Dependence of the phase separation process on the relative onset of network formation in simultaneous interpenetrating polymer networks

Widmaier, Jean‐Michel; Nilly, Alexandra; Chenal, Jean-Marc; Mathis, A.

doi:10.1016/j.polymer.2005.02.082

Cited by 25 publications

(28 citation statements)

References 9 publications

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“…Each is expected to produce different morphologies and as a consequence a specifi c set of physical and mechanical properties [88] . Studies were carried out on polyurethane -polymethyl methacrylate SIN [89] to determine how morphology develops from the initial mixture to the fi nal IPN. This was done by starting the polymerization of MMA at various degrees of polymerization of PU, especially in the PU pre -gel region.…”

Section: Synthesis and Property Achievements Simultaneous Interpenetrmentioning

confidence: 99%

Basic Features and Techniques

Bhattacharya

Ray

2008

Polymer Grafting and Crosslinking

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Section: Synthesis and Property Achievements Simultaneous Interpenetrmentioning

confidence: 99%

Basic Features and Techniques

Bhattacharya

Ray

2008

Polymer Grafting and Crosslinking

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“…17 However, very often these hydrogels have weak mechanical properties which might be related to imperfect cross-linking of polymer chains which starts right after mixing of the reactive polymer precursors. 21,25 One can envisage that the combination of two cross-linking processes may still affect each other due to steric hindrances imposed by the partially formed networks. 18,19 The formation of interpenetrating networks (IPNs) or double networks 20 is an effective method to improve the mechanical strength of hydrogels.…”

Section: Introductionmentioning

confidence: 99%

“…Mechanical integrity is one of the most important properties of hydrogels in many tissue engineering applications, especially in bone regeneration. 3,[25][26][27] Most of the double network hydrogels were prepared sequentially, and they exhibited better mechanical properties than the corresponding single network hydrogels. [20][21][22] From a synthetic viewpoint, IPNs can be classified into two main groups: sequential IPNs and in situ IPNs.…”

Section: Introductionmentioning

confidence: 99%

“…18,19 The formation of interpenetrating networks (IPNs) or double networks 20 is an effective method to improve the mechanical strength of hydrogels. 3,25 In this work, we, for the first time, pursued in situ formation of bio-compatible IPN hydrogels by two simultaneous chemoselective cross-linking reactions. In the former case, a first network is prepared and swollen in a solution containing precursors for a second network which is then formed within the first network.…”

Section: Introductionmentioning

confidence: 99%

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In situ forming interpenetrating hydrogels of hyaluronic acid hybridized with iron oxide nanoparticles

et al. 2015

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Four derivatives of hyaluronic acid (HA) bearing thiol (HA-SH), hydrazide (HA-hy), 2-dithiopyridyl (HA-SSPy), and aldehyde groups (HA-al) respectively were synthesized. Thiol and 2-dithiopyridyl as well as hydrazide and aldehyde make up two chemically orthogonal pairs of chemo-selective functionalities that allow in situ formation of interpenetrating (IPN) disulfide and hydrazone networks simultaneously upon the mixing of the above derivatives at once. The formation of IPN was demonstrated by comparing it with the formulations of the same total HA concentration but lacking one of the reactive components. The hydrogel composed of all four components was characterized by a larger elastic modulus than those of the control single networks (either disulfide or hydrazone) and the three component formulations gave the softest hydrogels. Moreover, a hydrazone cross-linkage was designed to contain a 1,2-diol fragment. This allowed us to partially disassemble one type of network in the IPN leaving another one unaffected. In particular, treatment of the IPN with either sodium periodate or dithiothreitol resulted in disassembly of the hydrazone and disulfide networks respectively and thus softening of the hydrogel. Contrarily, the single network hydrogels completely dissolved under the corresponding conditions. In corroboration with this, enzymatic degradation of the IPN by hyaluronidase was also substantially slower than the degradation of the single networks. In order to further improve the mechanical properties of the elaborated injectable IPN, it has been in situ hybridized with iron oxide nanoparticles (IONPs). The mesh size of the IPN was smaller than the size of the IONPs resulting in the retention of nanoparticles in the matrix under equilibrium swelling conditions. However, these nanoparticles were released upon enzymatic degradation suggesting their use as MRI tags for non-invasive tracking of the hydrogel material in vivo. Additionally, this injectable hybridized hydrogel with encapsulated IONPs can be used in hyperthermia cancer therapy.

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“…The dependence of the phase separation process on the relative onset of network formation in simultaneous IPNs was studied in [304]. The morphology development during synthesis at room temperature of a PU/PMMA IPN was investigated by SAXS in relation to their relative kinetics of formation, determined by FTIR spectroscopy.…”

Section: Kinetics Of Formation Of Sequential Ipnsmentioning

confidence: 99%