Deposition of Particles

Brown, James S.

doi:10.1016/b978-0-12-404577-4.00027-8

Cited by 24 publications

(18 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The main mechanisms of particle deposition are: impaction, sedimentation, and diffusion. Brown [37] proposed that particle deposition in the respiratory tract is minimal in the range 0.1-1.0 µm because particles in this size range are small for sedimentation/impaction and large for diffusion.…”

Section: Health Risk Assessment Methodology For Particle-bound Metalsmentioning

confidence: 99%

Characterization of Human Health Risks from Particulate Air Pollution in Selected European Cities

et al. 2019

View full text Add to dashboard Cite

The objective of the current study was to estimate health risk indexes caused by the inhalation of particulate matter (PM) by adult males and children using data sampled in three European cities (Athens, Kuopio, Lisbon). Accordingly, the cancer risk (CR) and the hazard quotient (HQ) were estimated from particle-bound metal concentrations whilst the epidemiology-based excess risk (ER), the attributable fraction (AF), and the mortality cases were obtained due to exposure to PM10 and PM2.5. CR and HQ were estimated using two methodologies: the first methodology incorporated the particle-bound metal concentrations (As, Cd, Co, Cr, Mn, Ni, Pb) whereas the second methodology used the deposited dose rate of particle-bound metals in the respiratory tract. The indoor concentration accounts for 70% infiltration from outdoor air for the time activity periods allocated to indoor environments. HQ was lower than 1 and the cumulative CR was lower than the acceptable level (10−4), although individual CR for some metals exceeded the acceptable limit (10−6). In a lifetime the estimated number of attributable cancer cases was 74, 0.107, and 217 in Athens, Kuopio, and Lisbon, respectively. Excess risk-based mortality estimates (due to outdoor pollution) for fine particles were 3930, 44.1, and 2820 attributable deaths in Athens, Kuopio, and Lisbon, respectively.

show abstract

Section: Health Risk Assessment Methodology For Particle-bound Metalsmentioning

confidence: 99%

Characterization of Human Health Risks from Particulate Air Pollution in Selected European Cities

et al. 2019

View full text Add to dashboard Cite

show abstract

“…PM2,5 dapat menembus pertahanan sistem saluran pernapasan manusia sehingga dapat terikat oleh darah manusia melalui pertukaran udara pada alveolus di paruparu. Partikulat dapat mengendap dalam saluran pernafasan melalui beragam mekanisme fisik antara lain sedimentasi, impaksi, difusi, intersepsi, dan elektronik presipitasi (Brown, 2015).…”

Section: Pendahuluanunclassified

Risiko Kesehatan Pajanan Pm2,5 Di Udara Ambien Pada Pedagang Kaki Lima Di Bawah Flyover Pasar Pagi Asemka Jakarta

Sembiring¹

2020

jtl

View full text Add to dashboard Cite

Pencemaran udara merupakan salah satu permasalahan kota metropolitan seperti DKI Jakarta. Pemantauan kualitas udara DKI Jakarta sepanjang tahun 2018 -2019 oleh AirVisual dengan parameter kritis PM2,5 menunjukkan kondisi tidak sehat. Debu partikulat berukuran lebih kecil 2,5 mikron (PM2,5) sebagai salah satu polutan dari emisi yang dapat masuk dan menembus sistem saluran pernapasan manusia dan terikat darah melalui pertukaran gas pada alveolus paru sehingga dapat menyebabkan deposit pada alveolus dan mengakibatkan kerusakan sel. Tujuan penelitian ini adalah untuk menganalisis risiko kesehatan pada pedagang kaki lima karena adanya PM2,5 pada kondisi realtime. Penelitian ini merupakan sebuah observasi dengan menggunakan metode Analisis Risiko Kesehatan. Pengukuran berat badan, waktu pajanan harian, frekuensi pajanan dan lama pajanan diukur dari 60 pedagang kaki lima berjenis kelamin pria yang bekerja di bawah Flyover Pasar Pagi Asemka Jakarta Barat. Pasar Pagi Asemka Jakarta Barat merupakan sebuah area perdagangan yang berdekatan dengan jalan yang ramai. Konsentrasi polutan PM2,5 di udara ambien diperoleh dari data pemantauan AirVisual di Mangga Besar yang berlangsung selama 24 jam selama 7 hari. Estimasi risiko kesehatan dinyatakan dalam Risk Quotient (RQ) berdasarkan intake risk agent dan dosis referensinya (RfC). Pemantauan konsentrasi PM2,5 sebesar 35,1 µg/Nm 3 pada kondisi minimum, 116 µg/Nm 3 pada kondisi maksimum, dan dengan rata-rata 56,71 µg/Nm 3 . Hasil penelitian menunjukkan RQ<1 dalam pajanan realtime dapat diterima. Namun harus diwaspadai adanya perubahan iklim, kondisi alam dan peningkatan aktivitas lalulintas. Oleh karena itu upaya pemantauan, pengawasan, maupun pembinaan oleh pihak pemerintah akan sangat dibutuhkan untuk meminimalisir adanya gangguan kesehatan serta menanam pohon-pohon yang dapat menyerap polutan udara di sekitar jalan raya.

show abstract

“…It is assumed that larger particles cannot reach the deep lung and that particles <1 µm are exhaled to ~100% due to their low settling velocity. Deposition of <0.01 µm particles is due to diffusive deposition and of 5–10 µm particles due to sedimentation and impactation [42]. Several other models exist that suggest similar size preferences for deposition (see available reviews for instance [43,44]).…”

Section: Particle Action In the Deep Lungmentioning

confidence: 99%

“…Abnormal airway branching, however, was also described in smoking subjects, patients with heart disease, lung cancer, stroke, and other diseases [54]. It has also been shown that the average dose/surface area of ≥0.01 µm particles at the bifurcation of the trachea is 100–500 times higher than at other regions of the lung [42]. It is hypothesized that the preferential localization of bronchial carcinoma in these areas is due to the fact that particles containing environmental toxicants also deposit there [55].…”

Section: Particle Action In the Deep Lungmentioning

confidence: 99%

Biological Obstacles for Identifying In Vitro-In Vivo Correlations of Orally Inhaled Formulations

Frőhlich

2019

Pharmaceutics

View full text Add to dashboard Cite

Oral inhalation of drugs is the classic therapy of obstructive lung diseases. In contrast to the oral route, the link between in vitro and in vivo findings is less well defined and predictive models and parameters for in vitro-in vivo correlations are missing. Frequently used in vitro models and problems in obtaining in vivo values to establish such models and to identify the action of formulations in vivo are discussed. It may be concluded that major obstacles to link in vitro parameters on in vivo action include lack of treatment adherence and incorrect use of inhalers by patients, variation in inhaler performance, changes by humidity, uncertainties about lung deposition, and difficulties to measure drug levels in epithelial lining fluid and tissue. Physiologically more relevant in vitro models, improvement in inhaler performance, and better techniques for in vivo measurements may help to better understand importance and interactions between individual in vitro parameters in pulmonary delivery.

show abstract

Deposition of Particles

Cited by 24 publications

References 108 publications

Characterization of Human Health Risks from Particulate Air Pollution in Selected European Cities

Characterization of Human Health Risks from Particulate Air Pollution in Selected European Cities

Risiko Kesehatan Pajanan Pm2,5 Di Udara Ambien Pada Pedagang Kaki Lima Di Bawah Flyover Pasar Pagi Asemka Jakarta

Biological Obstacles for Identifying In Vitro-In Vivo Correlations of Orally Inhaled Formulations

Contact Info

Product

Resources

About