Prevalence of Neuropsychiatric Symptoms in Elderly Patients with Dementia in Mungialde County (Basque Country, Spain)

Martínez, Manuel Fernández; Flores, Jéssica Castro; Heras, Susana Pérez de las; Lekumberri, Aitxiber Mandaluniz; Menocal, María Gordejuela; Imirizaldu, Juan José Zarranz

doi:10.1159/000112215

Cited by 37 publications

(17 citation statements)

References 41 publications

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“…In fact, in our study, depression occupied the third position with a prevalence of 44%. These results are in accordance with those obtained in previous studies [28,36-38]. However, depression frequencies are variable [39,15].…”

Section: Discussionsupporting

confidence: 93%

“…The frequency of hallucinations in our study is around 30%,, a percentage somewhat higher than that reported with the NPI in both epidemiological [15,36] and clinical populations [18,19]. Although this figure only indicates the presence of hallucinations in the last year, it does raise the possibility that there may have been a number of patients with DLB in our study population, particularly since many DLB patients could meet DSM-IV criteria for AD.…”

Section: Discussioncontrasting

confidence: 66%

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Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment

2010

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BackgroundBehavioural and psychological symptoms of dementia (BPSD) are non-cognitive symptoms commonly associated to Alzheimer's disease (AD). The characterization of the clinical profile of AD patients might help to better understand disease evolution and to improve diagnosis and treatment. Thus, the aim of the present study is to describe the clinical profile of AD patients, and to correlate the presence of BPSD with the severity of the disease.MethodsA cross-sectional, observational and multicenter study was conducted at 115 centres in Spain. Patients suffering from AD with higher and lower BPSD scores (ADAS-Noncog score 26-50 and ≤25, respectively) were included. Demographic and clinical data were collected, and dementia severity was assessed by the Mini Mental State Examination (MMSE) [mild 27-21, moderate 20-11, severe ≤10]. The use of ADAS-Noncog in clinical practice was also explored.ResultsA total of 1014 patients (463 with higher and 551 with lower BPSD scores) were included (mean age 77 ± 7 years, 65% women). Almost all patients (90%) had BPSD at inclusion, 17% of which reported psychotic outbreaks. The most prevalent symptoms were lack of concentration (56%), tremors (56%), depression (44%), lack of cooperation (36%), and delusions (32%). Patients with higher BPSD scores showed a significantly higher prevalence of psychotic symptoms (delusions, hallucinations, and delirium) and tremors, while emotional symptoms (tearfulness and apathy) predominated in patients with lower BPSD scores. MMSE and ADAS-Noncog scores were negatively associated (p = 0.0284), suggesting a correlation between cognitive impairment and BPSD. Lack of concentration and appetite change significantly correlated with MMSE (p = 0.0472 and p = 0.0346, respectively). Rivastigmine and donepezil were the first choice therapies in mild to moderate dementia. ADAS-Noncog was generally considered better or similar to other scales (82%), and 68% of the investigators were willing to use it in the future.ConclusionsOur study shows that patients with AD have a high prevalence of noncognitive symptoms, and that cognitive impairment and BPSD are correlated. Therefore, ADAS-Noncog is a useful evaluation tool.

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 66%

Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment

2010

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“…A nationwide hospital‐based study in Korea showed that depression (50.6%) and apathy (49.6%) were the most common symptoms among mild‐to‐moderate AD patients . Psychological symptoms are occasionally affected by social or familiar environment, and BPSD vary by nation, culture, age, sex and duration of illness …”

Section: Discussionmentioning

confidence: 99%

Characteristic features of cognitive, affective and daily living functions of late‐elderly dementia

Hishikawa

Fukui

Sato

et al. 2015

Geriatrics Gerontology Int

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Aims:The world is rapidly aging, and is facing an increase of late-elderly dementia patients. It is important to investigate the characteristic features of late-elderly dementia in the super-aged country. Methods: We examined 1,554 patients with cognitive decline in our clinic, dividing into 3 subgroups according to the age; young-(≤64 years old [y.o.]), middle-(65-74 y.o.), and late-elderly (75 y.o.≤), and investigated the cognitive, affective, and activities of daily living functions (ADL), especially in late-elderly patients comparing with young-and middle-elderly patients. Results: Among 1,554 patients, Alzheimer's disease (AD) dominated 62%, and which was age-dependently increased up to 69% in late-elderly group. Total scores of 4 cognitive tests were significantly worse with aging with specific subscales of orientation, recall, visual retention, word fluency, etc. On the other hand, total scores of the affective tests showed only an increase in apathy scale in the late-elderly group. Each subgroup showed depressive/depression in 63.2-55.2 %, and apathy in 44.2-54.8%. Furthermore, instrumental ADL items significantly deteriorated in the late-elderly group, which statistically correlated with mini-mental state examination (MMSE) score. Conclusions: These results demonstrates that late-elderly group is characterized by significant cognitive declines, increasing apathy, more than half in depressive/depression and apathy, and instrumental ADL decrease. The cognitive decline may be related to such affective and ADL declines.

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“…Furthermore, symptoms of anxiety have been found to be a possible predictor of cognitive impairment in people over the age of 60 years [15]. Using various assessment scales, we know that anxiety and agitation is common [16] among patients with dementia. But as demented patients have difficulties in expressing their emotions, it is possible that agitation could be an expression of anxiety.…”

Section: Introductionmentioning

confidence: 99%

Symptoms of Anxiety in Older Adults with Depression, Dementia, or Psychosis: A Principal Component Analysis of the Geriatric Anxiety Inventory

Bendixen

Hartberg²,

Selbæk³

et al. 2016

Dement Geriatr Cogn Disord

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Aims: The primary aim of this study was to examine anxiety symptoms as measured by the Geriatric Anxiety Inventory (GAI) in older patients with depression, dementia, or psychotic disorders. The secondary aim was to conduct a principal component analysis (PCA) of the GAI and to examine whether its subscales differ between the 3 disorders. Methods: We included data from 428 patients who were admitted to a department of geriatric psychiatry and examined according to a standardized protocol. The GAI was used to measure current anxiety symptoms. Results: The GAI symptoms occurred more frequently in the group with depression than in the other 2 groups. The PCA of the GAI with oblimin rotation resulted in a 2-component solution, labelled as “worries” (explained variance 46.3%, Cronbach's α 0.92) and “physical symptoms” (explained variance 7.1%, Cronbach's α 0.85). Conclusion: The results indicate that in old age, anxiety is especially prevalent in depression. The 2-component solution indicates that the GAI measures 2 different aspects of anxiety with different symptomatology.

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Prevalence of Neuropsychiatric Symptoms in Elderly Patients with Dementia in Mungialde County (Basque Country, Spain)

Cited by 37 publications

References 41 publications

Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment

Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment

Characteristic features of cognitive, affective and daily living functions of late‐elderly dementia

Symptoms of Anxiety in Older Adults with Depression, Dementia, or Psychosis: A Principal Component Analysis of the Geriatric Anxiety Inventory

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