Depression in systemic lupus erythematosus: A systematic review

Gupta, Mridul

doi:10.4103/2321-6662.210493

Cited by 6 publications

(13 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Depression is the most frequent among neuropsychiatric manifestation complaints in patients with Systemic Lupus Erythematosus (SLE) [1,2] that impairs daily living for sufferers and causes significant societal and economic burden [3,4]. The high incidence and increasing prevalence of depression in patients with SLE has been recognized as a severe mental health problem of noncommunicable diseases (NCDs) of the twenty-first century [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…The high incidence and increasing prevalence of depression in patients with SLE has been recognized as a severe mental health problem of noncommunicable diseases (NCDs) of the twenty-first century [5,6]. Point prevalence rates range from 2 to 91.7%, depending upon the context, setting, and assessment tool [2,7]. Eight to 24% of patients were diagnosed with depressive disorders [7,8], and 12% had suicidal thoughts [9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and biopsychosocial factors associated with depressive symptoms among patients living with systemic lupus erythematosus in clinical settings in urban Thailand

2022

View full text Add to dashboard Cite

Background Depressive symptoms are globally recognized as a significant mental health problem in patients with chronic disease, particularly those with systemic lupus erythematosus (SLE). The purpose of this study was to estimate the prevalence and examine biopsychosocial factors of depressive symptoms among patients with SLE. Methods This cross-sectional study was conducted among 185 participants diagnosed with SLE and received treatment for at least 3 months, aged 18–59 years attending the outpatient clinic of a university hospital, Bangkok, Thailand. Depressive symptoms were measured by the Thai version of the Patient Health Questionnaire-9. We assessed Demographic data, the Systemic Lupus Erythematosus Activity Index, the Systemic Lupus International Collaborating Clinics Damage Index, Numeric Rating Scale, Fatigue Severity Scale, Body Image Scale, and the ENRICHD Social Support Instrument. Data were collected from March to May 2021. Multivariable logistic regression was used to analyze the data. Results The proportion of the participants with depressive symptoms was 43.2%, which 8.1% of those patients presented moderate to severe depressive symptoms. In a multivariable logistic regression model, SLE patients with depressive symptoms were more likely to be severe pain (aOR = 12.11, 95% CI: 1.35, 108.46), fatigue (aOR = 2.36, 95%CI: 1.08, 5.14), taking prednisolone ≥15 mg daily (aOR = 5.75, 95%CI: 1.76, 18.80), low satisfied of body image (aOR = 12.49, 95%CI: 2.23, 69.80), and low social support (aOR = 17.96, 95% CI: 1.86, 173.77). Disease flare, organ damage, and family income sufficiency did not significantly increase the risk of depressive symptoms in patients with SLE. Conclusions The findings highlight depressive symptoms in patients with SLE. Therefore, the health professional should be concerned about the perception of body image, level of social support, fatigue, and pain while treating patients with SLE. Public health screening programs to identify depressive symptoms in patients with SLE are needed. In addition, a high dose of prednisolone should be considered if required, along with monitoring.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence and biopsychosocial factors associated with depressive symptoms among patients living with systemic lupus erythematosus in clinical settings in urban Thailand

2022

View full text Add to dashboard Cite

show abstract

“…Diabetes mellitus, vascular disease, unemployment, and low levels of education are also found to be associated with depression in isolated studies. 10 Suicidal risk is high in these patients. 11 Psychotic spectrum disorders in SLE is however not wellstudied.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychiatric manifestations associated with systemic lupus erythematosus: A case report and selective review of literature

Bhaumik¹,

Singh²

2020

TJP

View full text Add to dashboard Cite

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune condition affecting multiple organ systems including central nervous system. Its aetiology lies in abnormal antibody formation and complement activation. Neuropsychiatric manifestations are known to occur in patients with SLE, and vary from psychosis, depression, anxiety to cognitive impairment. Here we report a case of depression with psychotic symptoms and suicidal ideations associated with SLE. Case Summary: We present the case of a 30-year-old female who presented with irritability, crying spells, feeling of guilt, referential and persecutory ideations along with suicidal ideations. She was diagnosed with severe depression with psychotic symptoms associated with SLE. She improved over a period of 6 weeks with Quetiapine 300mg along with symptomatic management of underlying medical condition. Conclusions: Depression with psychotic symptoms is not an uncommon presentation of SLE. It needs comprehensive management and multidisciplinary approach. Hence physician has to be sensitized regarding neuropsychiatric manifestations of SLE for improving the morbidity and mortality associated with underlying depression.

show abstract

“…In lupus patients, increased depression causes increased disease activity, 37 likely due to neurotransmitter dysfunction and immune system activation as a result of abnormalities in lymphocytes and cytokine expression, 38,39 which cause more severe clinical manifestations 38,40 and increasing aches and wounds/pain 39,40 that result in disruption of daily activities which decreases the QoL of lupus patients. 38 In the maintenance, increased depression decreases the QoL's subscale of treatment. There is a strong association between depression and medication adherence, where patients reporting noncompliance tend to have a longer duration of disease than those reporting medication adherence, even after controlled disease activity.…”

Section: Discussionmentioning

confidence: 99%

<p>Effect of Mental Health Problems on the Quality of Life in Children with Lupus Nephritis</p>

Putera

Irwanto

Maramis

et al. 2020

NDT

View full text Add to dashboard Cite

Introduction: Mental health problems, such as anxiety, depression, and ineffective family coping, in children with lupus nephritis (LN) can increase the severity and affect the management of the disease, thus affecting the quality of life (QoL) of patients. Objective: Analyzing the association between levels of depression, anxiety, coping, disease activity on the QoL of pediatric patients with LN. Patients and Methods: There were 62 pediatric LN participants (16 participants in the induction phase and 46 participants in the maintenance phase). Participants were measured for anxiety, depression, coping, disease activity (systemic lupus erythematosus disease activity index/SLEDAI), and QoL. The measurement results were compared between induction and maintenance groups. Analysis of the association between anxiety, depression, coping, and disease activity with the QoL of children with LN used a multiple logistic regression test with p <0.05. Results:: The measurement results obtained anxiety (induction = 69.06±3.92 and maintenance = 45.24±10.33; p <0.001), depression (induction = 69.88±3.34 and maintenance = 42.20±9.12; p <0.001), coping (induction = 99.88±12.93 and maintenance = 115.67±7.34; p <0.001), SLEDAI (induction = 15.81±12.58 and maintenance = 0.43±1.26; p <0.001), and QoL (induction = 49.92 ±12.44 and maintenance = 88.15±8.06; p <0.001).. Anxiety level in the induction group (p = 0.043) and maintenance group (p <0.001; p = 0.032; p = 0.008; p = 0.009). Depression level in the induction group (p = 0.031) and maintenance group (p = 0.024; p = 0.042; p = 0.003). SLEDAI score in the maintenance group (p = 0.003; p = 0.003). Coping in induction group (p = 0.016; p = 0.016) and maintenance group (p = 0.005). Conclusion: Mental health disorders reduce the QoL of LN children, and the level of QoL in induction phase is lower than maintenance phase.

show abstract

Depression in systemic lupus erythematosus: A systematic review

Cited by 6 publications

References 5 publications

Prevalence and biopsychosocial factors associated with depressive symptoms among patients living with systemic lupus erythematosus in clinical settings in urban Thailand

Prevalence and biopsychosocial factors associated with depressive symptoms among patients living with systemic lupus erythematosus in clinical settings in urban Thailand

Neuropsychiatric manifestations associated with systemic lupus erythematosus: A case report and selective review of literature

<p>Effect of Mental Health Problems on the Quality of Life in Children with Lupus Nephritis</p>

Contact Info

Product

Resources

About