Depletion of hsa_circ_0000144 Suppresses Oxaliplatin Resistance of Gastric Cancer Cells by Regulating miR-502-5p/ADAM9 Axis

Gao, Haifeng; Xu, Jiajia; Qiao, Fen; Xue, Liyan

doi:10.2147/ott.s281238

Cited by 14 publications

(16 citation statements)

References 39 publications

(42 reference statements)

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“…Another circRNA circMCTP2 is reported to inhibit CDDP resistance of GC cells via the miR-99a-5p /MTMR3 axis [ 108 ]. The circRNA hsa_circ_0000144 exerts inhibitory effects on OXA resistance, GC cell proliferation, and metastasis through up-regulating ADAM9 mediated by miR-502-5p [ 109 ]. Bupivacaine, a local anesthetic commonly used in the resection operation of GC patients, reduces the circ_0000376 level in GC cells, and circ_0000376 partially reverses bupivacaine-mediated repressive effects on GC cell viability and metastasis via sponging miR-145-5p [ 110 ].…”

Section: Interplay Between Circrnas and Drug Resistance In Gcmentioning

confidence: 99%

“…On the other hand, various circRNAs reverse drug resistance in GC treatment [107][108][109]. Peng et al have unveiled that circCUL2 displays a decreased level in GC tissues and possesses a repressively regulatory function in CDDP resistance, GC cell migration, and invasion via miR-142-3p/ROCK2-mediated autophagy activation [107].…”

Section: Interplay Between Circrnas and Drug Resistance In Gcmentioning

confidence: 99%

“…Considering that circRNAs possess unique features such as tissue-and developmental stage-specific patterns, structural resistance to exonucleases and longer halflives, and specific circRNAs play essential roles in GC metastasis and drug resistance, manipulating circRNA abundance appears to be a promising therapeutic strategy for the advanced GC treatment [126-128, 131, 132]. Furthermore, combining circRNAs-based therapeutic interventions with traditional chemotherapy or targeted therapy offers a unique opportunity to conquer drug resistance in advanced GC patients [97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][113][114][115][116][117]. However, choosing crucial target circRNAs of interest is still a problem.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance

Wang

Zhang

Cao

et al. 2022

J Exp Clin Cancer Res

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Gastric cancer (GC) is an aggressive malignancy with a high mortality rate and poor prognosis, primarily caused by metastatic lesions. Improved understanding of GC metastasis at the molecular level yields meaningful insights into potential biomarkers and therapeutic targets. Covalently closed circular RNAs (circRNAs) have emerged as crucial regulators in diverse human cancers including GC. Furthermore, accumulating evidence has demonstrated that circRNAs exhibit the dysregulated patterns in GC and have emerged as crucial regulators in GC invasion and metastasis. However, systematic knowledge regarding the involvement of circRNAs in metastatic GC remains obscure. In this review, we outline the functional circRNAs related to GC metastasis and drug resistance and discuss their underlying mechanisms, providing a comprehensive delineation of circRNA functions on metastatic GC and shedding new light on future therapeutic interventions for GC metastases.

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Section: Interplay Between Circrnas and Drug Resistance In Gcmentioning

confidence: 99%

Section: Interplay Between Circrnas and Drug Resistance In Gcmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance

Wang

Zhang

Cao

et al. 2022

J Exp Clin Cancer Res

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“…hsa_circ_0062019 promotes prostate cancer cell proliferation, migration, and invasion through upregulating HMGA2 by decoying miR-195-5p [22]. Many other studies demonstrate the role of circRNAs in multiple cancer types such as thyroid, gastric, bladder, breast, and colon cancer [23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

CircWalk: A novel approach to predict CircRNA- Disease association based on heterogeneous network representation learning

Kouhsar

Kashaninia

Mardani

et al. 2022

Preprint

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Background: Several types of RNA in the cell are usually involved in biological processes with multiple functions. Generally, coding RNAs translate to proteins, and non-coding ones regulate this translation in the gene regulatory networks. Some single-strand RNAs can create a circular shape via the back splicing process and convert into a new type called circular RNA (circRNA). circRNAs are among the most important non-coding RNAs in the cell that involve multiple disorders. One of the key functions of circRNAs is to regulate the expression of other genes through sponging micro RNAs (miRNAs) in diseases. This mechanism, known as the competing endogenous RNA (ceRNA) hypothesis, and additional information obtained from biological datasets can be used by computational approaches to predict novel associations between disease and circRNAs. Results: We applied multiple classifiers to validate the extracted features from the heterogeneous network and selected the best one based on some evaluation criteria. Then, the XGBoost is utilized in our pipeline to generate a novel approach, called CircWalk, to predict CircRNA-Disease associations. Our results demonstrate that CircWalk has reasonable accuracy and AUC compared with other state-of-the-art algorithms. We also use CircWalk to predict novel circRNAs associated with lung, gastric, and colorectal cancers as a case study. The results show that our approach can accurately predict novel circRNAs related to these diseases. Conclusions: In this study, considering the ceRNA hypothesis, we integrate multiple resources to construct a heterogeneous network from circRNAs, mRNAs, miRNAs, and diseases. Next, the DeepWalk algorithm is applied to the network to extract feature vectors for circRNAs and diseases. The extracted features are used to learn a classifier and generate a model to predict novel CircRNA-Disease associations. Our approach uses the concept of the ceRNA hypothesis and the miRNA sponge effect of circRNAs to predict their associations with diseases. Our results show that this outlook could help anticipate CircRNA-Disease associations more accurately.

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“…CircRNAs are linked to the development of chemoresistance in GC ( Cui et al, 2020 ). For instance, circ_0000144 restrained oxaliplatin (OXA) resistance of GC via altering miR-502-5p and ADAM9 ( Gao et al, 2021 ). CircFN1 promoted the malignancy and DDP resistance of GC via decoying miR-182-5p ( Huang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

CircARVCF Contributes to Cisplatin Resistance in Gastric Cancer by Altering miR-1205 and FGFR1

Zhao

Yuan²,

et al. 2021

Front. Genet.

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Background: Chemoresistance is a major barrier to the treatment of human cancers. Circular RNAs (circRNAs) are implicated in drug resistance in cancers, including gastric cancer (GC). In this study, we aimed to explore the functions of circRNA Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (circARVCF) in cisplatin (DDP) resistance in GC.Methods: The expression of circARVCF, microRNA-1205 (miR-1205) and fibroblast growth factor receptor 1 (FGFR1) was detected by quantitative real-time polymerase chain reaction (qRT-PCR), western blot assay or immunohistochemistry (IHC) assay. Cell Counting Kit-8 (CCK-8) assay and colony formation assay were performed to evaluate DDP resistance and cell colony formation ability. Transwell assay was conducted to assess cell migration and invasion. Flow cytometry analysis was done to analyze cell apoptosis. Dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay were manipulated to analyze the relationships of circARVCF, miR-1205 and FGFR1. Murine xenograft model was constructed to explore DDP resistance in vivo.Results: CircARVCF level was increased in DDP-resistant GC tissues and cells. CircARVCF silencing inhibited DDP resistance, colony formation and metastasis and induced apoptosis in DDP-resistant GC cells. CircARVCF directly interacted with miR-1205 and miR-1205 inhibition reversed circARVCF silencing-mediated effect on DDP resistance in DDP-resistant GC cells. FGFR1 served as the target gene of miR-1205. MiR-1205 overexpression restrained the resistance of DDP-resistant GC cells to DDP, but FGFR1 elevation abated the effect. In addition, circARVCF knockdown repressed DDP resistance in vivo.Conclusion: CircARVCF enhanced DDP resistance in GC by elevating FGFR1 through sponging miR-1205.

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Depletion of hsa_circ_0000144 Suppresses Oxaliplatin Resistance of Gastric Cancer Cells by Regulating miR-502-5p/ADAM9 Axis

Cited by 14 publications

References 39 publications

Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance

Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance

CircWalk: A novel approach to predict CircRNA- Disease association based on heterogeneous network representation learning

CircARVCF Contributes to Cisplatin Resistance in Gastric Cancer by Altering miR-1205 and FGFR1

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