Dependence of adolescent novelty-seeking behavior on response phenotype and effects of apparatus scaling.

Philpot, Rex M.; Wecker, Lynn

doi:10.1037/0735-7044.122.4.861

Cited by 41 publications

(45 citation statements)

References 65 publications

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“…Animal data coheres with the human literature given adolescent-limited increases in novelty preference, exploration, and risk-taking (Douglas et al 2003; Spear, 2000; Stansfield & Kirstein, 2006), effects that are enhanced by individual dispositions as well as environmental stress (Philpot & Wecker, 2008; Toledo-Rodriguez & Sandi, 2011). In addition, adolescent rats show increased levels of incentive learning relative to adults (Burton, Noble & Fletcher, 2011).…”

Section: Evidence For Increased Incentive Motivation In Adolescencesupporting

confidence: 70%

Dopaminergic modulation of incentive motivation in adolescence: Age-related changes in signaling, individual differences, and implications for the development of self-regulation.

Luciana¹,

Wahlstrom²,

Porter³

et al. 2012

Developmental Psychology

122

126

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Behavioral activation that is associated with incentive-reward motivation increases in adolescence relative to childhood and adulthood. This quadratic developmental pattern is generally supported by behavioral and experimental neuroscience findings. We suggest that a focus on changes in dopamine neurotransmission is informative in understanding the mechanism for this adolescent increase in reward-related behavioral activation and subsequent decline into adulthood. We present evidence to indicate that incentive-reward motivation is modulated by mesoaccumbens dopamine and that it increases in adolescence before declining into adulthood due to normative developmental changes at the molecular level. Potential mechanisms of variation in functional mesoaccumbens dopamine transmission are discussed with a focus on the interplay between tonic and phasic modes of DA transmission in modulating both general incentive-motivational biases and the efficacy of reward learning during exposure to novel reward experiences. Interactions between individual difference factors and these age-related trends are discussed.

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Section: Evidence For Increased Incentive Motivation In Adolescencesupporting

confidence: 70%

Dopaminergic modulation of incentive motivation in adolescence: Age-related changes in signaling, individual differences, and implications for the development of self-regulation.

Luciana¹,

Wahlstrom²,

Porter³

et al. 2012

Developmental Psychology

122

126

View full text Add to dashboard Cite

show abstract

“…High responders also showed increased sensitivity to the reinforcing effects of psychostimulants as measured by acquisition of amphetamine self-administration, suggesting a relationship between the sensation seeking trait and the development of substance use behaviors. When compared to young adult rats, adolescents exhibited more sensation seeking behaviors (Philpot & Wecker, 2008). Gipson et al (2012) developed a translational behavioral model of negative urgency to be used in both humans and rats.…”

Section: Review Of Impulsive Behavior and Drug Use In Adolescence mentioning

confidence: 99%

Age and impulsive behavior in drug addiction: A review of past research and future directions

Argyriou

Carron

et al. 2018

Pharmacology Biochemistry and Behavior

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Impulsive behavior is implicated in the initiation, maintenance, and relapse of drug-seeking behaviors involved in drug addiction. Research shows that changes in impulsive behavior across the lifespan contribute to drug use and addiction. The goal of this review is to examine existing research on the relationship between impulsive behavior and drug use across the lifespan and to recommend directions for future research. Three domains of impulsive behavior are explored in this review: impulsive behavior-related personality traits, delay discounting, and prepotent response inhibition. First, we present previous research on these three domains of impulsive behavior and drug use across developmental stages. Then, we discuss how changes in impulsive behavior across the lifespan are implicated in the progression of drug use and addiction. Finally, we discuss the relatively limited attention given to middle-to-older adults in the current literature, consider the validity of the measures used to assess impulsive behavior in middle-to-older adulthood, and suggest recommendations for future research.

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“…They additionally have been found to engage in higher overall levels of social behavior than adults, while displaying a different pattern of social interactions that emphasizes play, rather than more adult-typical social investigation (e.g., Vanderschuren et al, 1997; Varlinskaya and Spear, 2002; 2008). Adolescent rodents also exhibit enhanced novelty seeking (Adriani et al, 1998; Philpot and Wecker, 2008; Stansfield and Kirstein, 2006) relative to their more mature counterparts. The incidence of such behaviors may be especially high during adolescence because adolescents find these stimuli to be particularly reinforcing.…”

Section: Adolescent Sensitivity To Rewardsmentioning

confidence: 99%

Reward-centricity and attenuated aversions: An adolescent phenotype emerging from studies in laboratory animals

Doremus-Fitzwater

Spear

2016

Neuroscience & Biobehavioral Reviews

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Adolescence is an evolutionarily conserved developmental period, with neural circuits and behaviors contributing to the detection, procurement, and receipt of rewards bearing similarity across species. Studies with laboratory animals suggest that adolescence is typified by a “reward-centric” phenotype—an increased sensitivity to rewards relative to adults. In contrast, adolescent rodents are reportedly less sensitive to the aversive properties of many drugs and naturally aversive stimuli. Alterations within the mesocorticolimbic dopamine and endocannabinoid systems likely contribute to an adolescent reward-sensitive, yet aversion-resistant, phenotype. Although early hypotheses postulated that developmental changes in dopaminergic circuitry would result in a “reward deficiency” syndrome, evidence now suggests the opposite: that adolescents are uniquely poised to seek out hedonic stimuli, experience greater “pleasure” from rewards, and consume rewarding stimuli in excess. Future studies that more clearly define the role of specific brain regions and neurotransmitter systems in the expression of behaviors toward reward- and aversive-related cues and stimuli are necessary to more fully understand an adolescent-proclivity for and vulnerability to rewards and drugs of potential abuse.

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Dependence of adolescent novelty-seeking behavior on response phenotype and effects of apparatus scaling.

Cited by 41 publications

References 65 publications

Dopaminergic modulation of incentive motivation in adolescence: Age-related changes in signaling, individual differences, and implications for the development of self-regulation.

Dopaminergic modulation of incentive motivation in adolescence: Age-related changes in signaling, individual differences, and implications for the development of self-regulation.

Age and impulsive behavior in drug addiction: A review of past research and future directions

Reward-centricity and attenuated aversions: An adolescent phenotype emerging from studies in laboratory animals

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