Deposition of Ibuprofen Crystals on Hydroxypropyl Cellulose/Polyacrylamide Gel: Experimental and Mathematic Modeling Releasing

Abstract

The crystallization of nonsteroidal anti-inflammatory drug [2-(4-isobutyl-phenyl) propionic acid] ibuprofen (IBP) on a hydroxypropyl cellulose (HPC) and polyacrylamide (PAAm) gel was studied as well as the release kinetics of the drug. The IBP was crystallized on the gel surface of HPC/PAAm. It had a prismatic shape and the growth was made in an aqueous medium; the crystallinity grade of the gels HPC/PAAm and HPC/PAAm-IBU increased to 68% and to 58%, respectively. The release of IBP is performed by two means: by a non-Fickian diffusion process and by relaxation of the chains of the gel; without regard to temperature and the diffusion media, this correlates with the lower critical solution temperature (LCST) of the proposed gel. This polymer matrix provides an option for releasing nonsteroidal anti-inflammatory drugs in a temperature range of 35–39°C. Korsmeyer and Peppas mathematical model was simulated for data releases, statistically significant at 95% confidence level.

Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application

“…According to [33], fully miscible systems of two compounds present a single T g , even when each compound in the composite has its own T g . Similarly, Castillo-Miranda et al [3] reported a single exothermic peak, corresponding to the melting point of the active substance, in a DSC thermogram of HPC/PAAm gel with incorporated International Journal of Polymer Science ibuprofen. This supports the statement that acetaminophen was correctly incorporated into the HPC/PAAm gel, previously established based on the FTIR results.…”

“…Castillo-Miranda et al [3] modelled ibuprofen release in HPC/PAAm gel by the traditional methods (Equations (1)-(4)), and the best adjustments were obtained with the Korsmeyer-Peppas model, meaning that the release of drug in HPC/PAAm gel occurred through the viscoelastic relaxation of the polymer, as a non-Fickian phenomenon. Therefore, it was decided to model the acetaminophen release in HPC/PAAm gel with the Korsmeyer-Peppas model, assuming that acetaminophen release would also occur through the viscoelastic relaxation of the polymer, since the hydrogel used as DDS was the same.…”

“…Currently, numerous scientific researches on hydrogels as Drug Delivery Systems have been reported in [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Hydroxypropyl cellulose with polyacrylamide (HPC/PAAm) is a particularly interesting hydrogel because it is biodegradable.…”

“…Hydroxypropyl cellulose with polyacrylamide (HPC/PAAm) is a particularly interesting hydrogel because it is biodegradable. Castillo-Miranda et al reported in [3] a study on the crystallization of (RS)-2-(4-isobutylphenyl)propionic acid, a drug commonly known as ibuprofen, within a HPC/PAAm gel, as well as the kinetics of drug release in it. The drug release tests were performed at three temperatures (35,37, and 39°C) and using two different solvents: a buffer solution of water and phosphate with a pH of 7.38 and a (50 : 50) mixture of ethanol with water with pH 7.…”

“…The drug release tests were performed at three temperatures (35,37, and 39°C) and using two different solvents: a buffer solution of water and phosphate with a pH of 7.38 and a (50 : 50) mixture of ethanol with water with pH 7. The drug release was modelled with the zero-order, first order, Higuchi, and Korsmeyer-Peppas models, represented in Equations (1), (2), (3), and (4), respectively. In most cases, the best adjustments were found with the Korsmeyer-Peppas model, meaning that the drug was released as part of a non-Fickian phenomenon, through the viscoelastic relaxation of the polymer.…”