Deoxyspergualin in Lethal Murine Graft-Versus-Host Disease

15-deoxyspergualin prevents mucosal injury by inhibiting production of TNF-α and down-regulating expression of MD-1 in a murine model of TNBS-induced colitis

“…Several studies provided clear evidence for the powerful immunosuppressive properties of DSG in experimental models of auto-, allo-and xenoimmunity [13,31]. In agreement with these experimental observations, clinical studies in human have demonstrated that DSG reverse kidney [32,33] and liver [34] allograft rejection.…”

Graft-versus-Host Disease in Bone Marrow Transplantation: Experimental, Laboratory, and Clinical Contributions of the Last Few Years

“…New immunosuppressive agents or other types of anti-GVHD therapies which have been found to effectively counteract GVHD in animal models include the following: rapamycin [41], deoxyspergualin [42], anti-T cell ricin toxin A chain immunotoxin [43], FK506 [44], RS-61443 [45], DL-a-difluoromethylornithine [46], succinyl acetone [47], and estradiol-chlorambucil conjugate (KM2210) [48], Differential Modification o f T Cell Subpopulations. Mu rine studies suggest that GVHD and the engraftment-promoting and/or antileukemic effects of allogeneic BM cells are mediated by different cells or T cell subpopulations.…”

Evaluation of the ameliorative effects of immunosuppressants on crescentic glomerulonephritis in SCG/Kj mice

“…DSG is an analogue of spergualin [6] isolated from culture filtrate of Bacillus laterosporus, and bears a moiety of spermidine and a guanidinic group. DSG has been found to suppress humoral and cell-mediated immune responses [7][8][9][10][11][12][13]. Although the mechanism behind the DSGmediated immunosuppression is still not unraveled, it is known that DSG binds to a member of the heat shock protein 70 family and may inhibit the translocation of nuclear factor NF-κB and the expression of MHC class II antigens [14][15][16][17].…”