Depression predicts disability in long-term chronic pain patients

Ericsson, Martin; Poston, Walker S. C.; Linder, Jürgen; Taylor, J. Edward; Haddock, C. Keith; Foreyt, John P.

doi:10.1080/09638280110096241

Cited by 106 publications

(69 citation statements)

References 27 publications

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“…The results of our study accord with prior data indicating that when depression occurs in conjunction with another disorder, health outcomes are worsened and disability is increased [6][7][8][9][10]14]. The effects of comorbidity in SD have been rarely studied, in part, because a sample of large enough size with this diagnosis has not been available.…”

Section: Discussionsupporting

confidence: 81%

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The Effect of Depression Comorbid with Somatization Disorder: An Empirical Investigation

L¹,

Allen²

2015

Clin Psychiatry

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The present study investigated the effects of comorbid major depression in a sample of 175 patients diagnosed with somatization disorder (SD) as defined in DSM-IV. Comparisons were made between SD with current comorbid major depressive disorder and SD without current depression comorbidity. The data indicated that both a diagnosis of comorbid major depressive disorder and the presence of depression symptoms predicted greater disability and more impaired functioning. The results of the study are discussed and interpreted.

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Section: Discussionsupporting

confidence: 81%

“…In the present study, we sought to examine the whether comorbid depression was associated with functioning and disability in a sample of patients diagnosed with SD. We hypothesized that patients with SD comorbid with MDD would exhibit higher levels of impairment and disability than would patients with SD alone [14].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Depression Comorbid with Somatization Disorder: An Empirical Investigation

L¹,

Allen²

2015

Clin Psychiatry

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“…In clinical management of chronic pain, a bio-psycho-social model (Gatchel et al, 2007) is preferred since the above mentioned complex blend of factors -neurobiological, psychological (e.g., depression, catastrophizing, and anxiety), coping styles, and contextual factors -contribute to the development and maintenance of chronic pain (Alonso et al, 2004;Asmundson & Katz, 2009;Börsbo et al, 2008;Dersh et al, 2001;Ericsson et al, 2002;MeansChristensen et al, 2008;Ocañez et al, 2010;Sofat et al, 2011;Sullivan et al, 2001). …”

Section: The Bio-psycho-social Model Of Chronic Painmentioning

confidence: 99%

Potential Muscle Biomarkers of Chronic Myalgia in Humans - A Systematic Review of Microdialysis Studies

Gerdle¹,

Larsson²

2012

Biomarker

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“…Alterations in the circuitry that controls defensive responding are implicated in conditions such as fear, anxiety, depression and anger (Dixon, 1998;Adamec and Young, 2000). These secondary emotional reactions are components of the human pain experience, and contribute to the suffering and disability associated with pain (Crombez et al, 1999;Strahl et al, 2000;Ericsson et al, 2002). Gaining an understanding of the neural circuitry that controls the innate affective reaction to pain and how changes in this circuitry produces enduring effects on the individual is of obvious clinical importance and warrants additional study.…”

Section: Discussionmentioning

confidence: 99%

Contribution of the ventromedial hypothalamus to generation of the affective dimension of pain

Borszcz

2006

Pain

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The ventromedial hypothalamus (VMH) is a core structure underlying the generation of affective behaviors to threats. The prototypical threat to an individual is exposure to a noxious stimulus and the dorsomedial division of the VMH (dmVMH) receives nociceptive input. The present study evaluated the contribution of the dmVMH to generation of the affective reaction to pain in rats. Noxious tailshock elicits from rats vocalization afterdischarges (VADs) that have distinct spectrographic characteristics and are a validated model of the affective reaction to pain. VAD-like vocalizations (vocalizations with the same spectral characteristics of VADs) were elicited by stimulation (electrical or chemical) of the dmVMH. Stimulation in the vicinity of the dmVMH was ineffective in eliciting VADs. Manipulation of GABA A neurochemistry within the dmVMH altered the threshold for elicitation of VADs by dmVMH stimulation or tailshock. Administration of the GABA A antagonist bicuculline or the GABA A agonist muscimol into the dmVMH lowered and elevated VAD thresholds, respectively. These treatments did not alter thresholds of other tailshock elicited responses (vocalizations during tailshock or spinal motor reflexes). Bicuculline and muscimol administered into the dmVMH also elevated and lowered the asymptotic level of fear conditioning supported by dmVMH stimulation or tailshock. These findings demonstrate that the dmVMH contributes to the processing of pain affect and that the affective dimension of pain belongs to a broader class of sensory experience that represents threat to the individual.

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Depression predicts disability in long-term chronic pain patients

Abstract: These data suggest that depression, but not personality disorders characteristics, was an important disability predictor in chronic pain patients with extended follow-up.

Cited by 106 publications

References 27 publications

The Effect of Depression Comorbid with Somatization Disorder: An Empirical Investigation

The Effect of Depression Comorbid with Somatization Disorder: An Empirical Investigation

Potential Muscle Biomarkers of Chronic Myalgia in Humans - A Systematic Review of Microdialysis Studies

Contribution of the ventromedial hypothalamus to generation of the affective dimension of pain

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