Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis

Dinehart, Scott M.; Nelson‐Adesokan, Paula; Cockerell, Clay J.; Russell, Shelly; Brown, Robert O.

doi:10.1002/(sici)1097-0142(19970301)79:5<920::aid-cncr8>3.0.co;2-f

Cited by 101 publications

(60 citation statements)

References 19 publications

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“…AK has been hypothesized to be a precursor of SCC. 50 Treatments for AK vary from external topical medication to surgery, while SCC and BCC are almost always removed surgically. A combination of three PCs (D2, L2, and R9) resulted in the best classification between SCCBCC (biopsy and surgical excision) versus AK (cryotherapy/topical cream treatment), providing sensitivity/specificity of 95%/71%.…”

Section: Nonmelanoma Skin Cancermentioning

confidence: 99%

Clinical study of noninvasivein vivomelanoma and nonmelanoma skin cancers using multimodal spectral diagnosis

et al. 2014

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Abstract. The goal of this study was to determine the diagnostic capability of a multimodal spectral diagnosis (SD) for in vivo noninvasive disease diagnosis of melanoma and nonmelanoma skin cancers. We acquired reflectance, fluorescence, and Raman spectra from 137 lesions in 76 patients using custom-built optical fiber-based clinical systems. Biopsies of lesions were classified using standard histopathology as malignant melanoma (MM), nonmelanoma pigmented lesion (PL), basal cell carcinoma (BCC), actinic keratosis (AK), and squamous cell carcinoma (SCC). Spectral data were analyzed using principal component analysis. Using multiple diagnostically relevant principal components, we built leave-one-out logistic regression classifiers. Classification results were compared with histopathology of the lesion. Sensitivity/specificity for classifying MM versus PL (12 versus 17 lesions) was 100%/100%, for SCC and BCC versus AK (57 versus 14 lesions) was 95%/71%, and for AK and SCC and BCC versus normal skin (71 versus 71 lesions) was 90%/85%. The best classification for nonmelanoma skin cancers required multiple modalities; however, the best melanoma classification occurred with Raman spectroscopy alone. The high diagnostic accuracy for classifying both melanoma and nonmelanoma skin cancer lesions demonstrates the potential for SD as a clinical diagnostic device.

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Section: Nonmelanoma Skin Cancermentioning

confidence: 99%

Clinical study of noninvasivein vivomelanoma and nonmelanoma skin cancers using multimodal spectral diagnosis

et al. 2014

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“…A third, moderately-differentiated subtype of SCCI shares the features of both welldifferentiated and poor-differentiated tumors (Yanofsky et al, 2011). It is thought that poorly differentiated tumors have a higher rate of metastasis (Dinehart et al, 1997;Dinehart & Pollack, 1989;Lund et al, 1984). Another essential component in assessing the malignant potential of a tumor is the presence of perineural and perivascular spread.…”

Section: Squamous Cell Carcinoma (Scc)mentioning

confidence: 99%

Malignant Transformation in Skin is Associated with the Loss of T-Cadherin Expression in Human Keratinocytes and Heterogeneity in T-Cadherin Expression in Tumor Vasculature

Рубина¹,

Sysoeva²,

Semina³

et al. 2012

Tumor Angiogenesis

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“…In einer amerikanischen Studie konnte in 97% von 459 untersuchten SCC eine Assoziation mit unmittelbar benachbart liegenden AK dargestellt werden [14]. Dinehart et al beschrieben AK in der Nachbarschaft von 44% aller untersuchten metastasierten SCC [5].Insgesamt ist eine steigende Inzidenz von AK und SCC zu verzeichnen, wobei das theoretisches Risiko der Ausbildung eines invasiven SCC aus AK innerhalb von 10 Jahren zwischen 0,025% und 16% liegt [7,13,21,26].…”

Section: Diskussionunclassified

Die aktinische Keratose

2003

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Actinic keratoses are defined as proliferation of cytologically atypical keratinocytes in the zone of epidermal-dermal junction in photodamaged skin. In the northern hemisphere the prevalence of actinic keratoses ranges depending on different epidemiological studies from 11% to 25% for people aged 40 or older. The main cause of actinic keratoses is exposure to UVB radiation in sunlight UVB radiation induces mutations in the telomerase gene and in the tumor suppressor gene P53, which can also be detected in invasive squamous cell carcinoma. The only histological parameter to distinguish between actinic keratoses and SCC is the level of invasiveness. The risk for actinic keratoses to develop into SCC is about 16% over lo years. For this reason and because of the high prevalence of actinic keratoses, it has been suggested to replace the term,, actinic keratosis K with intraepidermal squamous cell carcinoma' to better characterize the lesion. In the following review recent aspects of pathogenesis and therapy of actinic keratoses are discussed.

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Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis

Cited by 101 publications

References 19 publications

Clinical study of noninvasivein vivomelanoma and nonmelanoma skin cancers using multimodal spectral diagnosis

Clinical study of noninvasivein vivomelanoma and nonmelanoma skin cancers using multimodal spectral diagnosis

Malignant Transformation in Skin is Associated with the Loss of T-Cadherin Expression in Human Keratinocytes and Heterogeneity in T-Cadherin Expression in Tumor Vasculature

Die aktinische Keratose

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