Depressed natural killer cell activity due to decreased natural killer cell population in a vitamin E-deficient patient with Shwachman syndrome: reversible natural killer cell abnormality by α-tocopherol supplementation

Adachi, Naoto; Migita, Masahiro; Ohta, T; Higashi, Akimasa; Matsuda, Ichiro

doi:10.1007/s004310050634

Cited by 19 publications

(7 citation statements)

References 12 publications

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“…Many studies showed VE has a number of vital functions in plants, including the protection of chloroplasts from photooxidative damage (Munne-Bosch and Alegre 2002). Moreover, human nutritional studies have suggested that VE might play an important role in enhancing the function of the immune system (Adachi et al 1997), and the treatment or prevention of a number of serious diseases including cardiovascular disease (Pryor 2000) and cancer (Prasad et al 1999). …”

Section: Introductionmentioning

confidence: 99%

Identification of QTL underlying vitamin E contents in soybean seed among multiple environments

Liu

Han

et al. 2010

Theor Appl Genet

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Vitamin E (VE) in soybean seed has value for foods, medicines, cosmetics, and animal husbandry. Selection for higher VE contents in seeds along with agronomic traits was an important goal for many soybean breeders. In order to map the loci controlling the VE content, F5-derived F6 recombinant inbred lines (RILs) were advanced through single-seed-descent (SSD) to generate a population including 144 RILs. The population was derived from a cross between ‘OAC Bayfield’, a soybean cultivar with high VE content, and ‘Hefeng 25’, a soybean cultivar with low VE content. A total of 107 polymorphic simple sequence repeat markers were used to construct a genetic linkage map. Seed VE contents were analyzed by high performance liquid chromatography for multiple years and locations (Harbin in 2007 and 2008, Hulan in 2008 and Suihua in 2008). Four QTL associated with α-Toc (on four linkage groups, LGs), eight QTL associated with γ-Toc (on eight LGs), four QTL associated with δ-Toc (on four LGs) and five QTL associated with total VE (on four LGs) were identified. A major QTL was detected by marker Satt376 on linkage group C2 and associated with α-Toc (0.0012 > P > 0.0001, 5.0% < R2 < 17.0%, 25.1 < α-Toc < 30.1 μg g−1), total VE (P < 0.0001, 7.0% < R2 < 10.0%, 118.2 < total VE < 478.3 μg g−1). A second QTL detected by marker Satt286 on LG C2 was associated with γ-Toc (0.0003 > P > 0.0001, 6.0% < R2 < 13.0%, 141.5 < γ-Toc < 342.4 μg g−1) and total VE (P < 0.0001, 2.0% < R2 < 9.0%, 353.9 < total VE < 404.0 μg g−1). Another major QTL was detected by marker Satt266 on LG D1b that was associated with α-Toc (0.0002 > P > 0.0001, 4.0% < R2 < 6.0%, 27.7 < α-Toc < 43.7 μg g−1) and γ-Toc (0.0032 > P > 0.0001, 3.0% < R2 < 10.0%, 69.7 < γ-Toc < 345.7 μg g−1). Since beneficial alleles were all from ‘OAC Bayfield’, it was concluded that these three QTL would have great potential value for marker assisted selection for high VE content.

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Section: Introductionmentioning

confidence: 99%

Identification of QTL underlying vitamin E contents in soybean seed among multiple environments

Liu

Han

et al. 2010

Theor Appl Genet

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“…Studies in human nutrition have shown that VE enhances immune system function (Adachi et al. ); prevents or retards the development of cardiovascular diseases and cancers (Stepan et al., ), inflammation (Watcharee et al., ) and ageing; and improves the histopathological changes induced by carbamazepine (Maheswari et al. ).…”

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confidence: 99%

Mapping quantitative trait loci (QTLs) underlying seed vitamin E content in soybean with main, epistatic and QTL × environment effects

Wang

Han

et al. 2016

Plant Breeding

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Soybean (Glycine max (L.) Merr.) seed contains small amounts of tocopherol, a non-enzymatic antioxidant known as lipid-soluble vitamin E (VE). Dietary VE contributes to a decreased risk of chronic diseases in humans and has several beneficial effects on resistance to stress in plants, and increasing VE content is an important breeding goal for increasing the nutritional value of soybean. In this study, quantitative trait loci (QTLs) underlying VE content with main, epistatic and QTL 9 environment effects were identified in a population of F 5 : 6 recombinant inbred lines from a cross between 'Hefeng 25' (a low-VE cultivar) and 'OAC Bayfield' (a high-VE cultivar). A total of 18 QTLs were detected that showed additive main effects (a) and/or additive 9 environment interaction effects (ae) in different environments. Moreover, 19 epistatic pairs of QTLs were found to be associated with a-tocopherol (a-Toc), c-tocopherol (c-Toc), d-tocopherol (d-Toc) and total VE (TE) contents. The QTLs identified in multienvironments could provide more information about QTL by environment interactions and could be useful for the marker-assistant selection of soybean cultivars with high seed VE contents.

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“…Likewise, dietary supplementation with vitamin E (250 mg daily for 2 wk) can enhance NK cell cytolytic activity in advanced colorectal cancer cells obtained from patients [11]. Interestingly, the supplementation of vitamin E (administered at 100 mg/day for 8 wk) restored NK cell activity in a 16-month-old boy with Shwachman-Diamond syndrome which is classically associated with a persistent reduction in NK cytolytic activity [12]. Collectively, these findings suggest the involvement of dietary components in the regulation of NK cell tumoricidal activity.…”

Section: Dietary Influence On Nk Cell Propertiesmentioning

confidence: 98%

Impact of dietary components on NK and Treg cell function for cancer prevention

et al. 2015

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An important characteristic of cancer is that the disease can overcome the surveillance of the immune system. A possible explanation for this resistance arises from the ability of tumor cells to block the tumoricidal activity of host immune cells such as natural killer (NK) cells by inducing the localized accumulation of regulatory T (Treg) cells. Evidence exists that components in commonly consumed foods including vitamins A, D, and E, water-soluble constituents of mushrooms, polyphenolics in fruits and vegetables, and n-3 fatty acids in fish oil can modulate NK cell activities, Treg cell properties, and the interactions between those two cell types. Thus, it is extremely important for cancer prevention to understand the involvement of dietary components with the early stage dynamics of interactions among these immune cells. This review addresses the potential significance of diet in supporting the function of NK cells, Treg cells, and the balance between those two cell types, which ultimately results in decreased cancer risk.

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Depressed natural killer cell activity due to decreased natural killer cell population in a vitamin E-deficient patient with Shwachman syndrome: reversible natural killer cell abnormality by α-tocopherol supplementation

Abstract: These results indicate that severe vitamin E deficiency caused impaired NK cell activity due to a decrease in the number of CD16+ CD56- NK cells and that this abnormality is reversible with alpha-Toc supplementation.

Cited by 19 publications

References 12 publications

Identification of QTL underlying vitamin E contents in soybean seed among multiple environments

Identification of QTL underlying vitamin E contents in soybean seed among multiple environments

Mapping quantitative trait loci (QTLs) underlying seed vitamin E content in soybean with main, epistatic and QTL × environment effects

Impact of dietary components on NK and Treg cell function for cancer prevention

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