Depression in patients with acute traumatic brain injury

Federoff, J; Starstein, S; Forrester, Alfred W.; Geisler, Fred H.; Jorge, Ricardo E.; Arndt, Stephan; Robinson, R.

doi:10.1097/00001199-199309000-00019

Cited by 52 publications

(74 citation statements)

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“…This risk is similar to other patients who have received a serious injury such as traumatic brain injury. 36,51 Given the high prevalence of traumatic brain injury in people with SCI, research is needed to study the rates and nature of psychological morbidity in people with SCI who also have a comorbid traumatic brain injury. 52 No studies were found that used structured diagnostic clinical interviews to assess the rates of depressive disorder in people with SCI after they completed rehabilitation, that is, when they were living in the community.…”

Section: Discussionmentioning

confidence: 99%

Psychological morbidity and spinal cord injury: a systematic review

2008

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Study Design: A systematic review of the literature concerning the nature of the psychological morbidity in people with spinal cord injury (SCI). Objectives: SCI is believed to place the individual at a high risk of psychological morbidity. The objective of this paper was to examine systematically the prevalence of negative psychological states in people with SCI, as well as to explore mediating and contextual factors. Methods: Search engines such as Medline and PsycInfo were systematically searched using specific key words, such as SCI, depression, anxiety and so on. Only studies that fulfilled certain criteria such as the use of valid measures in assessing psychological morbidity were used in the review process. Results: The systematic review revealed that clarification is still needed concerning the psychological consequences of people with SCI. However, findings suggest that approximately 30% of people with SCI are at risk of having a depressive disorder although in rehabilitation, and approximately 27% are at risk of having raised depressive symptoms when living in the community. The review also established that people with SCI have higher comparative risks of anxiety disorder, elevated levels of anxiety, feelings of helplessness and poor quality of life (QOL). Conclusion: People with SCI have an increased risk of suffering debilitating levels of psychological morbidity. Future research needs to clarify the extent and nature of psychological morbidity following SCI by conducting prospective and comprehensive research in large heterogeneous samples of people with SCI during the rehabilitation phase and following reintegration into the community.

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Section: Discussionmentioning

confidence: 99%

Psychological morbidity and spinal cord injury: a systematic review

2008

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“…Increased mood symptoms following a TBI are believed to be caused by injuries to specific brain regions, particularly the anterior frontal lobe regions, which are areas that are heavily innervated by the serotoneric system [10][11][12]. Despite possible links with the serotonergic system, there is a paucity of data concerning efficacy and adverse effects for selectiveserotonin reuptake inhibitor (SSRI) treatment in depressed TBI patients.…”

Section: Introductionmentioning

confidence: 99%

Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury

Lanctôt¹,

Rapoport

Chan³

et al. 2010

Brain Injury

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Objectives-To determine which serotonergic system-related single nucleotide polymorphisms (SNPs) predicted variation in treatment response to citalopram in depression following a traumatic brain injury (TBI).Methods-Ninety (50 M/40 F, aged 39.9, SD = 18.0 years) post-TBI patients with a major depressive episode (MDE) were recruited into a 6-week open-label study of citalopram (20 mg/ day). Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value <0.025). Results-MTHFR CIHR Author Manuscript CIHR Author Manuscript CIHR Author ManuscriptConclusion-Results suggest that polymorphisms in genes related to the serotonergic system may help predict short-term response to citalopram and tolerability to the medication in patients with MDE following a TBI. KeywordsTraumatic brain injury; serotonin receptors; serotonin transporter; brain derived neurotrophic factor (BDNF); methylenetetrahydrofolate reductase (MTHFR); tryptophan hydroxylase (TPH)

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“…Investigations determining the relationship between specific regional brain injury and depressive symptoms have proven inconsistent. Studies have shown an association between post-TBI depression and lesions in the left dorsolateral prefrontal cortex and left basal ganglia in the acute phase of TBI (Fedoroff et al 1992). Jorge and colleagues (2004) found a reduction in the left prefrontal grey matter volume on MRI scanning, especially in the ventrolateral and dorsolateral regions, in patients with post-TBI depression.…”

Section: No Relationship Was Identified B E T W E E N D E V E L O Pmentioning

confidence: 99%