Deoxyribonucleic Acid (DNA) Ploidy and Proliferative Characteristics of Metastatic Squamous Cell Carcinoma Determined by Flow Cytometric Analysis

Pappas, Alex A.; Maners, Ann; Owens, Rebecca; Thompson, Jeffrey P.; King, John C.; Dinehart, Scott M.

doi:10.1111/j.1524-4725.1992.tb02767.x

Cited by 6 publications

(1 citation statement)

References 8 publications

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“…All tumors analyzed in this study showed the average percentage of cells in S phase of cell cycle increased in relation to normal skin. Associated with aneuploidy, the proliferative index, the rate of cells in S phase is another possible indicator of prognosis of the biological aggressiveness of solid tumors [23]. DNA aneuploidy or tetraploidy and histology of well differentiated squamous cell carcinoma were significantly associated with metastasis to regional lymph nodes [24].…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors correlation between the cell cycle phases and apoptosis in basal cell carcinoma

Festa-Neto¹,

Maria

2011

OJIM

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Basal cell carcinoma (BCC) is the most common skin malignancy, are found in various forms depending on their clinical and biological behavior. The objective of study was analyzed the phases of the cell cycle and correlations between BCC of low and high risk of recurrence and correlation prognostic factors. The quantity of content DNA in tissues of normal skin, showed small amount of cells in apoptosis and mostly in phase quiescent and rare aneuploidy cells. In BCC, apoptosis was higher in the BCC at high risk than low risk, probably due to their high rates of cell proliferation, and present of aneuploidy cells, when compared to the average percentage of aneuploidy. The DNA content from cells of normal skin shows that the majority is in the quiescent phase; compatible with tissues that are is refreshing. There is presence of apoptosis in the epidermis by probable normal process of differentiation. The aneuploidy in BCC showed a direct correlation with the degree of tumor aggressiveness

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Section: Discussionmentioning

confidence: 99%

Prognostic factors correlation between the cell cycle phases and apoptosis in basal cell carcinoma

Festa-Neto¹,

Maria

2011

OJIM

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DNA ploidy in nonmelanoma skin cancer

Robinson

Rademaker

Goolsby

et al. 1996

Cancer

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The measurement of DNA ploidy of well differentiated squamous cell carcinoma, and proliferative capacity or S-phase of both basal cell and squamous cell carcinomas assists in predicting the biologic proclivity for locoregional invasion or metastasis of nonmelanoma skin cancer. Identification of aggressive tumors at the time of surgery may offer the opportunity for prevention of lethal metastasis by using adjunctive therapy.

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Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis

Dinehart

Nelson‐Adesokan

Cockerell

et al. 1997

Cancer

101

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Deoxyribonucleic Acid (DNA) Ploidy and Proliferative Characteristics of Metastatic Squamous Cell Carcinoma Determined by Flow Cytometric Analysis

Abstract: We conclude that aneuploidy and S-phase fraction by fluorescent activated cytometry are not significant predictors of potential metastases in cutaneous squamous cell carcinoma.

Cited by 6 publications

References 8 publications

Prognostic factors correlation between the cell cycle phases and apoptosis in basal cell carcinoma

Prognostic factors correlation between the cell cycle phases and apoptosis in basal cell carcinoma

DNA ploidy in nonmelanoma skin cancer

Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis

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