Depression, anxiety and health‐related quality of life amongst patients who are starting dialysis treatment

Abstract

S U M M A R YBackground: Chronic kidney disease (CKD) has a severe impact on patients' health-related quality of life (HRQL). The start of renal replacement therapy (RRT) significantly influences psychological, physical and social aspects of life. Objectives: To analyse the HRQL and psychological status (anxiety and depression) at the start of RRT. Methods: We undertook an observational descriptive cross-sectional study. A total of 152 patients starting RRT were recruited for the study. HRQL was measured by the Kidney Disease and Quality of Life Short Form questionnaire. Levels of anxiety and depression were assessed by the Hospital Anxiety and Depression Scale questionnaire. Comorbidities and sociodemographic and clinical factors were also evaluated. Findings: HRQL in patients with end-stage kidney disease (ESKD) is significantly affected by the initiation of RRT in all respects. States of anxiety and depression were present in 26.6% and 27% of patients, respectively. These states are significantly related to the emotional component of the quality of life. Conclusion: The initiation of RRT has a strong impact on HRQL in comparison with a reference population and with other stages of CKD. The early detection of an altered psychological state is important, as this condition should be treated from the first stages of the disease, as it can significantly affect the subsequent development of RRT and the patient's quality of life.

The impact of chronic kidney disease on developed countries from a health economics perspective: A systematic scoping review

“…Peritoneal dialysis was associated with better scores than HD for both generic and kidney specific domains [84,85]. Nagaraja et al [44], on the other hand, reported that mean SF-6D utility scores among patients managed by PD were similar to those receiving HD (0.53 ± 0.10 vs 0.52 ± 0.11, respectively).…”

Dialysis Start Timing: Development and Validation of Start Scoring Scale

“…Сроки начала диализа в мировой практике крайне вариабельны, что связано с рядом факторов, которые могут играть роль при принятии решения [3]. С од-ной стороны, слишком раннее начало ГД, раньше реальной потребности в нем, является трудным и затратным как для самого пациента, так и для систе-мы здравоохранения в целом [10,11]. С другой сто-роны, слишком долгое откладывание начала диализа приводит к увеличению длительности воздействия уремической интоксикации на системы и органы па-циента с соответствующим нежелательным ростом рисков летальности и прогрессирования коморбид-ности.…”

Contribution of monoamine oxidases to vascular oxidative stress in patients with end-stage renal disease requiring hemodialysis

“…Nowadays, several reversible MAOI are available in clinical practice for the treatment of neurodegenerative disorders and depression which renders them candidates for drug repurposing in pathologies associated with increased oxidative stress and cardiovascular mortality. Of note, these drugs are devoid of the irreversible MAOI sideeffects (in particular, the feared 'cheese effect') and might be used in patients with ESRD requiring hemodialysis where anxiety and depression are already present from the beginning of the therapy (Rebollo Rubio et al 2017).…”