Depression of Cellular Immunity after Multiple Trauma in the Absence of Sepsis

U.S. Army Institute of Surgical Research Annual Research Progress Report for Fiscal Year 1989

“…This rise apparently could be brought forward into the end of the light phase (19). Exposure of animals to light from the beginning of the night did not prevent a rise in pineal MEL by 6 h after beginning two-hourly injections of ISO at the expected onset of darkness (15). Thus, prolonged systemic beta-adrenergic stimulation may activate whatever factor produces pineal responsiveness.…”

“…Two recent reports show an advancement in the time of the pineal MEL surge after multiple ISO or forskolin injections in the light phase (15,19). This rise apparently could be brought forward into the end of the light phase (19).…”

“…However, if hamsters are deprived of darkness (by exposure to light) for the first 6 h or more of the night, then a response to agonist (by 4 h) does not develop or is attenuated (8,11) or may be delayed to 6-8 h after multiple injections (15).…”

“…For a given level of PEEP, peak airway pressure is significantly less for HFV than conventional ventilation, thus conceivably reducing the risk of barotrauma (2,(13)(14)(15). Also, smaller fluctuations in peak airway pressure and mean airway pressure associated with HFV may have less effect on hemodynamic function.…”

“…Such granulocyte dysfunction may contribute significantly to the marked predisposition to infection (15).…”