Depression as a Risk Factor for Dementia and Alzheimer’s Disease

Cantón-Habas, Vanesa; Rich-Ruiz, Manuel; Romero-Saldaña, Manuel; Carrera-González, María Pilar

doi:10.3390/biomedicines8110457

Cited by 58 publications

(55 citation statements)

References 80 publications

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“…Serum plasma profiles may serve as a potential predictive biomarker for the choice of antidepressants [ 123 ]. Foods, or fortified food products beneficial to physiological body functions, were proposed for the treatment of metabolic dysfunction in ageing neurodegenerative diseases [ 124 ]. In addition to biomolecules, any measurable indicators are important for risk, diagnosis, prognostic, and predictive biomarkers and interventional targets.…”

Section: Neurological Sciences’ Approach To Mood and Anxiety Disordersmentioning

confidence: 99%

Crosstalk between Existential Phenomenological Psychotherapy and Neurological Sciences in Mood and Anxiety Disorders

et al. 2021

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Psychotherapy is a comprehensive biological treatment modifying complex underlying cognitive, emotional, behavioral, and regulatory responses in the brain, leading patients with mental illness to a new interpretation of the sense of self and others. Psychotherapy is an art of science integrated with psychology and/or philosophy. Neurological sciences study the neurological basis of cognition, memory, and behavior as well as the impact of neurological damage and disease on these functions, and their treatment. Both psychotherapy and neurological sciences deal with the brain; nevertheless, they continue to stay polarized. Existential phenomenological psychotherapy (EPP) has been in the forefront of meaning-centered counseling for almost a century. The phenomenological approach in psychotherapy originated in the works of Martin Heidegger, Ludwig Binswanger, Medard Boss, and Viktor Frankl, and it has been committed to accounting for the existential possibilities and limitations of one’s life. EPP provides philosophically rich interpretations and empowers counseling techniques to assist mentally suffering individuals by finding meaning and purpose to life. The approach has proven to be effective in treating mood and anxiety disorders. This narrative review article demonstrates the development of EPP, the therapeutic methodology, evidence-based accounts of its curative techniques, current understanding of mood and anxiety disorders in neurological sciences, and a possible converging path to translate and integrate meaning-centered psychotherapy and neuroscience, concluding that the EPP may potentially play a synergistic role with the currently prevailing medication-based approaches for the treatment of mood and anxiety disorders.

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Section: Neurological Sciences’ Approach To Mood and Anxiety Disordersmentioning

confidence: 99%

Crosstalk between Existential Phenomenological Psychotherapy and Neurological Sciences in Mood and Anxiety Disorders

et al. 2021

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“…Several studies have recently shown a strong association between metabolic disturbances and the development of anxiety-related disorders and poor cognitive outcomes (Avinun and Hariri, 2019;Ronan et al, 2019;van Duinkerken and Ryan, 2019), with higher rates of anxiety and depression found in overweight and obese people (Luppino et al, 2010;Gomes et al, 2019;James et al, 2020). Interestingly, both anxiety and depression are associated with an increased likelihood of developing AD (Becker et al, 2018;Canton-Habas et al, 2020).…”

Section: Neurological Consequences Of Obesity-related Derangements: Metabolic Risk Factors For Alzheimer's Diseasementioning

confidence: 99%

Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer’s Disease

et al. 2021

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Overnutrition and modern diets containing high proportions of saturated fat are among the major factors contributing to a low-grade state of inflammation, hyperglycemia and dyslipidemia. In the last decades, the global rise of type 2 diabetes and obesity prevalence has elicited a great interest in understanding how changes in metabolic function lead to an increased risk for premature brain aging and the development of neurodegenerative disorders such as Alzheimer’s disease (AD). Cognitive impairment and decreased neurogenic capacity could be a consequence of metabolic disturbances. In these scenarios, the interplay between inflammation and insulin resistance could represent a potential therapeutic target to prevent or ameliorate neurodegeneration and cognitive impairment. The present review aims to provide an update on the impact of metabolic stress pathways on AD with a focus on inflammation and insulin resistance as risk factors and therapeutic targets.

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“…The serum plasma profiles may serve as a potential predictive biomarker for the choice of antidepressants [118]. A food or fortified food product beneficial to physiological body functions, were proposed for the treatment of metabolic dysfunction in ageing neurodegenerative diseases [119]. In addition to biomolecules, any measurable indicators are entitled for risk, diagnosis, prognostic, and predictive biomarkers and interventional targets.…”

Section: Other Relevant Biomarkers and Therapeutic Targetsmentioning

confidence: 99%

Crosstalk between Existential Phenomenological Psychotherapy and Neurological Science in Mood and Anxiety Disorders

Balogh¹,

Tanaka²,

Török³

et al. 2021

Preprint

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Psychotherapy is a comprehensive biological treatment modifying complex underlying cognitive, emotional, behavioral, and regulatory responses in the brain, leading patients with mental illness to a new interpretation of the sense of self and others. Psychotherapy is an art of science integrated with psychology and/or philosophy. Neurological science studies the neurological basis of cognition, memory, and behavior as well as the impact of neurological damage and disease on the functions, and their treatment. Both psychotherapy and neurological science deal with the brain; nevertheless, they continue to stay polarized far. Existential phenomenological psychotherapy (EPP) has been in the forefront of meaning-centered counseling for almost a century. The phenomenological approach in psychotherapy originated in the works of Martin Heidegger, Ludwig Binswanger, Medard Boss and Viktor Frankl, and it has been committed to account for the existential possibilities and limitations of one’s life. EPP provides philosophically rich interpretations and empowers counseling techniques to assist mentally suffering individuals by finding meaning and purpose of life. The approach has proven to be effective in treating mood and anxiety disorders. This narrative review article demonstrates the development of EPP, the therapeutic methodology, evidence-based accounts of its curative techniques, current understanding of mood and anxiety disorders in neurological science, and a possible converging path to translate and integrate meaning-centered psychotherapy and neurological science, concluding that the existential phenomenological psychotherapy potently plays a synergistic role with the currently prevailing medication-based approaches for the treatment of mood and anxiety disorders.

show abstract

Depression as a Risk Factor for Dementia and Alzheimer’s Disease

Cited by 58 publications

References 80 publications

Crosstalk between Existential Phenomenological Psychotherapy and Neurological Sciences in Mood and Anxiety Disorders

Crosstalk between Existential Phenomenological Psychotherapy and Neurological Sciences in Mood and Anxiety Disorders

Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer’s Disease

Crosstalk between Existential Phenomenological Psychotherapy and Neurological Science in Mood and Anxiety Disorders

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