Depression of pancreatic bicarbonate response during endotoxic shock in dogs

Greenberg, L; Shimo-Takahara, Steven

doi:10.1016/0022-4804(76)90167-0

Cited by 3 publications

(1 citation statement)

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“…Also, there is evidence to indicate that the horse pancreas secretes a sodium-rich fluid (Alexander and Hickson 1970). Lipopolysaccharide would be expected to decrease pancreatic secretion since a depression of pancreatic bicarbonate secretion has been reported in dogs during endotoxic shock (Greenberg and Shimo-Takahara 1976). However, the effect of LPS on pancreatic secretion in horses is unknown.…”

Section: Ta B L E 1: Concentrations and Outputs Of Hydrogen Ions In Gmentioning

confidence: 99%

Effects of lipopolysaccharide and phenylbutazone on gastric contents in the horse

Doherty

Andrews²,

Blackford³

et al. 2003

Equine Veterinary Journal

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Reasons for performing study: Endotoxaemia causes a disruption of gastrointestinal motility in the horse but there is no information on its effects on gastric secre t i o n . Lipopolysaccharide (LPS) administration is known to affect gastric secretion in other species. Hypothesis: That LPS, a toxic component of Gram-negative bacteria, would reduce gastric acid secretion and that pretreatment with phenylbutazone (PBZ) would block the effects of LPS. Methods: The effects of LPS and PBZ on gastric contents were investigated in fasted, mature horses, with permanent gastric cannulae. Horses were pre t reated with either saline or PBZ 15 mins before a 60 min infusion of either LPS or s a l i n e . Gastric contents were collected at 15 min intervals for 3 h, beginning 15 mins after the start of the LPS or saline infusion. R e s u l t s : Lipopolysaccharide significantly decreased gastric acid output, [K + ] and potassium output and increased [Na + ] and sodium output. Phenylbutazone did not affect basal gastric acid secretion but decreased LPS-induced changes in the s e c reted volume, [Na + ] and sodium output. C o n c l u s i o n s :This study provides evidence that LPS aff e c t s gastric acid secretion in the horse and that these LPS-induced changes are mediated, in part, by pro s t a g l a n d i n s . Potential relevance: L i p o p o l y s a c c h a r i d e administration caninduce changes in the composition of gastric contents in the horse but furt h e r work is needed to determine the source of these changes.

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Section: Ta B L E 1: Concentrations and Outputs Of Hydrogen Ions In Gmentioning

confidence: 99%