Depression Associated With Oral Choline

Tamminga, Carol A.; Smith, R. C.; Chang, Sun‐Yran; Haraszti, J.; Davis, John M.

doi:10.1016/s0140-6736(76)90562-6

Cited by 72 publications

(9 citation statements)

References 7 publications

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“…Acetylcholine precursors, such as deanol, choline, and lecithin, have also been reported to cause depression, and paradoxically hypomania in some cases. Tamminga et al (1976) reported that choline precipitated depression in 2 out of 4 patients with tardive dyskinesia 32 , and Growdon et al (1977) reported that 2 out of 20 patients with tardive dyskinesia became withdrawn and apathetic 33 . Casey (1979) reported that high doses of deanol caused severe depression in 5 out of 33 movement disorder patients, and 3 of the 33 became hypomanic 34 .…”

Section: Cholinergic Regulation Of Mood Acetylcholinesterase Inhibitomentioning

confidence: 99%

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics

2018

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Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have been postulated. Over 50 years ago, clinical studies suggested that increases in central acetylcholine could lead to depressed mood. Evidence has continued to accumulate suggesting that the cholinergic system has a important role in mood regulation. In particular, the finding that the antimuscarinic agent, scopolamine, exerts fast-onset and sustained antidepressant effects in depressed humans has led to a renewal of interest in the cholinergic system as an important player in the neurochemistry of major depression and bipolar disorder. Here, we synthesize current knowledge regarding the modulation of mood by the central cholinergic system, drawing upon studies from human postmortem brain, neuroimaging, and drug challenge investigations, as well as animal model studies. First, we describe an illustrative series of early discoveries which suggest a role for acetylcholine in the pathophysiology of mood disorders. Then, we discuss more recent studies conducted in humans and/or animals which have identified roles for both acetylcholinergic muscarinic and nicotinic receptors in different mood states, and as targets for novel therapies.

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Section: Cholinergic Regulation Of Mood Acetylcholinesterase Inhibitomentioning

confidence: 99%

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics

2018

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“…However, no attempts have been made to test this hypothesis. In a case report of 2 patients with tardive dyskinesia, large doses of choline induced depressive symptoms in both patients (7). In an openlabel clinical trial, patients (n = 13) with Alzheimer disease showed no significant change in the mean Geriatric Depression Scale score after treatment with tetrahydroaminoacridine (an acetylcholine-esterase inhibitor) and lecithin (phosphatidylcholine) for 10 wk (8).…”

Section: Introductionmentioning

confidence: 99%

Choline in anxiety and depression: the Hordaland Health Study

Bjelland

Tell

Vollset

et al. 2009

The American Journal of Clinical Nutrition

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“…Only one pub lished study [1] has utilized DSM criteria for Organic Mood Syndrome or Substance-Induced Mood Disorder. [ 136] Carbamazepinc [ 137] Carbaryl [138] Choline [139] 13-m-retinoic acid therapy [140] Etretinate [141] Fluorouracil [142] Mefloquine [143,144] Metoclopramide [145,146] Metronidazole [147,148] Interferon-alpha [149][150][151][152] Isotretinoin [153][154][155] Lomefloxacin [ 156] Nonsteroidal anti-inflammatory medications [157,158] Ondansetron [ 159] Phenytoin [160] Physostigminc [161] Sumatriptan [162] Theophylline [163] Tretinoin [164] Vigabatrin [165] The avoidance of DSM diagnostic criteria by researchers may relate to the unusual nature of these specific sets of criteria, which depart from the DSM theme of nonre liance on clinical etiological judgements [2], The DSM-IV diagnostic criteria for Substance-Induced Mood Disorder rely heavily on clinical judgements about etiology.…”

Section: Introductionmentioning

confidence: 99%

Drug-Induced Depression

Patten

Love

1997

Psychother Psychosom

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Background: Certain drugs may contribute to the etiology of depressive symptoms and depressive disorders. The objective of this review is to critically appraise the literature concerned with these potential etiological associations. Method: The review was based on papers uncovered in electronic literature searches using Medline, Psychlit and Psychological Abstracts. Statistical power calculations were used to assist in the interpretation of negative results. Results: A large number of publications were uncovered, but most of these were case reports. There were relatively few empirical studies. Corticosteroids, certain calcium channel blockers and digoxin have been associated with depression by replicated, well conducted studies. Psychostimulant withdrawal is also associated with prominent depressive symptoms. Preliminary evidence suggests that antihyperlipidemic agents, angiotensin converting enzyme inhibitors, sedative hypnotics, psychostimulants and certain hormonal agents may also cause depression. Despite an extensive literature, the potential association between β-blockers and depressive symptoms remains controversial. There is no substantial evidence that l-dopa or histamine-2-receptor blockers cause depression and the literature is relatively conclusive in determining that thiazide diuretics are not associated with depressive symptoms. Conclusions: A small, but growing, literature confirms that certain drug exposures can contribute to the biopsychosocial etiology of depressive symptoms and disorders. Current beliefs and diagnostic conventions classify drug-induced depression into a distinct category (Substance-Induced Mood Disorder): but this approach is not specifically supported by the existing literature.

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Depression Associated With Oral Choline

Cited by 72 publications

References 7 publications

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics

Choline in anxiety and depression: the Hordaland Health Study

Drug-Induced Depression

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