoms in elderly patients with dementia inMungialde. Methods: 108 subjects with dementia, who participated in a door-to-door epidemiological study, were included. The 12-item Spanish version of the Neuropsychiatric Inventory was used to evaluate these symptoms. Results: The prevalence of at least 1 neuropsychiatric symptom was found to be 76.90% for all dementia types, 73.50% in patients with Alzheimer’s disease (AD), 80% for the Parkinson-Lewy body dementia complex (PLBD), 78.60% for vascular dementia (VD) and 100% for frontotemporal dementia (FTD). Apathy was found to be the most prevalent symptom for all dementia types and in patients with AD (53.70 and 54.30%, respectively). The next most prevalent symptoms were anxiety, depression and sleep disturbances (35.20, 32.40 and 30.60%) for all dementia types, and anxiety and depression (32.10 and 30.90%) in patients with AD. The most prevalent symptoms in patients with PLBD were apathy, appetite changes, sleep disturbances and agitation (50% each); in patients with VD they were apathy, depression and anxiety (42.90% each), and in patients with FTD they were apathy, anxiety and aberrant motor activity (100% each). Conclusions: Neuropsychiatric symptoms were found to be prevalent in patients with dementia, irrespective of dementia type.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Neuropsychiatric Symptoms in Elderly Patients with Dementia in Mungialde County (Basque Country, Spain)

Martínez

Flores

Heras³

et al. 2007

Dement Geriatr Cogn Disord

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“…One hundred and forty-one AD patients from our memory clinic were recruited for this study [1]. All patients met the criteria of the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) for probable AD [23].…”

Section: Methodsmentioning

confidence: 99%

“…With diverse inclusion criteria ranging from simply depressive symptoms to major depression, the prevalence reported in the literature has been anywhere from 0 to 87% [1][2][3]. A higher prevalence rate is obtained when depression is defined by scoring above a certain cutoff point on neuropsychological scales rather than according to the clinical diagnosis [1]. To explain the association between depression and AD, either a reactive phenomenon or a brain process of dementia itself has been proposed [4].…”

Section: Introductionmentioning

confidence: 99%

Selective Hypoperfusion of Anterior Cingulate Gyrus in Depressed AD Patients: A Brain SPECT Finding by Statistical Parametric Mapping

Liao

Liu

Lee

et al. 2003

Dement Geriatr Cogn Disord

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This study tests the hypothesis that depression in patients with Alzheimer’s disease (AD) is due to a specific pathogenesis rather than a reactive phenomenon. Forty-three AD patients received a psychiatrist’s interview, neuropsychological assessments, and a ^99mTc-hexamethyl propyleneamine oxime single photon emission computed tomography (HMPAO-SPECT). Analysis by statistical parametric mapping (SPM) showed that the depressed group had selective hypoperfusion in the bilateral anterior and posterior cingulate gyri and precuneus. Using the Hamilton Depression Rating Scale as a parameter, an inverse correlation was found between cerebral perfusion and the severity of depression. The right anterior cingulate gyrus demonstrated a most significant reduction in perfusion. These locations are akin to the imaging findings in patients with primary depression, indicating a specific pathogenesis for depression in AD.

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“…A wide range of prevalence figures for depression in AD have been reported with most ranging between 30 and 50% (Olin et al, 2002). The reported range is wider, 3.5-39.6%, in African and Cuban ethnic minorities and Chinese cultures (Liu et al, 1999;Harwood et al, 2000a,b). Our findings might reflect cultural differences in symptoms of AD although other factors such as carers and referral bias or simply lack adequate psychiatric services might have contributed.…”

Section: Discussionmentioning

confidence: 95%

The symptomatology of Alzheimer's disease: a cross-cultural study

Karim

Minhas

Bhattacharya

et al. 2010

Int. J. Geriat. Psychiatry

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The study has shown a number of possible cultural differences in affective symptoms, personality changes and every day activities. It highlights the need for developing mental health services for older people in Pakistan and making UK services more accessible for this growing community. Further research on service and care needs along with developing culturally sensitive instruments for assessing cognition, psychiatric symptoms, personality changes and daily activities is needed.

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Depressive disorders in Chinese patients with Alzheimer's disease

Abstract: The prevalence of depressive disorders among Chinese AD patients is in the middle of the range of western findings. The risk factor for depression is female gender.

Cited by 16 publications

References 30 publications

Prevalence of Neuropsychiatric Symptoms in Elderly Patients with Dementia in Mungialde County (Basque Country, Spain)

Prevalence of Neuropsychiatric Symptoms in Elderly Patients with Dementia in Mungialde County (Basque Country, Spain)

Selective Hypoperfusion of Anterior Cingulate Gyrus in Depressed AD Patients: A Brain SPECT Finding by Statistical Parametric Mapping

The symptomatology of Alzheimer's disease: a cross-cultural study

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