Depression in Parkinson's disease: A double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation

Silva, Ticyana Moralez da; Munhoz, Renato P.; Alvarez, Cristiano Estevez; Naliwaiko, Katya; Kiss, Ágata; Andreatini, Roberto; Ferraz, Anete Curte

doi:10.1016/j.jad.2008.03.008

Cited by 168 publications

(164 citation statements)

References 42 publications

Supporting

Mentioning

163

Contrasting

Order By: Relevance

“…It is worth mentioning a recent Brazilian study that demonstrated the efficacy of fish oil with omega-3 fatty acid as an antidepressant or as an adjunctive therapy for major depression in PD 26 . Repetitive transcranial magnetic stimulation possibly has the same antidepressant efficacy as fluoxetine and may also improve motor and cognitive performance 27 .…”

Section: Depressionmentioning

confidence: 99%

Neuropsychiatry of Parkinson's disease

Kümmer

Teixeira

2009

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-Parkinson's disease (PD) is traditionally regarded as a movement disorder. In recent years, however, non-motor symptoms have been considered significant factors of disability at all stages of the illness. Behavioral and psychological symptoms or neuropsychiatric syndromes associated with PD are frequent and may represent a challenge in the management of these patients. They include anxiety, depression, psychosis, sleep, sexual and impulse control disorders, apathy and cognitive dysfunction. Their pathogenesis in PD is complex, involving neurodegenerative, drug-related and psychological mechanisms. We will review the current knowledge of this growing field, also focusing on the management of theses syndromes.KEY WORDS: Parkinson's disease, neuropsychiatry, psychology, psychiatric disorders. Neuropsiquiatria da doença de ParkinsonResumo -A doença de Parkinson (DP) é tradicionalmente conhecida como um distúrbio do movimento. Entretanto, os sintomas não-motores têm sido considerados recentemente como fatores relevantes de incapacidade em todos os estágios da doença. Sintomas motores e comportamentais ou síndromes neuropsiquiátricas associadas à DP são frequentes e seu manejo pode se tornar um verdadeiro desafio. São comuns quadros de ansiedade, depressão, psicose, distúrbios do sono, transtornos do controle do impulso, apatia e disfunções cognitivas. A patogênese desses transtornos na DP é complexa, envolvendo mecanismos degenerativos, psicológicos e relacionados ao tratamento. Neste artigo, revisamos o estado do conhecimento desse campo de interesse crescente, também enfocando o manejo dessas síndromes. PALAVRAS-CHAVE: doença de Parkinson, neuropsiquiatria, psicologia, transtornos psiquiátricos.

show abstract

Section: Depressionmentioning

confidence: 99%

Neuropsychiatry of Parkinson's disease

Kümmer

Teixeira

2009

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…Omega-3 PUFAs and fish oil, the major dietary source of Omega-3 PUFA have been extensively studied as dietary supplements suggesting beneficial effects for the treatment of inflammation [67][68][69], macular degeneration [70,71], AD [72][73][74][75] depression [76] anxiety disorders [77], and psychotic disorders [78]. Optimum maintenance of the synaptosome, brain cell functions, and general health of human CNS are potentially facilitated by Omega-3 PUFA [79][80][81].…”

Section: Aarti and Priyankamentioning

confidence: 99%

Review on Therapeutic Effects Mediated by Omega-3 Fatty Acids in Alzheimer’s Disease

Sati

Bhatt²

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Alzheimer's disease (AD) is a neurodegenerative disorder with relevant unmet therapeutic needs. Both natural aging and AD have been associated with a significant decline in the Omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA), and accordingly, administration of DHA has been proposed as a possible treatment for this pathology. DHA and its derivatives like 2-hydroxy DHA-(OHDHA) have a strong therapeutic potential to treat AD. Studies have demonstrated that DHA induced lipid modifications are paralleled with a reduction in amyloid-beta (Αβ) accumulation and full recovery of cognitive impairment. Omega-3 fatty acids also caused alterations in the subcellular distribution of secretases and reduced Αβ-induced tau protein phosphorylation as well. Furthermore, OHDHA enhanced the survival of neuron-like differentiated cells exposed to different insults such as oligomeric Αβ and N-methyl-D-aspartate-mediated neurotoxicity. In conclusion, this review focuses on the pleiotropic effects of Omega-3 fatty acids that might prove beneficial to treat AD.

show abstract

“…Clinical studies: Excepting for one study which showed that supplementation with omega-3 PUFA reduced depression in PD patients [52], there are no studies describing the neuroprotective effects of PUFA in PD patients. Hence more systematic research is warranted to establish their beneficial effects among PD patients.…”

Section: Omega-3 Polyunsaturated Fatty Acids (Pufas)mentioning

confidence: 99%

Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

Muralidhara¹,

Sv²,

SC³

2017

J Aging Sci

View full text Add to dashboard Cite

Various nutritional components belonging to different classes of natural dietary origin display modulatory (protective) properties against age-related neurodegenerative disorders (NDD) such as Parkinson's disease (PD) and Alzheimer's disease. These compounds termed as nutraceuticals which have been shown to act at various biochemical and metabolic levels and exhibit different degree of neuroprotective properties. Present review aims to summarize the current status on the modulatory impact of some of the major nutritional compounds on the pathophysiology of PD, the second most common NDD in humans. Primarily, we have examined the data demonstrated in animal models and postulated through epidemiological studies on the compounds/molecules/life style factors which reduce the risk associated with PD and probable mechanism/s through which they elicit neuroprotection. Further we also included some of the conflicting information about the compounds which may enhance the risk associated with PD. Additionally, emphasis is also given about the new approaches to understand the impact of nutrition on the epigenome in relation to the development of NDD with a short note on emerging ideas relating to nutritional genomics.

show abstract

Depression in Parkinson's disease: A double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation

Cited by 168 publications

References 42 publications

Neuropsychiatry of Parkinson's disease

Neuropsychiatry of Parkinson's disease

Review on Therapeutic Effects Mediated by Omega-3 Fatty Acids in Alzheimer’s Disease

Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

Contact Info

Product

Resources

About