Depression of Peripheral Lymphocyte Proliferation and Hemolytic Antibody Production in Passively Enhanced Rat Renal Allograft Recipients

Abstract

Specific suppression of renal allograft rejection in two strain combinations of rats by passive enhancement was associated with depression of both peripheral lymphocyte proliferation and hemolytic antibody production. Variations in these responses were related to allograft survival in individual rats. In general, these studies confirm the value of monitoring both the lymphocyte proliferation and hemolytic antibody responses for the prediction of subsequent rejection, and for evaluating the efficacy of the enhancement therapy.