Depression After Coronary Artery Disease Is Associated With Heart Failure

May, Heidi T.; Horne, Benjamin D.; Carlquist, John F.; Sheng, Xiaoming; Joy, Elizabeth A.; Catinella, A. Peter

doi:10.1016/j.jacc.2009.01.036

Cited by 61 publications

(50 citation statements)

References 42 publications

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“…These findings were in line with those studies that have shown that individuals who experience negative emotions, such as depression, were at an increased risk of CAD (12,25,26). In a cohort of 7,709 patients with confirmed CAD but without a diagnosis of heart failure or depression, a subsequent diagnosis of depression was associated with 50% increase in the risk of heart failure (14). The Nurses' Health Study analysis also suggested that antidepressant use tripled the risk of sudden cardiac death in healthy women (15).…”

Section: Discussionsupporting

confidence: 91%

“…Despite availability of strong evidence on the link between depression and outcomes among patients with heart disease, the effect of depression on cardiovascular disease in general population is still not clear (12). Some (13)(14)(15), but not all (14,16) studies have shown positive results. For instance, a prospective cohort of 136,293 community-dwelling postmenopausal women revealed that new antidepressant use was not significantly associated with increased incidence of CAD (16).…”

Section: Introductionmentioning

confidence: 99%

“…For instance, a prospective cohort of 136,293 community-dwelling postmenopausal women revealed that new antidepressant use was not significantly associated with increased incidence of CAD (16). Another study also failed to find an effect of antidepressant use on the risk of heart failure in patients with CAD (14). Barrick argued that it is premature to describe depression as a cause of ►Implication for health policy/practice/research/medical education:…”

Section: Introductionmentioning

confidence: 99%

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Baseline Depressive Symptoms Predict Subsequent Heart Disease; A 20-Year Cohort

Lankarani¹,

Assari²

2016

Int Cardiovasc Res J

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A B S T R A C TBackground: Depression is common among patients with heart disease. Depression is also associated with worse outcomes among patients with heart disease. Fewer studies have shown whether or not baseline depressive symptoms predict subsequent heart disease in general population. Objectives: This study aimed to investigate whether depressive symptoms at baseline predict risk of developing heart disease during the next 20 years in the United States. Patients and Methods:The data were extracted from the Health and Retirement Study (HRS), 1992 -2012. The study was conducted on 8,375 individuals who were older than 50 years at entry, did not have heart disease at baseline, and had data on heart disease over the next 20 years. High depressive symptoms (modified Center for Epidemiologic Studies Depression Scale [CES-D]) were considered as the independent variable. Self-reported data on physician diagnosis of heart disease were measured on a biannual basis. Baseline demographic data (i.e., age and gender), socioeconomic status (i.e., race, marital status, and education level), health behaviors (i.e., drinking, smoking, and exercise), and body mass index were controlled. Cox proportional hazard model was used for data analysis. Results: Cox proportional hazard model revealed a link between high depressive symptoms at baseline and time to developing heart disease (Hazard ratio = 1.439, 95% CI = 1.253 -1.652), suggesting that individuals with high depressive symptoms at baseline developed heart disease sooner than others. The association between baseline depressive symptoms and risk of heart disease was significant after controlling for all the covariates. Conclusions: Individuals with depressive symptomatology are at higher risk of development of heart disease over time. Thus, individuals with depressed mood may need more rigorous evaluation for heart disease.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Baseline Depressive Symptoms Predict Subsequent Heart Disease; A 20-Year Cohort

Lankarani¹,

Assari²

2016

Int Cardiovasc Res J

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“…Patients with post-MI depression have a 1.6-to 2.7-fold increased risk of new cardiac events, cardiac mortality, and all-cause mortality within 24 months. 7 They also have an increased rate of subsequent heart failure, 8 hospital readmissions, 9 and overall increased healthcare resource utilization. 9 There have been several biological mechanisms by which depression may be related to coronary artery disease.…”

Section: Epression Is Prevalent Among Patients With Coronarymentioning

confidence: 99%

Clinical Impact of Subsequent Depression in Patients With a New Diagnosis of Stable Angina

Szpakowski

Bennell

Qiu

et al. 2016

Circ: Cardiovascular Quality and Outcomes

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Background-Depression is prevalent among patients with myocardial infarction and is associated with a worse prognosis.However, little is known about its importance in patients with chronic stable angina. We conducted a retrospective population-based cohort study to determine the occurrence and predictors of developing depression in patients with a new diagnosis of chronic stable angina. In addition, we sought to understand its impact on subsequent clinical outcomes. Methods and Results-Our cohort included patients in Ontario, Canada, with stable angina based on obstructive coronary artery disease found on angiogram. Depression was ascertained by physician billing codes and hospital admissions diagnostic codes. We first developed multivariable Cox proportional hazards models to determine predictors of developing depression. Clinical outcomes of interest included all-cause mortality, admission for myocardial infarction, and subsequent revascularization. Using hierarchical multivariable Cox proportional hazards models with occurrence of depression as a time-varying variable to control for potential immortal time bias, we evaluated the impact of depression on clinical outcomes. Our cohort consisted of 22 917 patients. The occurrence of depression after diagnosis of stable chronic angina was 18.8% over a mean follow-up of 1084 days. Predictors of depression included remote history of depression, female sex, and more symptomatic angina based on Canadian Cardiovascular Society class. Patients who developed depression had a higher risk of death (hazard ratio 1.83, 95% confidence interval 1.62-2.07) and admission for myocardial infarction (hazard ratio 1.36, 95% confidence interval 1.10-1.67) compared with nondepressed patients. Conclusions-Depression is common in patients with chronic stable angina and is associated with increased morbidity and mortality. (Circ Cardiovasc Qual Outcomes. 2016;9:731-739.

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“…However, if any differences were found in recovery between the groups, the result would indicate new topics for further research. Health care professionals have recognized the necessity of interventions in general after MI [5,7] and for concentrating on anxiety and depression, which have strong negative effects on recovery after MI [8] .…”

mentioning

confidence: 99%

Supporting and inhibiting factors in recovery experienced by the patients after myocardial infarction during an 18-month follow-up

Oranta

Luutonen

Leino‐Kilpi

2012

JNEP

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Objective: There is a need for studies on recovery as experienced by the patient after myocardial infarction. This study is a report on supporting and inhibiting factors in recovery of Finnish patients after myocardial infarction in an Interpersonal Counselling intervention group and in a control group given standard care at 6 months and 18 months after myocardial infarction. Methods:Firstly, during the 6 months following patients receiving IPC (n=21) and standard care (n=19) kept diaries related to supporting and inhibiting factors in recovery. The data were analyzed by inductive content analysis. Secondly, the patients (44 in the intervention group and 42 in the control group) were interviewed with the same open-ended questions 18 months after myocardial infarction. This data were analyzed using deductive content analysis. An attribution analysis was performed on both data. Results:Five main categories, including supporting and inhibiting factors and subcategories, were identified: (1) clinical and physical, (2) psychological, (3) social, (4) functional and (5) professional. There were no differences between the groups. Conclusions:Recovery experienced by the patient after myocardial infarction seems to consist of many supporting and inhibiting factors. This is important to take into account in developing nursing practice. The topic calls for more specific studies. These results could be useful material in developing and testing a quantitative instrument for more precise measuring of recovery after MI in a randomized setting. To develop theory, the results indicate numerous possibilities to test relationships between supporting and inhibiting factors in recovery after myocardial infarction.

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Depression After Coronary Artery Disease Is Associated With Heart Failure

Abstract: Depression diagnosis was shown to be associated with an increased incidence of HF after CAD diagnosis, regardless of ADM treatment. This finding suggests the need to further study the effect of depression on HF risk among CAD patients.

Cited by 61 publications

References 42 publications

Baseline Depressive Symptoms Predict Subsequent Heart Disease; A 20-Year Cohort

Baseline Depressive Symptoms Predict Subsequent Heart Disease; A 20-Year Cohort

Clinical Impact of Subsequent Depression in Patients With a New Diagnosis of Stable Angina

Supporting and inhibiting factors in recovery experienced by the patients after myocardial infarction during an 18-month follow-up

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