Depressed mood amplifies heart-related symptoms in persistent and paroxysmal atrial fibrillation patients: a longitudinal analysis—data from the German Competence Network on Atrial Fibrillation

Rothe, Alexander von Eisenhart; Hutt, Frederick; Baumert, Jens; Breithardt, G.; Goette, Andreas; Kirchhof, Paulus; Ladwig, Karl‐Heinz

doi:10.1093/europace/euv018

Cited by 48 publications

(43 citation statements)

References 19 publications

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“…U pacjentów z AF często stwierdza się zmiany w istocie białej mózgu, zaburzenia czynności poznawczych [28][29][30], pogorszenie jakości życia [31,32] oraz obniżony nastrój [33], a każdego roku jest hospitalizowanych 10-40% pacjentów z AF [23,34,35]. Bezpośrednie koszty AF stanowią już w przybliżeniu 1% wszystkich wydatków na opiekę zdrowotną w Wielkiej Brytanii, a w Stanach Zjednoczonych w 2008 roku wyniosły 6-26 mld dolarów [36,37], co wynika z powikłań związanych z AF (np.…”

Section: Zgonunclassified

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Kirchhof

Benussi

Kotecha³

et al. 2016

Kardiol Pol

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4,206

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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Kirchhof

Benussi

Kotecha³

et al. 2016

Kardiol Pol

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2,379

4,206

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“…Symptoms of depression and/or anxiety are associated with greater symptom severity of AF (8–10), and with recurrence of AF (7). Furthermore, depressive mood has been shown to be more common among patients with persistent AF than paroxysmal AF (11).…”

Section: Introductionmentioning

confidence: 99%

Depression or anxiety and all-cause mortality in adults with atrial fibrillation – A cohort study in Swedish primary care

et al. 2016

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Objective Our aim was to study depression and anxiety in atrial fibrillation (AF) patients as risk factors for all-cause mortality in a primary care setting. Methods The study population included adults (n = 12 283) of 45 years and older diagnosed with AF in 75 primary care centres in Sweden. The association between depression or anxiety and all-cause mortality was explored using Cox regression analysis, with hazard ratios (HRs) and 95% confidence intervals (95% CIs). Analyses were conducted in men and women, adjusted for age, educational level, marital status, neighborhood socio-economic status (SES), change of neighborhood status and anxiety or depression, respectively, and cardiovascular co-morbidities. As a secondary analysis, background factors and their association with depression or anxiety were explored. Results The risk of all-cause mortality was higher among men with depression compared to their counterparts without depression even after full adjustment (HR = 1.28, 95% CI 1.08–1.53). For anxiety among men and anxiety or depression among women with AF, no associations were found. Cerebrovascular disease was more common among depressed AF patients. Conclusions Increased awareness of the higher mortality among men with AF and subsequent depression is called for. We suggest a tight follow-up and treatment of both ailments in clinical practice.

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“…The association between psychosocial factors and CVDs has long been recognized, and a recent meta-analysis of prospective epidemiological studies found that psychological factors predict cardiovascular morbidity and mortality [ 1 , 2 ]. Specifically, depression has been associated with coronary heart disease (CHD) [ 3 , 4 ], and with atrial fibrillation [ 5 , 6 ]. After acute coronary syndrome (ACS), depression is a risk factor for all cause and cardiac mortality, as well as for composite outcomes including mortality or non-fatal cardiac events [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Depression and Cardiovascular Disease: The Viewpoint of Platelets

Amadio

Zara

Sandrini

et al. 2020

IJMS

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Depression is a major cause of morbidity and low quality of life among patients with cardiovascular disease (CVD), and it is now considered as an independent risk factor for major adverse cardiovascular events. Increasing evidence indicates not only that depression worsens the prognosis of cardiac events, but also that a cross-vulnerability between the two conditions occurs. Among the several mechanisms proposed to explain this interplay, platelet activation is the more attractive, seeing platelets as potential mirror of the brain function. In this review, we dissected the mechanisms linking depression and CVD highlighting the critical role of platelet behavior during depression as trigger of cardiovascular complication. In particular, we will discuss the relationship between depression and molecules involved in the CVD (e.g., catecholamines, adipokines, lipids, reactive oxygen species, and chemokines), emphasizing their impact on platelet activation and related mechanisms.

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Depressed mood amplifies heart-related symptoms in persistent and paroxysmal atrial fibrillation patients: a longitudinal analysis—data from the German Competence Network on Atrial Fibrillation

Abstract: Depressed mood is associated with AF symptom burden over 6 months after adjustment for perceived frequency and duration of AF episodes, COPD, and sex.

Cited by 48 publications

References 19 publications

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Depression or anxiety and all-cause mortality in adults with atrial fibrillation – A cohort study in Swedish primary care

Depression and Cardiovascular Disease: The Viewpoint of Platelets

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