Depigmenting effect of Cinnamomum cassia Presl in B16F10 melanoma cells

Nguyen, Dung; Nguyen, Duc T. M.; La, Lyun-Hwa; Yang, Sanghee; Lee, Hyang‐Bok; Kim, Hae-Jong; Shin, Jeonghyun; Kim, Dong Man; Kim, Eun-Ki

doi:10.1007/s11814-007-0048-0

Cited by 16 publications

(11 citation statements)

References 15 publications

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“…Edible mushrooms are the ideal dietetic materials for the prevention of atherosclerosis due to their high content of fiber, proteins, microelements and their low fat content [11,12]. Recently, a variety of mushroom extract has been investigated in an attempt to apply to anti-diabetic agents [13][14][15].…”

Section: Resultsmentioning

confidence: 99%

Effect of Fomitopsis pinicola extract on blood glucose and lipid metabolism in diabetic rats

Cha

Ding

Shin

et al. 2009

Korean J. Chem. Eng.

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This study was performed to investigate the effects of Fomitopsis pinicola extract on blood glucose and lipid metabolism in diabetic rats. The blood glucose concentration was similar to that of the control at 30 min, but after 60 min of glucose administration the blood glucose concentration rapidly decreased, and after 120 min was 100.7± 4.0 mg/dL, representing an approximate 50% decrease compared to the control. In the case of the diabetic rats induced by streptozotocin, the concentration of blood glucose was decreased from 362.0±16.7 to 204.5±11.4 mg/dL after 20 days of administration. HDL-and LDL-cholesterol concentrations were 39.0±4.3 mg/L and 13.2±3.4 mg/dL, respectively, representing an approximate increase of 73% and approximate decrease of 76%, respectively, compared to the control. The activities of aspartate aminotransferase and alanine transaminase were increased. On the other hand, activities of amylase, alkaline phosphatase, lactate dehydrogenase, glutamic oxaloacetic transaminase, and glutamic pyruvic transaminase were decreased compared to that of the control. No difference was evident between test and control rats with respect to white blood cell, red blood cell, hemocyte, hemoglobin, hematocrit, and platelet counts. These results indicate that F. pinicola extract is useful as a preventative and treatment agent for damage of liver and kidney cells.

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Section: Resultsmentioning

confidence: 99%

Effect of Fomitopsis pinicola extract on blood glucose and lipid metabolism in diabetic rats

Cha

Ding

Shin

et al. 2009

Korean J. Chem. Eng.

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“…Melanin content measurements and cell viability assay were performed as previously reported method . The details of methodology provided in supplementary (SM) information sheet.…”

Section: Methodsmentioning

confidence: 99%

Homology modelling and virtual screening of P‐protein in a quest for novel antimelanogenic agent and In vitro assessments

Morya

Dung

Singh

et al. 2014

Experimental Dermatology

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An adequate knowledge on molecular mechanism of melanogenesis provides an opportunity to find the novel molecular targets for the discovery and development of new cosmetics. Among various genes, the OCA2 is being essential for proper melanin synthesis, and mutation or deletion of this gene leads to oculocutaneous albinism type 2. Thus, for this study, the product of this gene, that is P-protein, was targeted in quest for novel inhibitors as antimelanogenic agents. Based on pattern search of amino acid sequence and homology analysis, the protein structure was modelled. The role of this protein has been predicted as a tyrosine transporter of melanosomes. Thus, the molecular library was generated on the basis of tyrosine transporter inhibitor. Based on the dock score, 20 molecules have been considered as putative inhibitors for P-protein. Among these compounds, five molecules (compound #1, #4, #8, #13 and #17) were found to be quite effective as antimelanogenic without having any toxicity. Further investigations to establish the mechanism of action, the indirect methods such as tyrosinase assay, analysis for eumelanin and pheomelanins and investigation of mRNA levels were being carried out. The results from the studies offered a new lead in antimelanogenic therapy and may be very useful for further optimization work in developing them as novel depigmenting agents.

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“…기능성 화장품에서 미백소재 개발 연구는 tyrosinase의 저해활성뿐만 아니라 멜라닌 생성과정에 관 여하는 각종 효소의 저해 활성, 이와 관련이 있는 유전 자 발현과 멜라닌 생성을 세포 수준에서 관찰하고 인 체 시험을 통해서 평가 확인하는 과정을 거친다. 최근 에는 천연물을 이용한 미백 효능뿐만 아니라 주름개선 등 항노화 효능을 함께 갖는 복합 기능성 소재 개발에 도 많은 관심이 모아지고 있다 [16].…”

Section: 서 론unclassified

Anti-inflammatory and Whitening Effects of Protaetia brevitarsis Seulensis Extracts by Oriental Conversion Methods

Sung¹,

Kim²,

Park³

2016

Journal of the Society of Cosmetic Scientists of Korea

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Abstract:In order to find new functional materials for the cosmetics application, we investigated anti-inflammatory and whitening effects of the Protaetia brevitarsis seulensis (P. brevitarsis) extracts, which were prepared by the various oriental conversion methods, as follows; fresh, roasted one time, roasted two times, roasted three times, and steamed. 2,2-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities of the various solvent extracts (80% ethanol, 50% ethanol, ethyl acetate, hexane) of P. brevitarsis extracts were 85.5, 22.4, 37.0 and 19.4% respectively. The 80% ethanol

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Depigmenting effect of Cinnamomum cassia Presl in B16F10 melanoma cells

Cited by 16 publications

References 15 publications

Effect of Fomitopsis pinicola extract on blood glucose and lipid metabolism in diabetic rats

Effect of Fomitopsis pinicola extract on blood glucose and lipid metabolism in diabetic rats

Homology modelling and virtual screening of P‐protein in a quest for novel antimelanogenic agent and In vitro assessments

Anti-inflammatory and Whitening Effects of Protaetia brevitarsis Seulensis Extracts by Oriental Conversion Methods

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