Depressed Splenic Dendritic Cell Antigen Presentation Function Following Trauma-Hemorrhage

Depressed T cell-derived IFN-γ following trauma-hemorrhage: a potential mechanism for diminished APC responses

“…In this regard, Kawasaki et al [31] demonstrated decreased IL-12 release by isolated DC harvested 2 h after trauma-hemorrhage. Furthermore, those depressed DC decreased T cell proliferation of a T-helper cell clone D10.G4.1 [11]. Those studies collectively suggest that APC responses are suppressed early after trauma-hemorrhage thereby initiating immunosuppression.…”

“…In this respect, an intact interaction between APC and T cells has been shown to be crucial for an efficient immune response [19,20]. Recent studies by Kawasaki et al [11] indicate that DC harvested 2 h after trauma-hemorrhage display depressed cytokine release capacities. Despite this information, it remains unknown whether APC are also responsible for persisting immunosuppression after trauma-hemorrhage.…”

“…Moreover, the depression of T cells and APC persists for up to 7 days after traumahemorrhage and is associated with an increased susceptibility to infections [10]. Although APC appear to be the culprit for initiating immunosuppression after trauma and blood loss [11], it remains unknown whether alterations in T cells or APC function are responsible for persisting immunodysfunction under those conditions. The data of the present study might help to further understand the pathophysiological mechanisms of immunodysfunction, thereby allowing the developing of new therapeutic targets for immuno-maintaining therapies.…”