Depressed Lymphocyte Function after Measles-Mumps-Rubella Vaccination

Munyer, Thomas P.; Mangi, Richard J.; Dolan, Thomas F.; Kantor, Fred S.

doi:10.1093/infdis/132.1.75

Cited by 40 publications

(16 citation statements)

References 8 publications

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“…This differential inhibitory effect on specific antigenic response but not on mitogenic response is similar to that reported after vaccination with live viral vaccines (8,17) and after treatment with corticosteroids (2, 7) and cytotoxic drugs (1). However, it is possible that this difference could be related to the fact that cultures stimulated with antigens were incubated longer (6 days) than those incubated with mi- (4,10,11).…”

Section: Discussionsupporting

confidence: 84%

Amphotericin B and 5-Fluorocytosine: In Vitro Effects on Lymphocyte Function

Roselle

Kauffman

1978

Antimicrob Agents Chemother

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The effects of amphotericin B, 5-fluorocytosine, and the combination of both drugs on lymphocyte function in vitro were investigated. Amphotericin B, alone or in combination with 5-fluorocytosine, significantly suppressed both spontaneous lymphocyte transforTnation and the response of lymphocytes to stimulation with streptokinse-streptodornase. 5-Fluorocytosine had no 273, 1977). However, immunostimulatory effects of AmB also have been reported in murine systems (4,10,11,14,15,20). The effects of 5-FC and the combination of 5-FC and AmB on the immune system have not been studied.The effects of these antifungal agents on the immune system may be of great significance in the treatment of patients with fungal diseases. Immunosuppression could be detrimental to successful treatment of fungal infections. On the other hand, immunostimulatory effects of antifungal antibiotics could prove to be a useful adjunct to host defenses against fungi. This study specifically evaluated the effect of AmB, 5-FC, and the combination of both drugs on Band T-lymphocyte function in vitro. MATERIALS AND METHODS

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Section: Discussionsupporting

confidence: 84%

Amphotericin B and 5-Fluorocytosine: In Vitro Effects on Lymphocyte Function

Roselle

Kauffman

1978

Antimicrob Agents Chemother

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“…A number of studies have also reported altered T-cell function after primary measles vaccination. For instance, in Bangladeshi infants, Candida delayed-type hypersensitivity was reduced after measles vaccination (27) and many, but not all, studies have reported decreased in vitro lymphoproliferative responses to PHA, concanavalin A, TT, or purified protein derivative (13) after measles or MMR primary immunization (19,21,29). In the present study, proliferative responses to PHA and TT were unchanged.…”

Section: Discussionsupporting

confidence: 39%

“…Also, a decrease in WBCs was observed in Canadian and Israeli children 1 month after revaccination with MMR (24,32). However, WBCs were unchanged 2 and 12 weeks after primary vaccination of 6-to 9-month-old South African infants with the Edmonston-Zagreb or Schwarz strains of measles vaccine (13) or after primary vaccination of 1-to 8-year-old children with MMR (19). We found no effect of primary vaccination on WBCs, lymphocyte percentages, or CD4/CD8 ratios after primary vaccination of 1-year-old infants with MMR, further suggesting that primary vaccination with the current vaccine has little effect on these parameters.…”

Section: Discussionmentioning

confidence: 95%

Differential Immune Responses to Primary Measles-Mumps-Rubella Vaccination in Israeli Children

Rager-Zisman

Bazarsky²,

Skibin³

et al. 2004

Clin Vaccine Immunol

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Measles remains an important cause of morbidity and mortality worldwide, primarily due to problems associated with delivery of the live attenuated vaccine to susceptible populations. In some developed countries, there is concern about the effects of immunization on the immune system. In this study, we analyzed the responses of 12-month-old Bedouin and Jewish children living in Israel to routine measles-mumps-rubella (MMR) vaccination. Seroconversion to measles was 99% in Bedouin and 79% in Jewish children (P < 0.01), and that to mumps and rubella was 92 to 100% in both groups. Measles neutralizing antibody titers were higher in Bedouin (333 ؎ 39 mIU/ml) than Jewish (122 ؎ 60 mIU/ml) children (P < 0.002). Immunoglobulin G levels were higher in Bedouin than Jewish children (P ‫؍‬ 0.007) and increased after vaccination (P ‫؍‬ 0.0009). Leukocyte (P < 0.02) and lymphocyte (P ‫؍‬ 0.04) counts were higher and CD4 lymphocyte percentages were lower (P < 0.001) in Bedouin than Jewish children before and after vaccination. Leukocyte counts and natural killer cell numbers did not change after vaccination, but lytic activity increased in Bedouin children (P < 0.005). Spontaneous proliferation of cultured peripheral blood mononuclear cells increased with vaccination, but there were no changes in the proliferative responses to phytohemagglutinin or tetanus toxoid. In summary, no adverse effects of MMR vaccination on immune function were detected. However, there were differences in underlying immunologic parameters and in response to the measles component of the vaccine between Bedouin and Jewish children. It is not known whether genetic differences or environmental exposure accounts for these differences.

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“…Earlier studies of the cellular composition of clini- 6,12,24,36, and 48 h. The cover slips were air-dried and Wright's-stained. As a control on possible variations in staining from day to day, a stored peripheral blood smear known to contain basophils was also stained.…”

Section: Introductionmentioning

confidence: 99%

“…Blood collection and in vitro studies. Before skin testing, blood was collected from some subjects, selected at random, for in vitro lymphocyte culture in quadruplicate wells of microtrays, by a previously described method (12). A stored autologous serum pool from a set group of three unimmunized normal persons was used to support the cell cultures.…”

Section: Introductionmentioning

confidence: 99%

Basophils in tuberculin and "Jones-Mote" delayed reactions of humans.

Askenase¹,

Atwood²

1976

J. Clin. Invest.

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A B S T R A C T Jones-Mote reactions are delayed, erythematous, and mildly indurated cutaneous reactions originally described in humans sensitized by skin injection of heterologous proteins. Similar reactions in guinea pigs contain many basophils and are called cutaneous basophil hypersensitivity. In contrast, guinea pigs immunized with mycobacterial adjuvants have classical tuberculin-type delayed hypersensitivity reactions, which contain few basophils. This has led to a new classification of delayed responses, based largely on the presence or absence of basophils. We induced sensitization for JonesMote reactions in 20 normal humans by intradermal injections of keyhole limpet hemocyanin. Skin tests with KLH 1 wk later showed erythematous and indurated delayed reactions in all subjects. Rebuck skin windows showed specific accumulations of basophils with a delayed time-course in 18 of 20 subjects. In 12 normals sensitized with oxazolone-keyhole limpet hemocyanin conjugates, skin reactions and in vitro lymphocyte stimulation showed carrier and not hapten specificity, suggesting that cutaneous responses were probably mediated by T cells.A comparative stuidy of strongly positive PPD skin tests in patients with tuiberctulosis showed significant basophil accuimulations in five of nine subjects. Thus, basophils occuirred in human tuibercullin and Jones-Mote reactions and were not a distinguishing feature of Jones-Mote reactions. We suggest that the occurrence of basophils at delayed reactions is under complex regulation and that basophil accumulations are an aspect of delayed hypersensitivity, rather than an indication of a distinctive and separate response. Dr. Askenase is the recipient of Allergic DiseasesAcademic Award AI-70829, and Dr. Atwood was the recipient of a student fellowship from the Syntex Corporation.

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Depressed Lymphocyte Function after Measles-Mumps-Rubella Vaccination

Cited by 40 publications

References 8 publications

Amphotericin B and 5-Fluorocytosine: In Vitro Effects on Lymphocyte Function

Amphotericin B and 5-Fluorocytosine: In Vitro Effects on Lymphocyte Function

Differential Immune Responses to Primary Measles-Mumps-Rubella Vaccination in Israeli Children

Basophils in tuberculin and "Jones-Mote" delayed reactions of humans.

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