Depression, anxiety, and cognitive functioning after intracerebral hemorrhage

Koivunen, Riitta; Harno, Hanna; Tatlısumak, Turgut; Putaala, Jukka

doi:10.1111/ane.12367

Cited by 62 publications

(58 citation statements)

References 44 publications

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“…These data are in agreement with previously reported findings that post-stroke fatigue and pain are closely related 2 and often coexist. 25,26 Although the cause and effect relationship between pain and fatigue remains unclear, this relationship may be bilateral;…”

Section: Discussionmentioning

confidence: 99%

Musculoskeletal and central pain at 1 year post-stroke: associated factors and impact on quality of life

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Musculoskeletal and central pain at 1 year post-stroke: associated factors and impact on quality of life

et al. 2016

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“…The incidence of PSA increases toward the chronic stage of stroke, with 31%–38% prevalence rates of anxiety during the 10 years following a stroke 4. PSA persists in a high proportion of cases, and it may play a greater role in young intracerebral hemorrhage (ICH) patients 7. Anxiety is also reported more frequently than depression symptoms for poststroke patients during the chronic stage (>1 year after the event) 8.…”

Section: Introductionmentioning

confidence: 99%

Effect of Yi-nao-jie-yu decoction on γ-aminobutyric acid type A receptor in the hippocampus and serum inflammatory factors in a rat model of poststroke anxiety

Zhang

Zhao

et al. 2016

NDT

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BackgroundThe Yi-nao-jie-yu decoction (YNJYD) is a herbal preparation widely used in the clinics of traditional Chinese medicine and has been recently used as an important new therapeutic agent in poststroke anxiety (PSA). The neuroendocrine–immune system plays an important role in PSA mechanisms, although the modulating effects of YNJYD remain unknown. This study investigated the potential effects of YNJYD on the neuroendocrine–immune system in a rat model of PSA.Materials and methodsThe PSA model was induced by injecting collagenase (type VII) into the right globus pallidus, accompanied by empty water bottle stimulation for 2 weeks. The sham group and the PSA model group were gavaged with saline, while the treatment groups received buspirone (BuSpar) or YNJYD. Behavior was evaluated with the open field test and elevated plus maze once a week. Pathological changes were observed by hematoxylin and eosin staining. Serum levels of tumor necrosis factor, interleukin (IL)-6, adrenocorticotropic hormone, thyroid stimulating hormone, free triiodothyronine, free thyroxine, IL-1α, and cortisol were detected by radioimmunoassay. Expression of the γ-aminobutyric acid type A receptor (GABAAR) α2 subunit was examined by Western blot and real-time polymerase chain reaction.ResultsYNJYD-treated rats exhibited significantly better recovery than BuSpar-treated rats at 21 days and 28 days in the open field test and elevated plus maze. Hematoxylin and eosin staining revealed neural repair in the hippocampus in the treatment groups. Serum levels of IL-1α in the YNJYD group were significantly less than those in the model group and the BuSpar group. GABAAR protein and mRNA expressions were higher in the PSA model group than in the sham group, and YNJYD reversed these effects.ConclusionYNJYD alleviated the symptoms of PSA mainly by decreasing IL-1α levels and downregulating GABAAR expression in the hippocampus to maintain a neuroendocrine–mmune system balance.

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“…1,4–6 Physical difficulties are the primary concern and focus for treatments but it is common for this population to experience neuropsychiatric complications (ie, emotion, behavioral, and cognitive disorders). 7 These complications have been shown to have a negative effect on motor functioning, social functioning, and overall quality of life. 7–10 Of the many psychiatric complications, depression is one of the most frequently reported.…”

mentioning

confidence: 99%

“…7 These complications have been shown to have a negative effect on motor functioning, social functioning, and overall quality of life. 7–10 Of the many psychiatric complications, depression is one of the most frequently reported. 11 …”

mentioning

confidence: 99%

Lower Odds of Poststroke Symptoms of Depression When Physical Activity Guidelines Met: National Health and Nutrition Examination Survey 2011–2012

Aaron

Gregory²,

Simpson³

2016

Journal of Physical Activity and Health

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Background One-third of individuals with stroke report symptoms of depression, which has a negative impact on recovery. Physical activity (PA) is a potentially effective therapy. Our objective was to examine the associations of subjectively assessed PA levels and symptoms of depression in a nationally representative stroke sample. Methods We conducted a cross-sectional study of 175 adults in the National Health and Nutrition Examination Survey 2011–2012 cycle. Moderate, vigorous, and combination equivalent PA metabolic equivalent (MET)-minutes per week averages were derived from the Global Physical Activity Questionnaire, and .the 2008 Physical Activity Guidelines/American College of Sports Medicine recommendations of ≥500 MET-minutes per week of moderate, vigorous, or combination equivalent PA were used as cut points. Depression symptoms were measured using the Patient Health Questionnaire-9. Results Meeting moderate PA guidelines resulted in 74% lower odds of having depression symptoms (P < .0001) and 89% lower odds of major symptoms of depression (P = .0003). Meeting vigorous guidelines showed a 91% lower odds of having mild symptoms of depression (P = .04). Participating in some moderate, vigorous, or combination equivalent PA revealed the odds of depression symptoms 13 times greater compared with meeting guidelines (P = .005); odds of mild symptoms of depression were 9 times greater (P = .01); and odds of major symptoms of depression were 15 times greater (P = .006). Conclusions There is a lower risk of developing mild symptoms of depression when vigorous guidelines for PA are met and developing major symptoms of depression when moderate guidelines met. Participating in some PA is not enough to reduce the risk of depression symptoms.

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Depression, anxiety, and cognitive functioning after intracerebral hemorrhage

Abstract: One of four survivors of ICH at young age suffers long-term PSD. Higher degree of disability predicted occurrence of PSD. Treatment of depression appears as an unmet need in young ICH survivors.

Cited by 62 publications

References 44 publications

Musculoskeletal and central pain at 1 year post-stroke: associated factors and impact on quality of life

Musculoskeletal and central pain at 1 year post-stroke: associated factors and impact on quality of life

Effect of Yi-nao-jie-yu decoction on γ-aminobutyric acid type A receptor in the hippocampus and serum inflammatory factors in a rat model of poststroke anxiety

Lower Odds of Poststroke Symptoms of Depression When Physical Activity Guidelines Met: National Health and Nutrition Examination Survey 2011–2012

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Depression, anxiety, and cognitive functioning after intracerebral hemorrhage

Abstract: One of four survivors of ICH at young age suffers long-term PSD. Higher degree of disability predicted occurrence of PSD. Treatment of depression appears as an unmet need in young ICH survivors.

Cited by 62 publications

References 44 publications

Musculoskeletal and central pain at 1 year post-stroke: associated factors and impact on quality of life

Musculoskeletal and central pain at 1 year post-stroke: associated factors and impact on quality of life

Effect of Yi-nao-jie-yu decoction on &gamma;-aminobutyric acid type A receptor in the hippocampus and serum inflammatory factors in a rat model of poststroke anxiety

Lower Odds of Poststroke Symptoms of Depression When Physical Activity Guidelines Met: National Health and Nutrition Examination Survey 2011–2012

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Effect of Yi-nao-jie-yu decoction on γ-aminobutyric acid type A receptor in the hippocampus and serum inflammatory factors in a rat model of poststroke anxiety