Depression and Quality of Life in Patients Living 10 to 18 Years Beyond Heart Transplantation

Fusar‐Poli, Paolo; Martinelli, Valentina; Klersy, Catherine; Campana, Carlo; Callegari, Aliria; Barale, Francesco; Viganò, Mario; Politi, Pierluigi

doi:10.1016/j.healun.2005.06.022

Cited by 52 publications

(41 citation statements)

References 44 publications

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“…The rates of depression seen in patients 5 years after transplantation were not dissimilar to those seen in more long-term studies, 16 although emotional role and social functioning appeared to have been better in our population at this earlier time-point. Some studies have suggested that depression may be one of the most important variables affecting overall HRQOL 5 and, although our study has suggested similar mental health scores among the general population in the UK, this may also be an area where focused medical management may improve the HRQOL in this patient cohort.…”

Section: Strengths and Weaknesses Of The Study And Comparisons With contrasting

confidence: 50%

Health-related Quality of Life After Cardiac Transplantation: Results of a UK National Survey With Norm-based Comparisons

Saeed¹,

Rogers²,

Murday³

2008

The Journal of Heart and Lung Transplantation

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Section: Strengths and Weaknesses Of The Study And Comparisons With contrasting

confidence: 50%

Health-related Quality of Life After Cardiac Transplantation: Results of a UK National Survey With Norm-based Comparisons

Saeed¹,

Rogers²,

Murday³

2008

The Journal of Heart and Lung Transplantation

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“…[5][6][7][8] Behavioral factors such as noncompliance with therapy and depression have also been related to acute rejections and poor prognosis post-HTx. 9 -11 Persistent symptoms of psychologic distress are prevalent among HTx patients 11,12 and have a negative impact on compliance. 13,14 Little evidence has been published to date, but there is some indication that these symptoms might also predict long-term mortality after HTx.…”

mentioning

confidence: 99%

“…21 Hence, our findings support the notion that psychologic factors require continuous attention in the longterm care of post-HTx patients. 11 Symptoms of psychologic distress are prevalent among HTx patients, 11,12 but recipients differ greatly in the extent to which they experience distress. 18 Individual difference variables such as Type D personality may help to predict the susceptibility for persistent symptoms of psychologic distress among patients who have undergone HTx.…”

mentioning

confidence: 99%

Unfavorable Outcome of Heart Transplantation in Recipients With Type D Personality

Denollet

Vrints

et al. 2007

The Journal of Heart and Lung Transplantation

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Unfavorable outcome of heart transplantation in recipients with type D personalityDenollet, Johan; Holmes, R.V.F.H.; Vrints, C.J.; Conraads, V. Published in:The Journal of Heart and Lung Transplantation Document version:Publisher's PDF, also known as Version of record General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.-Users may download and print one copy of any publication from the public portal for the purpose of private study or research -You may not further distribute the material or use it for any profit-making activity or commercial gain -You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright, please contact us providing details, and we will remove access to the work immediately and investigate your claim. Background: The role of personality in heart transplantation (HTx) remains largely unknown. We examined the distressed personality (Type D) as a predictor of outcomes in patients suffering from end-stage heart disease who underwent HTx. Methods:Using the DS14 scale, 51 patients (75% men; 54.1 Ϯ 9.7 years of age) were diagnosed as Type D or non-Type D in the pre-transplant period. End-points of this prospective follow-up study (mean 5.4 years) were mortality and allograft rejection (Grade Ն3A rejection, rejection-free days after HTx). Results:At baseline, 15 patients were diagnosed as Type D and 36 as non-Type D; they did not differ in recipient or donor characteristics. At follow-up, there were 8 deaths; the mortality rate of Type D recipients was 33% vs 8% for non-Type Ds ( p ϭ 0.036). Two deaths were due to early post-operative complications and were excluded from further analyses. Type D recipients had a 10-fold higher mortality rate after hospital discharge (5 of 15, or 33%) as compared with non-Type D recipients (1 of 34, or 3%) ( p ϭ 0.013, adjusting for age and gender). Among surviving recipients, the rate of Grade Ն3A rejection for both groups was 40% vs 27%, respectively (p ϭ 0.45). The first episode of rejection was diagnosed, on average, after 14 days in Type D recipients vs after 50 days in the other patients (p ϭ 0.032). The risk of unfavorable outcomes (death, Grade Ն3A rejection, or number rejection-free days Յ14) was greater in Type D recipients (12 of 15, or 80%) than in non-Type Ds (13 of 34, or 38%), adjusting for other risk factors (odds ratio: 6.75; 95% confidence interval: 1.47 to 30.97) ( p ϭ 0.014). Conclusions: Type D personality independently predicted mortality and early allograft rejection, and should be accounted for when planning interventions to achieve optimal outcomes after HTx. J Heart Lung Transplant 2007;26:152-8.

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“…[1][2][3] Depression is also a major risk factor for medication non-adherence, thereby resulting in poor posttransplant outcome. 2,3 The potential relevance of this issue was recently demonstrated by findings that showed about 22% to 32% of patients surviving more than 10 years after HTx had self-reported depressive symptoms.…”

mentioning

confidence: 99%

Getting Old With a New Heart: Impact of Age on Depression and Quality of Life in Long-term Heart Transplant Recipients

Martinelli

Fusar‐Poli

Emanuele

et al. 2007

The Journal of Heart and Lung Transplantation

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Depression and Quality of Life in Patients Living 10 to 18 Years Beyond Heart Transplantation

Cited by 52 publications

References 44 publications

Health-related Quality of Life After Cardiac Transplantation: Results of a UK National Survey With Norm-based Comparisons

Health-related Quality of Life After Cardiac Transplantation: Results of a UK National Survey With Norm-based Comparisons

Unfavorable Outcome of Heart Transplantation in Recipients With Type D Personality

Getting Old With a New Heart: Impact of Age on Depression and Quality of Life in Long-term Heart Transplant Recipients

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