Deposition of Iron(III) Hydroxide on Aggregations of Several Proteins

Abstract

We have found that deposition of the iron(III) hydroxide occurred rapidly on the aggregates of amyloid beta-peptide (1-40), transferrin, and albumin induced by zinc(II) chloride in the solution containing iron(III) compounds with amino acid derivatives; the deposition of iron(III) hydroxide may proceed via the coordination of nitrogen and oxygen atoms of the amino acid residues of the aggregated proteins to the iron(III) ion, implying that iron(III) compounds with amino acids or peptides in plasma, so-called "non-specific iron," should be an intrinsic iron(III)-ion carrier to induce the high level accumulation of iron(III) ions in the amyloid deposits.

The chemical mechanism of oxidative stress by copper(II) and iron(III) ions in several neurodegenerative disorders

“…We have found that deposition of iron(III) hydroxide occurs readily on the aggregates of amyloid beta-peptide [abbreviated as Ab ] by the addition of zinc(II) chloride to the solution containing iron(III) compounds with nta, edda, and other amino acid derivatives [72]. This implies that iron(III) compounds with amino acids or peptides in plasma may be an intrinsic iron(III)-ion carrier to induce the high level accumulation of iron(III) ions in the amyloid deposits.…”