Depression in Autoimmune Diseases

Pryce, Christopher R.; Fontana, Adriano

doi:10.1007/7854_2016_7

Cited by 68 publications

(58 citation statements)

References 71 publications

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“…Patients with autoimmune diseases tend to have a more frequent prevalence of behavioral problems . There is evidence that there is a high prevalence of depression and fatigue (17–80%) among people with SLE and that these have a substantial effect on quality of life .…”

Section: Discussionmentioning

confidence: 99%

Differences in quality of life determinants according to the presence of fibromyalgia in middle‐aged female patients with systemic lupus erythematosus: a multicenter, cross‐sectional, single‐ethnicity cohort

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Differences in quality of life determinants according to the presence of fibromyalgia in middle‐aged female patients with systemic lupus erythematosus: a multicenter, cross‐sectional, single‐ethnicity cohort

et al. 2018

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“…The findings that IP TNF induces sickness and reduces saccharin drinking add to the evidence that these two states co-occur. Previously, we have proposed that under these conditions reduced reward drinking is more parsimoniously referred to as extended sickness (Cathomas et al, 2015b;Pryce and Fontana, 2016). This is because immune-inflammatory challenges produce a different constellation of behavioral changes e.g.…”

Section: Integration and Implicationsmentioning

confidence: 99%

Differential effects of peripheral and brain tumor necrosis factor on inflammation, sickness, emotional behavior and memory in mice

Klaus

Paterna

Marzorati

et al. 2016

Brain, Behavior, and Immunity

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Tumor necrosis factor alpha (TNF) is increased in depression and clinical-trial evidence indicates that blocking peripheral TNF has some antidepressant efficacy. In rodents, peripheral or intracerebroventricular TNF results in sickness e.g. reduced body weight, altered emotional behavior and impaired memory. However, the underlying pathways and responsible brain regions are poorly understood. The aim of this mouse study was to increase understanding by comparing the effects of sustained increases in TNF in the circulation, in brain regions impacted by increased circulating TNF, or specific brain regions. Increased peripheral TNF achieved by repeated daily injection (IP-TNF) or osmotic pump resulted in decreased body weight, decreased saccharin (reward) consumption, and increased memory of an aversive conditioned stimulus. These effects co-occurred with increased plasma interleukin-6 and increased IPderived TNF in brain peri-ventricular regions. An adenovirus-associated viral TNF vector (AAV-TNF) was constructed, brain injection of which resulted in dose-dependent, sustained and region-specific TNF expression, and was without effect on blood cytokine levels. Lateral ventricle AAV-TNF yielded increased TNF in the same brain regions as IP-TNF. In contrast to IP-TNF it was without effect on body weight, saccharin consumption and fear memory, although it did increase anxiety. Hippocampal AAV-TNF led to decreased body weight. It increased conditioning to but not subsequent memory of an aversive context, suggesting impaired consolidation; it also increased anxiety. Amygdala AAV-TNF was without effect on body weight and aversive stimulus learning-memory, but reduced saccharin consumption and increased anxiety. This study adds significantly to the evidence that both peripheral and brain region-specific increases in TNF lead to both sickness and depression-and anxiety disorder-relevant behavior and do so via different pathways. It thereby highlights the complexity in terms of indirect and direct pathways via which increased TNF can act and which need to be taken into account when considering it as a therapeutic target. AbstractTumor necrosis factor alpha (TNF) is increased in depression and clinical-trial evidence indicates that blocking peripheral TNF has some antidepressant efficacy. In rodents, peripheral or intracerebroventricular TNF results in sickness e.g. reduced body weight, altered emotional behavior and impaired memory. However, the underlying pathways and responsible brain regions are poorly understood. The aim of this mouse study was to increase understanding by comparing the effects of sustained increases in TNF in the circulation, in brain regions impacted by increased circulating TNF, or specific brain regions.Increased peripheral TNF achieved by repeated daily injection (IP-TNF) or osmotic pump resulted in decreased body weight, decreased saccharin (reward) consumption, and increased memory of an aversive conditioned. These effects co-occurred with increased plasma interleukin-6 and increased I...

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“…The other studies reported similar frequency of fatigue in systemic autoimmune diseases that ranged from 70% in Sjögren's syndrome to 80% in systemic sclerosis and RA. The cause of fatigue in SAD is still unclear and some studies explain it by peripheral immune activation and systemic inflammation either directly or indirectly by mitochondrial damage induction [9,10]. Similarly, to some other studies, the lung function test abnormalities were found predominantly in patients with CVD [11].…”

Section: Clinical Featuresmentioning

confidence: 86%

Pleuropulmonary manifestations of systemic autoimmune diseases: An 84-case series analysis

et al. 2020

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Introduction/Objective. The systemic autoimmune diseases (SAD) can cause a variety of pulmonary and pleural abnormalities. The aim of this paper is to review clinical and radiological characteristics of a series of patients with systemic autoimmune disease hospitalized at a tertiary level facility. Methods. In this retrospective study, we reviewed the clinical and imaging findings in patients diagnosed with SAD at the Teaching Hospital of Pulmonology during a nine-year period. Results. The 84 patients group (mean age of 53.8 years) consisted of 64 women and 20 men. Fifty-eight out of 84 patients suffered from collagen vascular disease (CVD) and 26/84 had systemic vasculitis. Fatigue was a dominant symptom (75.8% in CVD, and 69.2% in vasculitis). Cough, hemoptysis, and fever were more frequent in patients with vasculitis. Fibrosis was the most common radiological manifestation of CVD (26/58), followed by pleural effusion (18/58) and consolidation (10/58). Irregular opacities were dominant radiologic finding in vasculitis (10/26), followed by nodules (8/26). Histological confirmation of systemic autoimmune disease was obtained in 28.6% patients, in 58/84 patients the diagnosis was based on positive serologic test and clinico-radiological manifestations, in two cases, on clinical and radiological features according to defined criteria. Conclusion. Pleuropulmonary manifestations of systemic autoimmune diseases are usually expressed in the sixth decade of age, predominantly in women. Clinical findings and positive serologic tests suggest diagnosis of systemic autoimmune diseases. Fibrosis is the most common radiologic pattern found in almost a half of the patients with CVD and irregular opacities are most common findings in vasculitis. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 175046]

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Depression in Autoimmune Diseases

Cited by 68 publications

References 71 publications

Differences in quality of life determinants according to the presence of fibromyalgia in middle‐aged female patients with systemic lupus erythematosus: a multicenter, cross‐sectional, single‐ethnicity cohort

Differences in quality of life determinants according to the presence of fibromyalgia in middle‐aged female patients with systemic lupus erythematosus: a multicenter, cross‐sectional, single‐ethnicity cohort

Differential effects of peripheral and brain tumor necrosis factor on inflammation, sickness, emotional behavior and memory in mice

Pleuropulmonary manifestations of systemic autoimmune diseases: An 84-case series analysis

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