Deposition of thin titanium–copper films with antimicrobial effect by advanced magnetron sputtering methods

Straňák, Vítězslav; Wulff, H.; Rebl, Henrike; Zietz, Carmen; Arndt, K.; Bogdanowicz, Robert; Nebe, Barbara; Bader, Rainer; Podbielski, Andreas; Hubička, Zdeněk; Hippler, R.

doi:10.1016/j.msec.2011.06.009

Cited by 118 publications

(80 citation statements)

References 34 publications

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“…5a, trace 6) shows almost no bacterial inactivation under light as it was the case for the TNTZ-(Cu) 8 sample in the dark. Generally, the interactions between coating and bacteria have been shown to depend on the contact surface size, redox potentials and hydrophilic-hydrophobic properties [10,11]. In this study we have shown that the RMS roughness (Fig.…”

Section: Morphology and Surface Topography Of Films Observed By Sem Asupporting

confidence: 51%

Beneficial effect of Cu on Ti-Nb-Ta-Zr sputtered uniform/adhesive gum films accelerating bacterial inactivation under indoor visible light

Alhussein

Achache

Déturche

et al. 2017

Colloids and Surfaces B: Biointerfaces

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a b s t r a c tThis article presents the evidence for the significant effect of copper accelerating the bacterial inactivation on Ti-Nb-Ta-Zr (TNTZ) sputtered films on glass up to a Cu content of 8.3 at.%. These films were deposited by dc magnetron co-sputtering of an alloy target Ti-23Nb-0.7Ta-2Zr (at.%) and a Cu target. The fastest bacterial inactivation of E. coli on this later TNTZ-Cu surface proceeded within ∼75 min. The films deposited by magnetron sputtering are chemically homogenous. The film roughness evaluated by atomic force spectroscopy (AFM) on the TNTZ-Cu 8.3 at.% Cu sample presented an RMS-value of 20.1 nm being the highest RMS of any Cu-sputtered TNTZ sample. The implication of the RMS value found for this sample leading to the fastest interfacial bacterial inactivation kinetics is also discussed. Values for the Young's modulus and hardness are reported for the TNTZ films in the presence of various Cu-contents. Evaluation of the bacterial inactivation kinetics of E. coli under low intensity actinic hospital light and in the dark was carried out. The stable repetitive bacterial inactivation was consistent with the extremely low Cu-ion release from the samples of 0.4 ppb. Evidence is presented by the bacterial inactivation dependence on the applied light intensity for the intervention of Cu as semiconductor CuO during the bacterial inactivation at the TNTZ-Cu interface. The mechanism of CuO-intervention under light is suggested based on the pH/and potential changes registered during bacterial disinfection.

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Section: Morphology and Surface Topography Of Films Observed By Sem Asupporting

confidence: 51%

Beneficial effect of Cu on Ti-Nb-Ta-Zr sputtered uniform/adhesive gum films accelerating bacterial inactivation under indoor visible light

Alhussein

Achache

Déturche

et al. 2017

Colloids and Surfaces B: Biointerfaces

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“…Initiatives to minimize bacterial colonization at the time of insertion have been studied in the past with slow permeation in the clinical setting [1,39,48]. Several preclinical and clinical studies support the use of copper alloy touch surfaces to reduce the burden of bacteria in healthcare settings [10,11,33], but few studies support the use of copper implants to reduce periprosthetic infections [6,18,27,41]. The ideal antibacterial coating should be biocompatible, thin, dense, and firm with precise decay of the active material.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, we chose titanium copper oxide coating because while copper ions are eluting, titanium oxide theoretically provided corrosion resistance to the substrate [3]. However, there are many other coatings containing copper that could have similar or potentially even better performance (eg, titanium-copper, copper-nickel, titaniumcoper-nitride, titanium-silver-copper) [5,6,18,22,41,44]. Also, we chose HiPIMS, a physical vapor deposition method, for coating because it enables deposition of dense, firm, and thin films.…”

Section: Discussionmentioning

confidence: 99%

“…After 24 hours no planktonic or adherent S aureus was found in contrast to the uncoated plates on which 1.05 9 10 5 CFU/mL of planktonic bacteria was detected in the incubation fluids and 2.45 9 10 5 CFU/mL adherent bacteria in the rinsed fluids. Stranak et al [41] presented the antibacterial profile of titanium-copper (Ti-Cu) thin film deposited using different plasma-assisted magnetron sputtering methods. They obtained similar antibacteria effect against S epidermidis compared with our results.…”

Section: Discussionmentioning

confidence: 99%

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Antibacterial and Biocompatible Titanium-Copper Oxide Coating May Be a Potential Strategy to Reduce Periprosthetic Infection: An In Vitro Study

Norambuena

Patel

Karau

et al. 2017

Clinical Orthopaedics &Amp; Related Research

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Background Periprosthetic infections are devastating for patients and more efficacious preventive strategies are needed. Surface-modified implants using antibacterial coatings represent an option to cope with this problem; however, manufacturing limitations and cytotoxicity have curbed clinical translation. Among metals with antibacterial properties, copper has shown superior in vitro antibacterial performance while maintaining an acceptable cytotoxicity profile. A thin film containing copper could prevent early biofilm formation to limit periprosthetic infections. This pilot study presents the in vitro antibacterial effect, cytotoxicity, and copper ion elution pattern of a thin film of titanium-copper oxide (TiCuO). Questions/purposes (1) Do titanium alloy (Ti6Al4V) discs coated with a thin film of TiCuO reduce Staphylococcus epidermidis biofilm and planktonic cell density compared with uncoated discs? (2) Do Ti6Al4V discs coated with a thin film of TiCuO affect normal human osteoblast viability compared with untreated cells? (3) Is copper ion concentration generated by coated discs lower than previously published copper ion concentrations that cause 50% toxicity in similar human cell lines in vitro (TC50)? Methods Ninety Ti6Al4V discs (12.5 mm diameter; 1.25 mm thick) were used in this study. Seventy-two Ti6Al4V discs were coated with a thin film of either titanium oxide (TiO) or TiCuO containing 20%, 40%, or 80% copper using high-power impulse magnetron sputtering (HiPIMS). Eighteen Ti6Al4V discs remained uncoated for control purposes. We tested antibacterial properties of S epidermidis grown on The institution of one or more of the authors (GAN, RP, MK, CCW, PJJ, KEB, ADH, RJS) has received funding in excess of USD 100,000 from Codelco (Codelco Lab, Santiago, Chile; FP00076314-01-S01) and in excess of USD 10,000 from the Mayo Clinic. With the exception of one of the authors (RJS), the investigators have not personally received any money related to this study. One of the authors certifies that he (RJS), or a member of his immediate family, has received or may receive payments or benefits, during the study period, in an amount of USD 10,000 to USD 100,000 from Biomet Inc (Warsaw, IN, USA Clinical Orthopaedics and Related Research ®A Publication of The Association of Bone and Joint Surgeons® discs in wells containing growth medium. After 24 hours, planktonic bacteria as well as biofilms removed by sonication were quantitatively cultured. Annexin/Pi staining was used to quantify in vitro normal human osteoblast cell viability at 24 hours and Day 7, respectively. Copper elution was measured at Days 1, 2, 3, 7, 14, and 28 using an inductively coupled plasma mass spectrometer to analyze aliquots of culture medium. Copper ion concentration achieved at 24 hours was compared with previously published TC50 for gingival fibroblast, a phenotypically similar cell line with available data regarding copper ion exposure. Results Discs coated with TiCuO 80% copper showed greater biofilm and planktonic cell density re...

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“…A second component of the inter-metallic alloy was titanium, which was used to increase adhesion to TiAlV surfaces and to increase the hardness of the Ti-Cu films (Stranak et al 2011). Differential antimicrobial effects of Cu and Ti-Cu films were detected and, moreover, differences in the susceptibility of the two species towards Ti-Cu films could be observed.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antimicrobial effects of novel implant materials by testing the prevention of biofilm formation using a simple small scale medium-throughput growth inhibition assay

et al. 2012

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Deposition of thin titanium–copper films with antimicrobial effect by advanced magnetron sputtering methods

Cited by 118 publications

References 34 publications

Beneficial effect of Cu on Ti-Nb-Ta-Zr sputtered uniform/adhesive gum films accelerating bacterial inactivation under indoor visible light

Beneficial effect of Cu on Ti-Nb-Ta-Zr sputtered uniform/adhesive gum films accelerating bacterial inactivation under indoor visible light

Antibacterial and Biocompatible Titanium-Copper Oxide Coating May Be a Potential Strategy to Reduce Periprosthetic Infection: An In Vitro Study

Evaluation of antimicrobial effects of novel implant materials by testing the prevention of biofilm formation using a simple small scale medium-throughput growth inhibition assay

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