Depression and Stages of Huntington’s Disease

Paulsen, Jane S.; Nehl, Carissa; Hoth, Karin F.; Kanz, Jason E.; Benjamin, Michelle; Conybeare, Rachel A; McDowell, Bradley D.; Turner, Beth M.

doi:10.1176/jnp.17.4.496

Cited by 211 publications

(80 citation statements)

References 40 publications

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“…From the HD literature that has addressed disease stage, there are mixed results regarding critical periods for anxiety and depression, but suggest they do not necessarily follow a linear trend across disease stage[9, [12][13][14]. One large study revealed a significant peak in anxiety and depression symptoms at Stage 2 of the disease, while the authors of a more recent study found prevalence of moderate to severe depression to be highest among stages 4-5[9].…”

Section: Introductionmentioning

confidence: 99%

Disease stage, but not sex, predicts depression and psychological distress in Huntington's disease: A European population study

Dale

Maltby

Shimozaki

et al. 2016

Journal of Psychosomatic Research

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Section: Introductionmentioning

confidence: 99%

Disease stage, but not sex, predicts depression and psychological distress in Huntington's disease: A European population study

Dale

Maltby

Shimozaki

et al. 2016

Journal of Psychosomatic Research

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“…Clinical diagnosis of HD is determined on the basis of motor symptoms; however, the pre-motor stages of the disease are commonly associated with psychiatric manifestations including depression (Paulsen et al, 2005;Duff et al, 2007;Julien et al, 2007;Marshall et al, 2007). Depression is one of the most prevalent causes of disability worldwide and is diagnosed in women more frequently than in men (Fava and Kendler, 2000;Kornstein et al, 2000;Marcus et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Treatment of depressive‐like behaviour in Huntington's disease mice by chronic sertraline and exercise

Renoir

Pang

Zajac

et al. 2012

British J Pharmacology

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BACKGROUND AND PURPOSEDepression is the most common psychiatric disorder in Huntington's disease (HD) patients. Women are more prone to develop depression and such susceptibility might be related to 5-hydroxytryptaminergic (serotonergic) dysregulation. EXPERIMENTAL APPROACHWe performed tests of depression-related behaviours on female R6/1 HD mice that had been chronically treated with sertraline or provided with running-wheels. Functional assessments of 5-HT1A and 5-HT2A receptors were performed by measuring behavioural and physiological responses following administration of specific agonists, in combination with analysis of hippocampal gene expression. Finally we assessed the effect of exercise on hippocampal cell proliferation. KEY RESULTSFemale HD mice recorded increased immobility time in the forced-swimming test, reduced saccharin preference and a hyperthermic response to stress compared with wild-type animals. These alterations were improved by chronic sertraline treatment. Wheel-running also resulted in similar improvements with the exception of saccharin preference but failed to correct the hippocampal cell proliferation deficits displayed by HD mice. The benefits of sertraline treatment and exercise involved altered 5-HT1A autoreceptor function, as demonstrated by modulation of the exaggerated 8-OH-DPAT-induced hypothermia exhibited by female HD mice. On the other hand, sertraline treatment was unable to restore the reduced 5-HT1A and 5-HT2 heteroceptor function observed in HD animals. CONCLUSIONS AND IMPLICATIONSWe report for the first time a crucial role for 5-HT1A autoreceptor function in mediating the sex-specific depressive-like phenotype of female R6/1 HD mice. Our data further support a differential effect of chronic sertraline treatment and exercise on hippocampal cell proliferation despite common behavioural benefits.Abbreviations 5-CT, 5-carboxamidotryptamine; 5-HTT, 5-HT transporter; AUC, area under curve; BDNF, brain-derived neurotrophic factor; BrdU, 5-bromo-2′-deoxyuridine; FST, forced-swimming test; GR, glucocorticoid receptor; HD, Huntington's disease; HPA, hypothalamic-pituitary-adrenal; RW, running-wheel; SH, standard-housed; SSRIs, selective 5-HT re-uptake inhibitors; TST, tail-suspension test; WT, wild-type BJP British Journal of Pharmacology DOI:10.1111DOI:10. /j.1476DOI:10. -5381.2011 British Journal of Pharmacology (2012) IntroductionHuntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an abnormal expansion of CAG repeats in exon 1 of the huntingtin gene (The Huntington's Disease Collaborative Research Group, 1993). Clinical diagnosis of HD is determined on the basis of motor symptoms; however, the pre-motor stages of the disease are commonly associated with psychiatric manifestations including depression (Paulsen et al., 2005;Duff et al., 2007;Julien et al., 2007;Marshall et al., 2007). Depression is one of the most prevalent causes of disability worldwide and is diagnosed in women more frequently than in men (Fava and Kendler, 2000;Kornstein e...

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“…This data can be justified, according to literature, as a neuropsychiatric symptom unrelated to cognitive or motor deficits and may have as a predictor anxiety 16,[23][24][25] .…”

Section: Discussionmentioning

confidence: 86%

“…Anxiety was also one of the changes often mentioned by caregivers and is pointed as a major cause of problems in interpersonal relationships of individuals with HD and their caregivers 9,15,22,23 .…”

Section: Discussionmentioning

confidence: 99%

Comportamento, competência social e qualidade de vida na Doença de Huntington

2015

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RESUMO: Objetivo: investigar o comportamento, a competência social e a qualidade de vida de indivíduos com a Doença de Huntington (DH), segundo opinião de seus cuidadores. Métodos: constituíram a casuística 30 participantes, com faixa etária de 33 a 79 anos, subdivididos em dois grupos: 15 do grupo amostral (GA) diagnosticados previamente com Doença de Huntington e 15 participantes do grupo controle (GC), pareados quanto à faixa etária, gênero e classificação socioeconômica. Para avaliação destes sujeitos foram aplicados, em seus cuidadores, o Inventário Comportamental Adult Behavior Checklist e o Questionário de Qualidade de Vida WHOQOL-100. Resultados: na avaliação do comportamento e da competência social, os sujeitos do GA apresentaram diferença estatisticamente significante em relação ao GC, segundo opinião dos seus cuidadores, com escores elevados para fatores internalizantes (ansiedade, depressão, isolamento, queixas somáticas), totais de problemas e outros, como problemas do pensamento, atenção e hiperatividade. No questionário de qualidade de vida, para sujeitos com a DH também se evidenciou diferença estatisticamente significante em relação ao grupo controle, em todos os domínios (físico, psicológico, nível de independência, relações sociais, ambiente e aspectos religiosos) e na maioria dos subitens avaliados. O GA apresentou média baixa de qualidade de vida, enquanto o GC apresentou média alta. Conclusão: sujeitos com DH possuem um perfil comportamental, de competência social e qualidade de vida diferenciado e com mais alterações, em relação ao GC, segundo os cuidadores . A Doença de Huntington parece ser responsável pelo conjunto de alterações comportamentais, de competência social e de qualidade de vida, relatado pelos cuidadores.

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Depression and Stages of Huntington’s Disease

Cited by 211 publications

References 40 publications

Disease stage, but not sex, predicts depression and psychological distress in Huntington's disease: A European population study

Disease stage, but not sex, predicts depression and psychological distress in Huntington's disease: A European population study

Treatment of depressive‐like behaviour in Huntington's disease mice by chronic sertraline and exercise

Comportamento, competência social e qualidade de vida na Doença de Huntington

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