Deoxynivalenol triggers porcine intestinal tight junction disorder: Insights from mitochondrial dynamics and mitophagy

Protective Effects of Astaxanthin on Ochratoxin A-Induced Liver Injury: Effects of Endoplasmic Reticulum Stress and Mitochondrial Fission–Fusion Balance

“…Mitochondrial division is primarily regulated by DRP1 and MFF, and excessive mitochondrial division reduces mitochondrial oxidative phosphorylation and ATP content, damaging mitochondrial structure and function [ 50 ]. Studies have revealed that, in pig intestinal epithelial cells, deoxynivalenol can upregulate the genetic expressions of mitochondrial division factors DRP1 and MFF, downregulate the expressions of two mitochondrial fusion proteins, MFN1 and MFN2, disrupt the balance of mitochondrial division and fusion, cause mitochondrial morphological and functional damage, and induce a mitochondrial dynamics imbalance [ 51 ]. T-2 toxins cause mitochondrial morphological and functional damage by upregulating the expression of the mitochondrial division factor DRP1 and downregulating the expression of the mitochondrial fusion proteins OPA1, MFN1, and MFN2 in human liver 7702 cells [ 52 ].…”

Establishment of a chicken intestinal organoid culture system to assess deoxynivalenol-induced damage of the intestinal barrier function

“…Furthermore, the gut epithelium is comprised of rapidly dividing cells with a high protein turnover rate, which is the primary target of DON [ 24 ]. Many reports have demonstrated the DON-induced damage to the reduction of the tight junction proteins via intestinal epithelial cell lines [ 25 – 27 ]. Research regarding DON-induced dysfunction in the small intestine is not complete, and thus, we have developed a stable chicken small intestinal organoid culture system to elucidate DON’s effect on the chicken small intestine.…”

A nivalenol imprinted quartz crystal microbalance sensor based on sulphur-incorporating cobalt ferrite and its application to rice samples

“…9,10 In addition, NIV has been reported to have health effects such as hematologic problems, genotoxic, leukopenia, immunosuppressive and immunomodulatory. 11–13 Due to these adverse effects, some authorities have set maximum NIV levels in various nutrients to ensure both public health and agricultural productivity 14 and the tolerable daily intake for NIV in various nutrients and feeds is reported as 1.2 mg per kg per day. 15 Thus, the detection of NIV in foods is significant and various analysis methods such as chromatographic techniques and immunochemical-based methods are available in the literature.…”