Denture cream

Nations, Sharon P.; Boyer, Philip J.; Love, Lori A.; Burritt, Mary F.; Butz, John A.; Wolfe, Gil I.; Hynan, Linda S.; Reisch, Joan; Trivedi, Jaya

doi:10.1212/01.wnl.0000312375.79881.94

Cited by 178 publications

(119 citation statements)

References 31 publications

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“…He admitted to using three 40 g tubes of zinccontaining denture adhesives per week, a selection of which were found to contain 17-34 mg of zinc per gram. 2 Although the patient did admit to swallowing some of 'swayback' for many years, 6 but has only recently been recognised in humans, and even more recently the role of zinc containing adhesives has been described in several case reports. 1,2 While evidence remains at case report level and without being able to exactly determine the amount of ingested denture adhesive/absorbed zinc, the relationship between copper deficient myelopathy and zinc-containing denture adhesive remains a hypothesis.…”

Section: How Does Zinc Excess Results In Copper Deficiency?mentioning

confidence: 99%

“…1,2,8,11 Prevention is therefore essential and dentists have an important role in educating patients about denture adhesive use. Dentists are well placed to identify patients who may be using zinccontaining denture adhesives to excess and who have anaemia or neurological symptoms affecting balance and walking.…”

Section: How Does Zinc Excess Results In Copper Deficiency?mentioning

confidence: 99%

“…1,2 As this condition is preventable but largely untreatable, dentists are well placed to detect denture adhesive overuse in patients with neurological symptoms and anaemia, and prompt further investigation.…”

Section: Introductionmentioning

confidence: 99%

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Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy

2011

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Section: How Does Zinc Excess Results In Copper Deficiency?mentioning

confidence: 99%

Section: How Does Zinc Excess Results In Copper Deficiency?mentioning

confidence: 99%

See 1 more Smart Citation

Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy

2011

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“…3 Treatment with copper supplementation stops further deterioration, but recovery is minimal and often subjective whereas the haematological abnormalities promptly resolve. 3,4,6 Zinc induces the expression of intracellular metallothionein, a chelator in the gut enterocytes. Copper has a higher affinity for metallothionein than zinc and will therefore displace any bound zinc, and will be lost in the faeces when the enterocyte is sloughed off.…”

Section: Resultsmentioning

confidence: 99%

Zinc poisoning from excessive denture fixative use masquerading as myelopolyneuropathy and hypocupraemia

Barton

Fisher²,

Smith

2011

Ann Clin Biochem

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A 50-year-old man presented with a four-year history of unsteadiness, with recent falls and tingling in his fingers. Neurological examination found an ataxic gait, with a positive Romberg's sign. There was distal wasting and weakness in all four limbs and impaired co-ordination, with pseudoathetosis in the arms. Initial investigations showed a normochromic, normocytic anaemia, leucopenia, neutropenia and a low vitamin B 12 (172 ng/L). Treatment with intramuscular cobalamin injections showed no clinical improvement. Further investigations showed an undetectable caeruloplasmin (,0.085 g/L), a very low serum copper (1.1 mmol/L) and a markedly raised serum zinc concentration (36.2 mmol/L). On detailed questioning it became apparent that he had ill-fitting dentures requiring excessive use of denture fixative with high zinc content. The patient was switched to a non-zinc containing denture fixative and commenced copper supplementation. Although within three months the bone marrow suppression had resolved, there was no clinical improvement in neurological presentation. Questioning a patient about their denture fixative usage and checking if zinc is an ingredient may be considered during an investigation for myelopolyneuropathy when vitamin B 12 deficiency is not a cause.

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“…Adhesive ingredients that improve denture support can include a blend of polymer salts, calcium salts and zinc for soluble adhesives and laminated fabric for insoluble adhesives some manufacturers are introducing zinc-free adhesives. In addition to the active ingredients in denture adhesives, a number of non-active components may also be included -such as flavouring additives, colourings, preservatives and antimicrobial agents (7,14,15) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Autoclave on Bacterial Growth Isolated from Different Types of Denture Adhesives

Alloaibi¹

2017

Iraqi dent. j.

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Background: Different types of denture adhesives like powder or paste have been used to enhance the retention and stability in denture wearers, especially in patients with resorbed ridges , these adhesives should be free from microbial contamination in order to use safely inside patient mouth and avoid infection , the purpose of this study is to investigate the bacterial contamination of different adhesives pastes and powders and the effect of autoclaving in reducing the bacterial growth . Materials and Methods:Six types of commonly available denture adhesives (three powders and three pastes) were tested for bacterial contamination by using culture on suitable media that contained either brain-heart infusion (BHI) ,blood agar, nutrient agar,MSA agar and others were inoculated with 0.5 gm samples of each adhesive. plates were incubated at 37C˚ for 24 hours in pre and post sterilization by using the colony forming unit for estimation the bacterial growth. Results : The results revealed that , In pre sterilization test all adhesive types (powders and pastes ) contained Gram positive and Gram negative bacteria ,the results also revealed that Dentofix (paste type 1) has the lowest bacterial growth in which 40% without bacterial growth , also the results reported that 25% of adhesives were contaminated by Staphylococcus species and 23 % of adhesives were contaminated by Neisseria species .Dentofix paste was highly significant difference regarding the mean of bacterial count at both dilutions 1/10 and 1/100 among other adhesives with the lowest contamination in comparison to other types of denture adhesives in presterilization step.while after using sterilization by autoclave generally sterilization induce high significant difference in each type of denture adhesive after exposure to autoclave for 15 min at 121 °C 15 pound/inch it decreases the number of bacterial growth in all types. The results showed that powders adhesives had high contamination rate than pastes and their killing rate after sterilization was lower than pastes. Fittydent (paste type 3) was highly affected by sterilization than other adhesives in first dilution 1/10 when killing rate was 78.9% . all types of tested adhesives showing that in second dilution 1/100 sterilization more effective at this dilution and sterilization induce 100% killing in Dentofix ( paste type 1) , Bonyplus ( paste type 2) and Fittydent (paste type 3) . Conclusions: The result of this study concluded that the powders denture adhesive have high bacterial contamination rate than the pastes and using of sterilization by autoclave must be done to increase killing rate.

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Denture cream

Abstract: Denture cream contains zinc, and chronic excessive use may result in hypocupremia and serious neurologic disease.

Cited by 178 publications

References 31 publications

Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy

Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy

Zinc poisoning from excessive denture fixative use masquerading as myelopolyneuropathy and hypocupraemia

Effect of Autoclave on Bacterial Growth Isolated from Different Types of Denture Adhesives

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