Deoxyribonucleic Acid Ploidy and the Direct Assay of Prostatic Acid Phosphatase and Prostate Specific Antigen in Fine Needle Aspiration Biopsies as Diagnostic Methods in Prostatic Carcinoma

Stege, Reinhard; Lundh, B.; Tribukait, Bernhard; Pousette, Åke; Carlström, Kjell; Hasenson, Michael

doi:10.1016/s0022-5347(17)39436-3

Cited by 35 publications

(28 citation statements)

References 14 publications

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“…Qiu and associates (Qiu et al, 1990) demonstrated a significant decrease in PSA mRNA expression in carcinoma tissue when compared with benign prostatic epithelium. Reduced PSA concentrations have also been found in carcinoma tissue by biochemical methods (Stege et al, 1990;Pretlow et al, 1991;Stege et al, 1992). This is in agreement with our findings.…”

Section: Gradesupporting

confidence: 93%

Hormone resistant prostatic adenocarcinoma. An evaluation of prognostic factors in pre- and post-treatment specimens

Berner

Nesland²,

Wæhre³

et al. 1993

Br J Cancer

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Pre- and post-treatment specimens from 47 patients with hormone resistant prostatic carcinoma were compared with each other regarding histological grade and immunoreactivity for p53 protein, neuron specific enolase and c-erbB-2 protein. Significantly more specimens expressed a high malignancy grade when the tumour had become hormone resistant than at the time of initial diagnosis (Gleason P: < 0.0001, WHO P:0.0003). p53 protein immunoreactivity increased significantly with disease progression (P:0.006), while tissue PSA immunoreactivity was reduced in post-treatment specimens (P:0.011). p53 protein expression did not correlate with histological grade or PSA expression and seems to be an independent parameter which participates late in the neoplastic transformation. Thirty-two percent of the tumours were neuron specific enolase positive, but this parameter did not correlate with development of hormone resistance. c-erbB-2 protein reactivity was not recognised. Images Figure 1

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Section: Gradesupporting

confidence: 93%

Hormone resistant prostatic adenocarcinoma. An evaluation of prognostic factors in pre- and post-treatment specimens

Berner

Nesland²,

Wæhre³

et al. 1993

Br J Cancer

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“…This has also been described in biochemical investigations (11)(12)(13). In a prospective study of 179 hormonally treated patients with prostate carcinoma, tissue PSA was the dominating prognostic factor.…”

Section: Discussionmentioning

confidence: 56%

“…ment membrane in high-grade lesions is observed frequently and is important for the decrease in tissue PSA. This is supported by biochemical studies of tissue and S-PSA in which an inverse relationship between them was observed (11). However, lower levels of mRNA in malignant tissues of the prostate have also been described (15,16), indicating that the production of tissue PSA can be decreased.…”

Section: Discussionmentioning

confidence: 73%

“…A decrease in tissue PSA was related significantly to an increase in tumor stage, grade, and to the shift from a diploid to an aneuploid DNA pattern. With the decrease in tissue PSA, S-PSA increased significantly (11). A low level of tissue PSA was associated with poor prognosis in hormonally treated patients (12,13).…”

mentioning

confidence: 90%

“…Cytosolic tissue PSA has been quantified by the RIA technique from fine-needle aspiration biopsies of patients with benign and malignant lesions (11)(12)(13). A decrease in tissue PSA was related significantly to an increase in tumor stage, grade, and to the shift from a diploid to an aneuploid DNA pattern.…”

mentioning

confidence: 99%

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Double‐fluorescence image microscopy for quantitation of prostate‐specific antigen in histologic sections of the prostate

Wang¹,

Tribukait²

2002

Cytometry

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Correlation of DNA ploidy and histologic diagnosis from prostate core-needle biopsies: Is DNA ploidy more sensitive than histology for the diagnosis of carcinoma in small specimens?

Kerns

Amling

et al. 1996

J. Surg. Oncol.

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Deoxyribonucleic Acid Ploidy and the Direct Assay of Prostatic Acid Phosphatase and Prostate Specific Antigen in Fine Needle Aspiration Biopsies as Diagnostic Methods in Prostatic Carcinoma

Cited by 35 publications

References 14 publications

Hormone resistant prostatic adenocarcinoma. An evaluation of prognostic factors in pre- and post-treatment specimens

Hormone resistant prostatic adenocarcinoma. An evaluation of prognostic factors in pre- and post-treatment specimens

Double‐fluorescence image microscopy for quantitation of prostate‐specific antigen in histologic sections of the prostate

Correlation of DNA ploidy and histologic diagnosis from prostate core-needle biopsies: Is DNA ploidy more sensitive than histology for the diagnosis of carcinoma in small specimens?

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