The Long-Acting Phenothiazines

Chemotherapy With Neuroleptics

“…These pharmacokinetic findings have been confirmed by quite a few clinical, comparative studies, in which decanoate has proved to have longer depot effect and fewer side effects (291,292,293,295). As a consequence hereof it has in the USA been decided to market the decanoate preparation only.…”

Prospective, Open Study of Long-Acting Injected Risperidone versus Oral Antipsychotics in 88 Chronically Psychotic Patients

“…ing treatment adherence include the use of better-tolerated modern antipsychotic agents and of long-acting injectable antipsychotics [1,3,7,16,23,27,29,31,41,47,56,57] . Injectable, long-acting risperidone (RLAI; Risperdal Consta ® ) is the fi rst long-acting, second-generation antipsychotic drug.…”

Double‐blind therapeutic evaluation of fluspirilene compared with fluphenazine decanoate in chronic schizophrenics

“…The continuous progress in psychopharmacology and the development of potent neuroleptics have led to a faster rehabilitation and to a more rapid release of the psychotics from the hospitals. However, the relapse rate of these patients is high, either because they refuse to follow their maintenance therapy due to lack of insight, to side effects and to multiple daily doses or because they are inadequately treated by underdosage (Ayd (1971), Groves & Mandel (1975)).…”