Depression and the risk of vascular dementia: a population‐based retrospective cohort study

Lin, Wei Chen; Hu, Li; Tsai, Shih Jen; Yang, Albert C.; Shen, Cheng Che

doi:10.1002/gps.4493

Cited by 22 publications

(17 citation statements)

References 42 publications

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“…Nine prospective studies ( n = 376–49,955) with follow-up from 2.4 to 25.5 years addressed the association between CAD and risk of MCI/dementia 11 – 13 , 32 , 33 , 60 – 63 . Five studies showed that clinical CAD significantly increased the risk of dementia, with HRs of 2.1–2.9 13 , 32 , 33 , 60 , 63 ) . In the Rotterdam study, unrecognized MI determined by electrocardiography was not related to dementia overall; however, there was a positive association in men (HR 2.23, 95%CI 1.24–4.01) 62 ) .…”

Section: Resultsmentioning

confidence: 99%

“…One study investigated the association of midlife CAD (diagnosed at or before baseline examination) and late-life CAD (diagnosed at or before first re-examination) with dementia and found that midlife CAD was not associated with dementia, whereas participants with late-life CAD tended to have a higher risk of dementia (HR 1.66, 95%CI 0.81–3.16) 11 ) . Meta-analysis was conducted in studies that reported HRs 11 – 13 , 61 – 63 ) and studies that reported ORs 32 , 33 , 60 ) separately. Pooled HR and pooled OR of CAD for MCI/dementia were 1.51 (95%CI 1.24–1.85, I 2 = 14.1%, p = 0.32) and 2.65 (95%CI 1.62–4.33, I 2 = 0.0%, p = 0.96), respectively ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, there was diversity in assessment of cognitive function and there may have been differences in percentage of dementia subtypes. Most studies used the Diagnostic and Statistical Manual of Mental Disorders for diagnosis of dementia without specifying subtypes; only a few studies clearly differentiated dementia subtypes 25 , 30 , 61 , 63 ) . Also, differences in duration of the follow-up period may play a role.…”

Section: Discussionmentioning

confidence: 99%

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The Relationship of Coronary Artery Calcium and Clinical Coronary Artery Disease with Cognitive Function: A Systematic Review and Meta-Analysis

Xia

Vonder

Sidorenkov

et al. 2020

JAT

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Aim: Coronary artery disease (CAD) and cognitive impairment are common in the elderly, with evidence for shared risk factors and pathophysiological processes. The coronary artery calcium (CAC) score is a marker of subclinical CAD, which may allow early detection of individuals prone to cognitive decline. Prior studies on associations of CAC and clinical CAD with cognitive impairment had discrepant results. This systematic review aims to evaluate the association of (sub)clinical CAD with cognitive function, cognitive decline, and diagnosis of mild cognitive impairment (MCI) or dementia. Methods: A systematic search was conducted in MEDLINE, Embase, and Web of Science until February 2019, supplemented with citations tracking. Two reviewers independently screened studies and extracted information including odds ratios (ORs) and hazard ratios (HRs).Results: Forty-six studies, 10 on CAC and 36 on clinical CAD, comprising 1,248,908 participants were included in the systematic review. Studies about associations of (sub)clinical CAD with cognitive function and cognitive decline had heterogeneous methodology and inconsistent findings. Two population-based studies investigated the association between CAC and risk of dementia over 6-12.2 years using different CAC scoring methods. Both found a tendency toward higher risk of dementia as CAC severity increased. Meta-analysis in 15 studies (663,250 individuals) showed an association between CAD and MCI/dementia (pooled OR 1.32, 95%CI 1.17-1.48) with substantial heterogeneity (I 2 87.0%, p 0.001). Pooled HR of CAD for incident MCI/dementia over 3.2-25.5 years in six longitudinal studies (70,060 individuals) was 1.51 (95%CI 1.24-1.85), with low heterogeneity (I 2 14.1%, p 0.32). Sensitivity analysis did not detect any study that was of particular influence on the pooled OR or HR. Conclusions:Limited evidence suggests the CAC score is associated with risk of dementia. In clinical CAD, risk of MCI and dementia is increased by 50%, as supported by stronger evidence.of CAD has declined during the past decades because of improvement in disease management, resulting in an increasing number of CAD patients with a higher life expectancy 1) . These patients, although they survive CAD, may develop other age-related diseases such as dementia in their late life. Mild cognitive impairment

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Relationship of Coronary Artery Calcium and Clinical Coronary Artery Disease with Cognitive Function: A Systematic Review and Meta-Analysis

Xia

Vonder

Sidorenkov

et al. 2020

JAT

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“…Based on previous studies, we selected age, [25][26][27][28][29] sex, 30 income level, 31 comorbidity, 32 presence of disability 33 and region 31 as covariates affecting the incidence of dementia. The specific definitions of the variables were determined as follows: through a review of previous studies, [25][26][27][28][29] the association between depression and dementia appeared clinically in three age groups, and age was therefore categorised into three groups (≤44 years, 45-64 years and ≥65 years).…”

Section: Other Variablesmentioning

confidence: 99%

Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort database

Jung

et al. 2020

BMJ Open

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ObjectivesDementia is common in people over the age of 65 years, with 80% of people with dementia older than 75 years. Previous studies have linked dementia to late-life depression, but the association between dementia and mid-life depression is poorly understood. Depression is a preventable and treatable medical condition, which means it is a modifiable factor that can potentially prevent or delay dementia. This study aimed to identify the association between dementia and depression within the life course.DesignA nationwide, retrospective propensity score matched cohort study associating dementia with depression. Depression diagnosed between the ages of 45 and 64 years was classified as ‘mid-life’ and ‘late-life’ if diagnosed at 65 years or older. Patients were considered to have depression when one or more International Statistical Classification of Diseases and Related Health Problems, 10th revision codes for depression were recorded as primary or secondary diagnosis.SettingNational Health Insurance Service-National Sample Cohort database of the National Health Insurance Service in South Korea, containing patient data from 2002 to 2013.ParticipantsThe study included 1824 and 374 852 patients in the case and control groups, respectively. A logistic regression analysis with complex sampling design was performed after adjusting for covariates, using the propensity score matching method without callipers, with a 1:1 nearest neighbour matching algorithm.Primary and secondary outcome measuresThe association of mid-onset and late-onset depression with dementia in terms of sociodemographic characteristics, such as sex and age, within the Korean population.ResultsDementia was significantly associated with the presence of depression (OR=2.20, 95% CI=1.53–3.14); in particular, female patients with depression and patients aged 45–64 years with depression had increased odds of dementia (OR=2.65, 95% CI=1.78–3.93 and OR=2.72, 95% CI=1.41–5.24, respectively)ConclusionDepression is an associated factor for dementia, especially among people aged 45–64 years (mid-life).

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“…Взаимосвязь между депрессией позднего возраста и риском деменции особенно актуальна среди пожилых людей с УКН, поскольку сочетание у больного этих состояний приводит к повышению риска деменции примерно на 30% по сравнению с больными с УКН без депрессии [45]. Другие исследования также показали, что депрессия является независимым ФР для последующего развития сосудистой деменции [46]. В исследовании H. Lenoir и соавт.…”

Section: л е к ц и и к л и н и ч е с к и е п р и з н а к и с о с у д unclassified

Vascular depression and cognitive dysfunction

Боголепова

2019

RJTAO

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Vascular depression is a very frequent and serious complication of cerebrovascular diseases. Vascular factors play an important role in the development of affective disorders. Depression, in turn, also has a negative impact on the course of cardiovascular disease, contributing to its progression, worsens quality of life in patients, reduces functional activity, increases mortality, and increases the risk of stroke. The diagnosis of vascular depression is confirmed by MRI detection of leukoaraiosis; in this case, deep white matter hyperintensities are of importance. The very important features of vascular depression are the presence of CI and an increased risk of dementia.

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Depression and the risk of vascular dementia: a population‐based retrospective cohort study

Abstract: Our findings suggest that depression is an independent risk factor for subsequent VaD. Older age, cerebrovascular disease, head injury, and coronary artery disease might increase the risk of VaD among patients with depression.

Cited by 22 publications

References 42 publications

The Relationship of Coronary Artery Calcium and Clinical Coronary Artery Disease with Cognitive Function: A Systematic Review and Meta-Analysis

The Relationship of Coronary Artery Calcium and Clinical Coronary Artery Disease with Cognitive Function: A Systematic Review and Meta-Analysis

Association between dementia and depression: a retrospective study using the Korean National Health Insurance Service-National Sample Cohort database

Vascular depression and cognitive dysfunction

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