Depression, Is It Treatable in Adults Utilising Dietary Interventions? A Systematic Review of Randomised Controlled Trials

O’Neill, Simone; Minehan, Michelle; Knight-Agarwal, Cathy; Turner, Murray

doi:10.3390/nu14071398

Cited by 15 publications

(15 citation statements)

References 51 publications

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“…More recently, the impact of poor diet quality and nutritional inadequacies on mental health and mental illness has gained considerable attention [18]. Diet quality is inversely associated with depressive symptoms and incident depression [19], with a whole-of-diet approach being effective in reducing depressive symptoms [20,21] and cost-effective in terms of QALYs [22,23].…”

Section: Introductionmentioning

confidence: 99%

Implications of Dietary Intake and Eating Behaviors for People with Serious Mental Illness: A Qualitative Study

et al. 2022

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The impact of poor diet quality and nutritional inadequacies on mental health and mental illness has recently gained considerable attention in science. As the opinions and experiences of people living with serious mental illness on dietary issues are unknown, we aimed to understand the role of nutrition in a biopsychosocial approach. In total, 28 semi-structured interviews were conducted with people living with serious mental illness (SMI) in Australia, Germany and Austria, and a generic thematic analysis approach was applied. Four positive (positive effects on the body and mind, therapeutic effects in treating somatic illnesses, pleasure and opportunity for self-efficacy) and three negative (impairment related to mental illness and its treatment, perceived stigma and negative effects on the body and mind) implications of diet were identified. A key issue for most of the participants was the mental burden arising from their body weight. This might indicate that negative implications, such as guilt and stigma, were of primary importance for people with SMI when talking about their dietary behavior. In conclusion, diet-related support is urgently needed for people with SMI. However, especially participants from Germany and Austria reported that this is not yet widely available in mental health settings, leading to hopelessness and resignation.

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Section: Introductionmentioning

confidence: 99%

Implications of Dietary Intake and Eating Behaviors for People with Serious Mental Illness: A Qualitative Study

et al. 2022

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“…From a disease control point of view, dietary nutrition is an important aspect of disease prevention and improvement [29]. Associations between diet, obesity and the related metabolic syndrome (MetS), stress, and mental disorders exist [30].…”

Section: Discussionmentioning

confidence: 99%

Association between dietary protein intake and depression in American adults with metabolic syndrome

Shen

Liu

et al. 2023

Preprint

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Background There is currently intense interest in the effects of macronutrients on mental disorders. The purpose of the study was to analyze the relationship between depression and protein intake in people with metabolic syndrome. Methods The study analyzed data on 7922 individuals with metabolic syndrome that were derived from the National Health and Nutrition Examination Survey (NHANES)1999–2018. To test whether the investigated variables differed significantly, variance and the chi-squared test were used to analyze dietary protein intake among groups. Variables with significant differences were selected for multiple logistic regression analysis to further explore the associations between PHQ-9 defined depressive symptoms and protein. Smoothed curve fitting was employed to determine whether if there was a nonlinear correlation between the two. Results As protein eaten increased, the number of participants suffering from depression decreased. After adjusting for confounding variables (eGFR, cancer, thyroid disease, total energy, carbohydrate, fiber, calcium, caffeine intake, magnesium, and general information), multivariate logistic regression analysis indicated that dietary protein may serve as a protective factor for depression. Moreover, a negative nonlinear association between depression and dietary protein was found. Conclusion These findings indicate that for individuals with metabolic syndrome dietary protein is relevant to depression.

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“…Particularly, only RCTs can overcome the epistemological problems of dietary measurement error and form a sounder basis for informing dietary recommendations in human nutrition [ 23 ]. Previous systematic reviews of RCTs have analyzed the diet–depression association [ 24 , 25 , 26 ] but did not specifically examine MD as the exposure [ 25 , 26 ], did not consider adults with a diagnosis of depression [ 24 , 25 ], and did not perform a meta-analysis [ 24 , 25 , 26 ]. Moreover, in a preliminary search, new evidence from RCTs [ 27 , 28 , 29 ] was found, indicating that an update is required to help clinicians determine the extent to which MD should be recommended in the treatment of patients with depressive disorders.…”

Section: Introductionmentioning

confidence: 99%

Mediterranean Diet Interventions for Depressive Symptoms in Adults with Depressive Disorders: A Protocol for a Systematic Review and Meta-Analysis

Bizzozero-Peroni

Godoy-Cumillaf

Fernández‐Rodríguez

et al. 2022

IJERPH

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The associations between Mediterranean diet (MD) adherence and depression levels have been synthesized from observational studies. However, a systematic review with meta-analysis including randomized controlled trials (RCTs) on this relationship in adults with depressive disorders remains lacking. This protocol was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analysis for Protocols statement. MEDLINE (PubMed), Cochrane CENTRAL, PsycINFO, Scopus, and Web of Science databases will be systematically searched to identify studies published from database inception up to 30 September 2022. The inclusion criteria will comprise RCTs reporting pre-post changes in depression status (symptoms or remission) after a MD intervention compared to a control condition in adults over 18 years with depressive disorders. Pooled effect sizes and 95% confidence intervals will be calculated using the DerSimonian random-effects model. This study protocol determines the methodological approach for the systematic review and meta-analysis that will summarize the available evidence on the efficacy of MD interventions on depressive symptoms in adults with depressive disorders. The findings from this review may have implications for public mental health programs. The results will be disseminated through peer-reviewed publication, conference presentation, and infographics. No ethical approval will be required since only published data will be used. PROSPERO registration number: CRD42022341895.

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Depression, Is It Treatable in Adults Utilising Dietary Interventions? A Systematic Review of Randomised Controlled Trials

Cited by 15 publications

References 51 publications

Implications of Dietary Intake and Eating Behaviors for People with Serious Mental Illness: A Qualitative Study

Implications of Dietary Intake and Eating Behaviors for People with Serious Mental Illness: A Qualitative Study

Association between dietary protein intake and depression in American adults with metabolic syndrome

Mediterranean Diet Interventions for Depressive Symptoms in Adults with Depressive Disorders: A Protocol for a Systematic Review and Meta-Analysis

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