Depressive changes after fluphenazine treatment.

Segal, Marylin; Ropschitz, D. H.

doi:10.1136/bmj.4.5676.169-b

Cited by 14 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Researchers who investigate negative symptoms explicitly or implicitly consider them to be a distinct and specifically schizophrenic manifestation. At the operational level, however, both individual symptoms and the syndrome itself have been described in various other contexts (see table 1), including “postpsychotic depression” (McGlashan and Carpenter 1976 a , 1976 b ), postpsychotic regressive state (Kayton, Beck, and Koh 1976), akinetic depression (Van Putten and May 1978), revealed depression (Knights and Hirsch 1981; Hirsch 1982), institutionalization (Goffman 1961; Wing and Brown 1970), pharmacogenic depression (Johnson 1969; Marjot 1969; Segal and Ropschitz 1969; Ayd 1975; Ananth and Chadirian 1980), and nonspecific depressive syndromes occurring either as part of the schizophrenic disease process (whether primary or secondary) (Shanfield et al 1970; Planansky and Johnston 1978; Johnson 1981; Moller and von Zerssen 1982; Strian, Heger, and Klicpera 1982; Siris et al 1983; Hogarty and Munetz 1984) or indicating that the diagnosis of schizophrenia is incorrect (Sheldrick et al 1977; Gopelrud and Depue 1978, 1979; Pope and Lipinski 1978; Siris et al 1983; Strauss 1983. )…”

Section: Conceptual Ambiguity Of Negative Symptomsmentioning

confidence: 99%

"Negative Symptoms": Conceptual and Methodological Problems

Sommers¹

1985

Schizophrenia Bulletin

188

View full text Add to dashboard Cite

Research into the so-called negative symptoms of schizophrenia is plagued by often ignored problems in item identification, scale selection, quantification, clinical assessment process, and symptom (and, probably, causal) nonspecificity. Neither a negative symptom syndrome per se nor the recent rating scales designed to measure it have been validated, although some data useful in this regard have been presented for the scales. Since no criterion against which to validate these scales exists, construct validation is needed. The construct of negative symptoms, as defined by its hypothesized empirical relationships with other variables, and the procedures used to measure it must be validated simultaneously and gradually through a programmatic series of studies. In the meantime, research results pertaining to negative symptoms should be interpreted with considerable caution.

show abstract

Section: Conceptual Ambiguity Of Negative Symptomsmentioning

confidence: 99%

"Negative Symptoms": Conceptual and Methodological Problems

Sommers¹

1985

Schizophrenia Bulletin

188

View full text Add to dashboard Cite

show abstract

“…Therefore, depression and suicide appear to be part of the clinical picture and not complications. Segal and Ropschitz (11) reported that one of their patients committed suicide 3 days after her last injection of fluphenazine. In addition, they noted that a significant number of patients on oral medication also manifested depression.…”

Section: Phenothiazinesmentioning

confidence: 99%

Drug-Induced Mood Disorders

Ananth¹,

Ghadirian²

1980

Int Pharmacopsychiatry

View full text Add to dashboard Cite

Various drugs including antihypertensives, anxiolytics, antibiotics, antidepressants, corticosteroids, choline, indomethacin, levodopa, metronidazole, neuroleptics, oral contraceptives, sulphonamides and physostigmine have been reported to produce depression as a side effect. Clinically, these drug-induced depressions may go unnoticed and thus create therapeutic problems. Although causal relationship is difficult to establish, depression occurring during the course of drug treatment needs an evaluation of all the medications that the patient has been receiving. We believe that postpsychotic depressions include three types of depression: pendular depression — primarily disease related; chronic depression - primarily environment related, and amine-depletion depression - drug related. Thus, drug-induced depressions constitute a subgroup of postpsychotic depression. Clinically, it is essential to carefully monitor patients receiving drugs known to produce depression. Thus, prompt recognition of the drug-induced depressions may assist in initiating proper therapeutic measures.

show abstract

The Long-Acting Phenothiazines

Groves¹

1975

Arch Gen Psychiatry

View full text Add to dashboard Cite

Depressive changes after fluphenazine treatment.

Cited by 14 publications

References 0 publications

"Negative Symptoms": Conceptual and Methodological Problems

"Negative Symptoms": Conceptual and Methodological Problems

Drug-Induced Mood Disorders

The Long-Acting Phenothiazines

Contact Info

Product

Resources

About