Continuum and emission-line variability of active galactic nuclei provides a powerful probe of microarcsecond scale structures in the central regions of these sources. In this contribution, we review basic concepts and methodologies used in analyzing AGN variability. We develop from first principles the basics of reverberation mapping, and pay special attention to emission-line transfer functions. We discuss application of cross-correlation analysis to AGN light curves. Finally, we provide a short review of recent important results in the field.

An increase in serum sodium concentration significantly decreases ICP and increases CPP. Hypertonic saline is an effective agent to increase serum sodium concentrations. Sustained hypernatremia and hyperosmolarity are safely tolerated in pediatric patients with traumatic brain injury. Controlled trials are needed before recommendation of widespread use.

We report the results of intensive X-ray, UV and optical monitoring of the Seyfert 1 galaxy NGC 4593 with Swift. There is no intrinsic flux-related spectral change in the the variable components in any band with small apparent variations due only to contamination by a second constant component, possibly a (hard) reflection component in the X-rays and the (red) host galaxy in the UV/optical bands. Relative to the shortest wavelength band, UVW2, the lags of the other UV and optical bands are mostly in agreement with the predictions of reprocessing of high energy emission from an accretion disc. The U-band lag is, however, far larger than expected, almost certainly because of reprocessed Balmer continuum emission from the more distant broad line region gas. The UVW2 band is well correlated with the X-rays but lags by ∼ 6× more than expected if the UVW2 results from reprocessing of X-rays on the accretion disc. However, if the lightcurves are filtered to remove variations on timescales > 5d, the lag approaches the expectation from disc reprocessing. MEMEcho analysis shows that direct X-rays can be the driver of most of the variations in the UV/optical bands as long as the response functions for those bands all have long tails (up to 10d) in addition to a strong peak (from disc reprocessing) at short lag (< 1 d). We interpret the tails as due to reprocessing from the surrounding gas. Comparison of X-ray to UVW2 and UVW2 to V-band lags for 4 AGN, including NGC 4593, shows that all have UVW2 to V-band lags which exceed the expectations from disc resprocessing by ∼ < 2. However the X-ray to UVW2 lags are, mostly, in greater excess from the expectations from disc reprocessing and differ between AGN. The largest excess is in NGC 4151. Absorption and scattering may be affecting X-ray to UV lags.

We present reverberation-mapping lags and black-hole mass measurements using the C ivλ1549 broad emission line from a sample of 349 quasars monitored as a part of the Sloan Digital Sky Survey Reverberation Mapping Project. Our data span four years of spectroscopic and photometric monitoring for a total baseline of 1300 days. We report significant time delays between the continuum and the C ivλ1549 emission line in 52 quasars, with an estimated false-positive detection rate of 10%. Our analysis of marginal lag measurements indicates that there are on the order of ∼100 additional lags that should be recoverable by adding more years of data from the program. We use our measurements to calculate black-hole masses and fit an updated C iv radius-luminosity relationship. Our results significantly increase the sample of quasars with C iv RM results, with the quasars spanning two orders of magnitude in luminosity toward the high-luminosity end of the C iv radius-luminosity relation. In addition, these quasars are located at among the highest redshifts (z ≈ 1.4-2.8) of quasars with black hole masses measured with reverberation mapping. This work constitutes the first large sample of C iv reverberation-mapping measurements in more than a dozen quasars, demonstrating the utility of multi-object reverberation mapping campaigns.

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Hypertonic saline administration to children with closed head injury appears to be a promising therapy for control of cerebral edema. Further controlled trials are required to determine the optimal duration of treatment before widespread use is advocated.

We have recently initiated the first spectroscopic dust reverberation programme on active galactic nuclei (AGN) in the near-infrared. Spectroscopy enables measurement of dust properties, such as flux, temperature and covering factor, with higher precision than photometry. In particular, it enables measurement of both luminosity-based dust radii and dust response times. Here we report results from a one-year campaign on NGC 5548. The hot dust responds to changes in the irradiating flux with a lag time of ∼ 70 light-days, similar to what was previously found in photometric reverberation campaigns. The mean and rms spectra are similar, implying that the same dust component dominates both the emission and the variations. The dust lag time is consistent with the luminosity-based dust radius only if we assume a wavelengthindependent dust emissivity-law, i.e. a blackbody, which is appropriate for grains of large sizes (of a few µm). For such grains the dust temperature is ∼ 1450 K. Therefore, silicate grains have most likely evaporated and carbon is the main chemical component. But the hot dust is not close to its sublimation temperature, contrary to popular belief. This is further supported by our observation of temperature variations largely consistent with a heating/cooling process. Therefore, the inner dust-free region is enlarged and the dusty torus rather a "dusty wall", whose inner radius is expected to be luminosity-invariant. The dust-destruction mechanism that enlarges the dust-free region seems to partly affect also the dusty region. We observe a cyclical decrease in dust mass with implied dust reformation times of ∼ 5 − 6 months.

We present the first results from a high sampling rate, multi-month reverberation mapping campaign undertaken primarily at MDM Observatory with