Deoxycholic acid-stimulated macrophage-derived exosomes promote spasmolytic polypeptide-expressing metaplasia in the stomach

Xu, Xiaoquan; Cheng, Jinnian; Luo, Shengzheng; Gong, Xiaoyuan; Huang, Dan; Xu, Jingxian; Qian, Yueqin; Wan, Xinjian; Zhou, Hui

doi:10.1016/j.bbrc.2020.01.159

Cited by 16 publications

(11 citation statements)

References 29 publications

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Section: Immunomodulatory Effects Of Mφ-evs In Chronic Inflammatory Diseasementioning

confidence: 99%

“…Chronic inflammation influences the development of spasmolytic polypeptide-expressing metaplasia (171), and deoxycholic acid (DCA) enhances the expression of enteral metaplasia markers (172). Xu et al cocultured mouse stomachic organoids with DCA treated macrophage-derived EVs(DCA-Mj-EVs), and the data revealed that the expression of SPEM marker proteins TFF2, GSII, SPEM-related cistron Wfdc2, Olfm4 and Cftr were considerably inflated when 72h cocultured (172).…”

Section: Gastrointestinal Diseasementioning

confidence: 99%

Section: Gastrointestinal Diseasementioning

confidence: 99%

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The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases

et al. 2021

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As natural nanocarriers and intercellular messengers, extracellular vesicles (EVs) control communication among cells. Under physiological and pathological conditions, EVs deliver generic information including proteins and nucleic acids to recipient cells and exert regulatory effects. Macrophages help mediate immune responses, and macrophage-derived EVs may play immunomodulatory roles in the progression of chronic inflammatory diseases. Furthermore, EVs derived from various macrophage phenotypes have different biological functions. In this review, we describe the pathophysiological significance of macrophage-derived extracellular vesicles in the development of chronic inflammatory diseases, including diabetes, cancer, cardiovascular disease, pulmonary disease, and gastrointestinal disease, and the potential applications of these EVs.

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Section: Immunomodulatory Effects Of Mφ-evs In Chronic Inflammatory Diseasementioning

confidence: 99%

Section: Gastrointestinal Diseasementioning

confidence: 99%

Section: Gastrointestinal Diseasementioning

confidence: 99%

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The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases

et al. 2021

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“…Macrophages may be involved in this inflammatory process. Xu et al reported that Deoxycholic acid-stimulated exosomes secreted by macrophages promote cellular communication between macrophages and gastric epithelial cells, thus facilitating development of SPEM, however, the study did not elucidate the mechanism (Xu et al, 2020). Macrophages are implicated in pathogenesis of kidney stones as they are involved in the immune response through the exosomal pathway after exposure to calcium hydroxalate (COM) crystal crystals.…”

Section: Other Diseasesmentioning

confidence: 98%

The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes

Shan

Zhang

Mai

et al. 2021

Front. Mol. Biosci.

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Macrophage-derived exosomes have been implicated on the modulation of inflammatory processes. Recent studies have shown that macrophage-derived exosomes contribute to the progression of many diseases such as cancer, atherosclerosis, diabetes and heart failure. This review describes the biogenesis of macrophage-derived exosomes and their biological functions in different diseases. In addition, the challenges facing the use of macrophage-derived exosomes as delivery tools for drugs, genes, and proteins in clinical applications are described. The application of macrophage-derived exosomes in the diagnosis and treatment of diseases is also discussed.

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“…SPEM is an important risk factor driven by macrophage-mediated chronic inflammation. It is demonstrated that exosomes derived from the macrophage induced by deoxycholic acid (a type of harmful secondary bile acid) increased the expression of SPEM markers (TFF2 and GSII lectin) in gastric organoids, indicating the role of macrophage-derived exosomes in the onsets of GC [123]. Zheng et al (2017) showed that tumor-associated macrophage (TAM)-derived exosome enriched with miRNA-21 down-regulates PTEN, suppresses cell apoptosis, and enhances the activation of PI3K/AKT signaling pathway [124].…”

Section: Role Of Exosomes In Gastric Cancermentioning

confidence: 99%

Helicobacter pylori-Induced Inflammation: Possible Factors Modulating the Risk of Gastric Cancer

2021

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Chronic inflammation and long-term tissue injury are related to many malignancies, including gastric cancer (GC). Helicobacter pylori (H. pylori), classified as a class I carcinogen, induces chronic superficial gastritis followed by gastric carcinogenesis. Despite a high prevalence of H. pylori infection, only about 1–3% of people infected with this bacterium develop GC worldwide. Furthermore, the development of chronic gastritis in some, but not all, H. pylori-infected subjects remains unexplained. These conflicting findings indicate that clinical outcomes of aggressive inflammation (atrophic gastritis) to gastric carcinogenesis are influenced by several other factors (in addition to H. pylori infection), such as gut microbiota, co-existence of intestinal helminths, dietary habits, and host genetic factors. This review has five goals: (1) to assess our current understanding of the process of H. pylori-triggered inflammation and gastric precursor lesions; (2) to present a hypothesis on risk modulation by the gut microbiota and infestation with intestinal helminths; (3) to identify the dietary behavior of the people at risk of GC; (4) to check the inflammation-related genetic polymorphisms and role of exosomes together with other factors as initiators of precancerous lesions and gastric carcinoma; and (5) finally, to conclude and suggest a new direction for future research.

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Deoxycholic acid-stimulated macrophage-derived exosomes promote spasmolytic polypeptide-expressing metaplasia in the stomach

Cited by 16 publications

References 29 publications

The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases

The Immuno-Modulation Effect of Macrophage-Derived Extracellular Vesicles in Chronic Inflammatory Diseases

The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes

Helicobacter pylori-Induced Inflammation: Possible Factors Modulating the Risk of Gastric Cancer

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