Clinical Impact of Subsequent Depression in Patients With a New Diagnosis of Stable Angina

Szpakowski, Natalie; Bennell, Maria C.; Qiu, Feng; Ko, Dennis T.; Tu, Jack V.; Kurdyak, Paul; Wijeysundera, Harindra C.

doi:10.1161/circoutcomes.116.002904

Cited by 18 publications

(3 citation statements)

References 38 publications

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“…Third, due to the high morbidity in the sample and the length of the follow-up period, our study suffered from a high drop-out rate. As the prognosis of patients with CAD and depression is poorer than that of patients with CAD that are not depressed [71,72,73], selection bias may have occurred, leading to an underestimation of the prevalence of depression and reducing the power of our study. Thus, we may have missed other depression loci in CAD patients.…”

Section: Discussionmentioning

confidence: 99%

Association of Genetic Variation at AQP4 Locus with Vascular Depression

Westermair¹,

Munz

Schaich³

et al. 2018

Biomolecules

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Despite its substantial clinical importance, specific genetic variants associated with depression have not yet been identified. We sought to identify genetic variants associated with depression by (a) focusing on a more homogenous subsample (vascular depression) and (b) applying a three-stage approach. First, we contacted 730 participants with a confirmed atherosclerotic disease (coronary artery disease) from a population-based study population (German Myocardial Infarction Family Study IV) for psychiatric assessment with the Mini International Neuropsychiatric Interview. Second, we genotyped these patients using genome-wide single nucleotide polymorphism (SNP) arrays. Third, we characterized the SNP via in-silico analysis. The final sample consisted of 342 patients (78.3% male, age = 63.2 ± 9.9 years), 22.8% with a severe depressive disorder. Variant rs528732638 on chromosome 18q11.2 was a genome-wide significant variant and was associated with 3.6-fold increase in the odds of lifetime depression. The locus belongs to a linkage disequilibrium block showing expression quantitative trait loci effects on three putative cis-regulated genes, including the aquaporin 4 (AQP4) locus. AQP4 is already known to mediate the formation of ischemic edema in the brain and heart, increasing the size and extent of resulting lesions. Our findings indicate that AQP4 may also play a role in the etiopathology of vascular depression.

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Section: Discussionmentioning

confidence: 99%

Association of Genetic Variation at AQP4 Locus with Vascular Depression

Westermair¹,

Munz

Schaich³

et al. 2018

Biomolecules

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“…A study in >22 000 patients with a new diagnosis of stable angina observed that female sex was a predictor of developing depression after coronary angiography. Furthermore, in this cohort, the frequency of depressive symptoms was independently associated with a higher risk of death and admission for MI 29. Similarly, a study in 988 women referred for coronary angiography observed that women with a history of depression were hospitalized more often over 2.3 years of follow‐up than those without a history of depression.…”

Section: Discussionmentioning

confidence: 51%

Sex Differences in Clinical Characteristics, Psychosocial Factors, and Outcomes Among Patients With Stable Coronary Heart Disease: Insights from the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) Trial

Guimarães

Granger

Stebbins

et al. 2017

JAHA

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BackgroundGreater understanding of differences between men and women with coronary heart disease is needed.Methods and ResultsIn this post hoc analysis of the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial, we described psychosocial factors, treatments, and outcomes of men versus women with stable coronary heart disease and explored the association of sex with psychosocial characteristics and cardiovascular risk. Cox proportional hazards models were used to assess the relationship between sex and outcomes. Interactions among sex, psychosocial factors, and the composite of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke were tested. Of 15 828 patients, 2967 (19%) were women. Among women, 21.2% felt often or always stressed at home (versus 9.8% of men), and 19.2% felt often or always sad or depressed (versus 10.1% of men; all P<0.0001). The median duration of follow‐up was 3.7 years (25th–75th percentiles: 3.5–3.8 years). Use of evidence‐based medications for coronary heart disease at baseline and 24 months was similar between sexes, as were event rates for all outcomes analyzed. In the multivariable model including psychosocial measures, female sex was associated with lower cardiovascular risk. There was a statistically significant interaction (P=0.03) such that the lower risk in women varied by depressive symptom frequency, whereby women who were more depressed had a risk similar to men.ConclusionsFemale sex was independently associated with better long‐term clinical outcomes, although this was modified by frequency of depressive symptoms. This suggests that emotional state may be an important target for improving outcomes in patients with coronary heart disease, specifically in women.Clinical Trial RegistrationSTABILITY ClinicalTrials.gov number (NCT00799903).

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“…A study by Thombs et al on patients with acute myocardial infarction (AMI) showed that survivors of AMI have constant depression [11]. Moreover, according to Kaptein et al, symptoms of depression after myocardial infarction are considered important risk factors of developing other cardiac conditions [12].…”

Section: Introductionmentioning

confidence: 99%

Influence of Depression on Physical and Mental Health in Patients with Angina

Alharbi

2020

Preprint

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Purpose: Angina is well known as chest pain caused by insufficient flow of oxygen-rich blood to the cardiac muscle. Although there are several studies showing an association between depression and angina, none of these studies investigated the influence of depression on the physical and mental health of adult patients with angina, which is the overall goal of this study.Methods: This study used a publicly open data source from the Behavioral Risk Factor Surveillance System (BRFSS), 2017, in the United States. The BRFSS questionnaire relating to health, behaviors, and social life was administered to the United States residents through a telephone interview. There were 450,013 participants in this survey. Different statistical methods, including descriptive, inferential, and predictive methods, were conducted through the Statistical Analysis System (version 9.4) to accomplish the goal of this study. Results: Of the 450,013 participants in the BRFSS 2017, 25,389 were adult patients diagnosed with angina. Of these, 22,875 have depression. This study showed that depression had a statistically significant influence on physical and mental health in adult patients with angina.Conclusion: Depression has a significant influence on physical and mental health of adult patients with angina. Depression increased the physical health problems by 61.95% and mental health problems by 33.15% in adult patients with angina.

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Clinical Impact of Subsequent Depression in Patients With a New Diagnosis of Stable Angina

Cited by 18 publications

References 38 publications

Association of Genetic Variation at AQP4 Locus with Vascular Depression

Association of Genetic Variation at AQP4 Locus with Vascular Depression

Sex Differences in Clinical Characteristics, Psychosocial Factors, and Outcomes Among Patients With Stable Coronary Heart Disease: Insights from the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) Trial

Influence of Depression on Physical and Mental Health in Patients with Angina

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