Depression, the Metabolic Syndrome and Cardiovascular Risk

Vaccarino, Viola; McClure, Candace; Johnson, B. Delia; Sheps, David S.; Bittner, Vera; Rutledge, Thomas; Shaw, Leslee J.; Sopko, George; Olson, Marian B.; Krantz, David S.; Parashar, Susmita; Marroquin, Oscar C.; Merz, C. Noel Bairey

doi:10.1097/psy.0b013e31815c1b85

Cited by 163 publications

(147 citation statements)

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“…6 Third, mental disorders and PTSD may cause biological and behavioral changes that increase the risk of physical disease, leading to greater medical utilization. 28 , 29,[12][13][14][30][31][32][33][34] Finally, there may be an increased likelihood of detection of medical problems in veterans with mental health problems, for example, through symptoms identified by mental health providers. Veterans with comorbid mental and physical problems may also be more likely to enroll in primary care, which could lead to increased utilization of other services, such as preventive screening through laboratory and diagnostic tests.…”

Section: Discussionmentioning

confidence: 99%

Mental health diagnoses and utilization of VA non-mental health medical services among returning Iraq and Afghanistan veterans

Cohen¹,

Gima²,

Bertenthal³

et al. 2010

PsycEXTRA Dataset

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Section: Discussionmentioning

confidence: 99%

Mental health diagnoses and utilization of VA non-mental health medical services among returning Iraq and Afghanistan veterans

Cohen¹,

Gima²,

Bertenthal³

et al. 2010

PsycEXTRA Dataset

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“…Many studies have demonstrated that depressive symptoms are also related to such factors. Patients with elevated depressive symptoms may have not only unhealthy lifestyles but allostasis including autonomic nervous system dysregulation, which may lead to metabolic abnormalities such as increased visceral adiposity, dyslipidemia, elevated blood pressure, and insulin resistance (4,21). A previous study suggested that autonomic nervous system dysregulation was independently associated with the presence of metabolic syndrome, the number of metabolic dysregulation as well as all individual components except for HDL cholesterol (22).…”

Section: Discussionmentioning

confidence: 99%

“…Many clinical studies have shown that depression is a major predictor of cardiovascular outcomes (2,3). Research suggests that one plausible potential mechanism is derived from metabolic syndrome (4). This syndrome is noted worldwide as a possible cause of atherosclerotic cardiovascular disease, and consists of atherogenic dyslipidemia, elevated blood pressure, increased glucose concentration, as well as prothrombotic and proinflammatory states (5,6).…”

Section: Introductionmentioning

confidence: 99%

Elevated Depressive Symptoms are Associated with Hypertriglyceridemia in Japanese Male Workers

et al. 2011

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Objective The aim of this study was to determine whether elevated depressive symptoms are associated with metabolic syndrome and its components in the Japanese population. Methods Out of 1,386 male workers who underwent measurements of variables of metabolic syndrome components in their health checkup, 1,186 subjects (44.5 ± 9.6 years) completed the Zung self-rating depression scale (ZSDS) (response rate 85.6%). In this study, metabolic syndrome was defined according to the joint scientific statement proposed by 6 major organizations, including the International Diabetes Federation. Results The overall frequency of elevated depressive symptoms (ZSDS scores !40) was 42.1% (n=499). The incidence of metabolic syndrome was significantly higher in subjects with elevated depressive symptoms than in those without (13.2% vs. 8.9%, p<0.05). Of all the metabolic syndrome components, mean triglyceride levels were significantly higher in subjects with elevated depressive symptoms than in those without [124.7 (95% confidence interval (CI): 117.8-131.7) mg/dL vs. 111.5 (95% CI: 107.2-115.9) mg/dL, p<0.05]. Consequently, hypertriglyceridemia (28.9% vs. 21.0%, p<0.01) was the main component correlated with the between-group difference of metabolic syndrome incidence. In the logistic regression analysis after adjustment for potential confounders, the odds ratio of the total ZSDS scores for the diagnosis of hypertriglyceridemia was 1.52 (95% CI: 1.13-2.04; p<0.01), and the major depressive symptom was psychomotor agitation (odds ratio: 1.47; 95% CI: 1.10-1.94; p<0.01). Conclusion This study showed that elevated depressive symptoms were associated with hypertriglyceridemia in Japanese male workers, which affected the clinical diagnosis of metabolic syndrome.

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“…Hronični stres, taloženjem abdominalne masti, klinički se manifestuje nelagodnočću u stomaku, glavoboljom, nesanicom, osećajem straha, depresijom, osećajem ljutnje, hipertenzijom, hemoroidima, itd. [43,44]. Epidemiološke studije su jasno pokazale jasnu vezu između psiholoških faktora i kardiovaskularnih bolesti ali postoji izražena sumnja o tome da li je ova pojava uzročno-posledično povezana, odnosno, nije jasno kako se psihosocijalni faktori uklapaju u ovu sliku.…”

Section: Gojaznost I Stresunclassified

The cultural and medical determination of the obesity

Stolić¹

2015

Praxis Med

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SAŽETAKSavremeni aspekti društvenog razvoja sa sobom donosi nove preokupacije koje doprinose pojavi gojaznosti, kao direktnu posledicu sveukupnog izobilja. Skoro da postoji deklarativno usaglašen stav da gojaznost, prema svojoj učestalosti, predstavlja globalnu epidemiju novog milenijuma a da je zbog posledica na sveukupno zdravlje neophodan komplementaran multidisciplinaran pristup, jer se njenom prevencijom može sprečiti i znatno umanjiti stopa mortaliteta. Tehnološki razvoj, automatizacija u proizvodnji hrane, smanjeno učešće manuelnog rada i sedanterni način života, uslovljava porast gojaznih, ne samo u visoko industrijalizovanim već u manje razvijenim državama. Gojaznost predstavlja direktnu promociju iskušenja savremene civilizacije i veliki izazov za jednu zajednicu u kojoj hrane ima u izobilju. Ovakva činjenica povećava odgovornost svakog pojedinca i stavlja pred njim obavezu da prepozna uzroke gojaznosti kako bi, promenom sopstvenog ponašanja, mogao da smanji lični teret koji sa sobom nosi gojaznost.Ključne reči: gojaznost, društvo, epidemiologija, demografija, komorbiditeti, masno tkivo, stres UVODIstorijski posmatrano, gojaznost je najčešći i najduže poznati metabolički poremećaj kod ljudi, koji je u početku bio statusni simbol i nije se posmatrao niti kao zdravstveni problem, niti kao estetski nedostatak. Definiše se akumulacijom viška telesne masti, kao rezultat neravnoteže između energetskog unosa i njenog utroška, uzimajući u obzir pol, uzrast i telesnu visinu. Kao hronično oboljenje, gojaznost izaziva frustraciju i kod bolesnika i kod lekara, zbog značajnih zdravstvenih komplikacija koje umanjuju kvalitet života, skraćuje životni vek a lečenje gojaznih ima visoku cenu [1,2,3,4]. Energetski višak od 10 kalorija stvara uslove za dnevno povećanje telesne težine za 0,45 kg, sve u skladu sa prvim zakonom termodinamike koji kaže da se višak stvorene energije skladišti u masnom tkivu, jetri, mišićima, pankreasu i u svim drugim organima koji su uključeni u metabolička zbivanja u organizmu [4].Gojaznost se može tretirati i kao višegenska bolest u 25-70% slušajeva ali su njena genetska određenja dosta složena i nisu najbolje razjašnjena. Ipak, zbog individualnih razlika ona se smatra genetski uslovljenom kod 25-40% bolesnika. Isto tako, navodi snažan genski uticaj na raspodelu masti, što znači da je individualni genotip važna odrednica adaptiranja na višak unete energije. U tom smislu postoje podaci koji ukazuju da, kada određena populacija promeni svoj ambijent u ekonomski razvijeniju sredinu, nastaje značajan porast telesne težine, što potvrđuje važnost uticaja okruženja na pojavu gojaznosti. Zapravo, u većini slučajeva, geni koji su uključeni u gojaznost nisu direktni učesnici nastanka ovog oboljenja, već samo predisponiraju prijemčljivost za stvaranje masnog tkiva. Zbog toga se može zaključiti da gojaznost nastaje kao rezultat uticaja genetskih predispozicija ali i kao obrazac individualnog ponašanja, ne isključujući uticaj okruženja, fizioloških, kulturoloških i socijalnih faktora [5].Istraživanjem u ...

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Depression, the Metabolic Syndrome and Cardiovascular Risk

Abstract: In women with suspected coronary artery disease, the metabolic syndrome is independently associated with depression but explains only a small portion of the association between depression and incident CVD.

Cited by 163 publications

References 37 publications

Mental health diagnoses and utilization of VA non-mental health medical services among returning Iraq and Afghanistan veterans

Mental health diagnoses and utilization of VA non-mental health medical services among returning Iraq and Afghanistan veterans

Elevated Depressive Symptoms are Associated with Hypertriglyceridemia in Japanese Male Workers

The cultural and medical determination of the obesity

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