Mediterranean Diet Interventions for Depressive Symptoms in Adults with Depressive Disorders: A Protocol for a Systematic Review and Meta-Analysis

Bizzozero-Peroni, Bruno; Godoy-Cumillaf, Andrés; Fernández‐Rodríguez, Rubén; Rodríguez‐Gutiérrez, Eva; Jiménez‐López, Estela; Giakoni-Ramírez, Frano; Duclos-Bastías, Daniel; Mesas, Arthur Eumann

doi:10.3390/ijerph192114437

Cited by 2 publications

(1 citation statement)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neurotransmitter i mbalance Modified Mediterranean diet [164] Diet rich in tryptophan (10 mg/kg/day) [165] Correction of zinc deficiency [166] Vitamin B6 (80 mg/day) [167] L-theanine (200 mg/day) [168] Magnesium (300 mg/day) + vitamin B6 (30 mg/day) [169] Neuroinflammation Calorie restriction [170] Mediterranean diet [171] Omega-3 fatty acids (DHA 2 (720 mg/day) + EPA 1 (480 mg/day) [172] Correction of vitamin D deficiency [173] Gut-brain axis disturbance High intake of dietary fiber [174] Probiotics (Lactobacillus reuteri NK33 and Bifidobacterium adolescentis NK98) [175] Galactooligosaccharides (7.5 g/day) [176] 1 EPA-Eicosapentaenoic acid. 2 DHA-Docosahexaenoic acid.…”

Section: Dietary Patterns Nutrientsmentioning

confidence: 99%

Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders

Badaeva

Danilov

Clayton³

et al. 2023

Nutrients

View full text Add to dashboard Cite

The term neuronutrition has been proposed as part of nutritional neuroscience, studying the effects of various dietary components on behavior and cognition. Other researchers underline that neuronutrition includes the use of various nutrients and diets to prevent and treat neurological disorders. The aim of this narrative review was to explore the current understanding of the term neuronutrition as the key concept for brain health, its potential molecular targets, and perspectives of its nutritional approach to the prevention and treatment of Alzheimer’s and Parkinson’s diseases, multiple sclerosis, anxiety, depressive disorders, migraine, and chronic pain. Neuronutrition can be defined as a part of neuroscience that studies the influence of various aspects of nutrition (nutrients, diet, eating behavior, food environment, etc.) on the development of nervous disorders and includes nutrition, clinical dietetics, and neurology. There is evidence that the neuronutritional approach can influence neuroepigenetic modifications, immunological regulation, metabolic control, and behavioral patterns. The main molecular targets in neuronutrition include neuroinflammation, oxidative/nitrosative stress and mitochondrial dysfunction, gut–brain axis disturbance, and neurotransmitter imbalance. To effectively apply neuronutrition for maintaining brain health, a personalized approach is needed, which includes the adaptation of the scientific findings to the genetic, biochemical, psycho-physiological, and environmental features of each individual.

show abstract

Section: Dietary Patterns Nutrientsmentioning

confidence: 99%

Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders

Badaeva

Danilov

Clayton³

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

The impact of the Mediterranean diet on alleviating depressive symptoms in adults: a systematic review and meta-analysis of randomized controlled trials

Bizzozero-Peroni,

Martínez-Vizcaíno,

Fernández-Rodríguez

et al. 2024

Nutrition Reviews

View full text Add to dashboard Cite

Context High adherence to the Mediterranean diet (MD) has been associated with a reduced risk of depression in prospective cohort studies, but whether MD interventions are effective among adults with depression is uncertain. Objective This study aimed to synthesize findings on the effects of MD interventions on the severity of depressive symptoms in adults with depression. Data Sources PubMed, Cochrane CENTRAL, PsycINFO, Scopus, and Web of Science were systematically searched from database inception to March 2023. The Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines and the Cochrane recommendations were followed. We included randomized controlled trials (RCTs) comparing outcomes after MD interventions with outcomes for control conditions in adults with depressive disorders or depressive symptoms. Data Extraction Two authors extracted the data independently. The Sidik-Jonkman estimator, the I2 metric, and the prediction interval were used to estimate between-study heterogeneity. To determine the risk of bias and the certainty of evidence from RCTs, we used the Cochrane Collaboration’s Risk of Bias 2 and Grades of Recommendation, Assessment, Development, and Evaluation tools, respectively. Data Analysis In total, 1507 participants (mean age range: 22.0 years–53.3 years) with depression were initially included in the 5 RCTs of this review. Compared with control conditions, MD interventions significantly reduced depressive symptoms among young and middle-aged adults with major depression or mild to moderate depressive symptoms (standardized mean difference: –0.53; 95% confidence interval: –0.90 to –0.16; I2 = 87.1%). The prediction interval ranged from –1.86 to 0.81. The overall risk of bias was within the range of “some concerns” to “high,” while the certainty of evidence was low. Conclusion MD interventions appear to have substantial potential for alleviating depressive symptoms in people experiencing major or mild depression. However, to establish robust recommendations, there remains a need for high-quality, large-scale, and long-term RCTs. Systematic Review Registration PROSPERO registration no. CRD42022341895.

show abstract

Mediterranean Diet Interventions for Depressive Symptoms in Adults with Depressive Disorders: A Protocol for a Systematic Review and Meta-Analysis

Cited by 2 publications

References 50 publications

Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders

Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders

The impact of the Mediterranean diet on alleviating depressive symptoms in adults: a systematic review and meta-analysis of randomized controlled trials

Contact Info

Product

Resources

About